ChemicalBook > CAS DataBase List > 2-Methanesulfonyl-4,6-dimethoxypyrimidine

2-Methanesulfonyl-4,6-dimethoxypyrimidine

Product Name: 2-Methanesulfonyl-4,6-dimethoxypyrimidine
CAS No.: 113583-35-0
Chemical Name: 2-Methanesulfonyl-4,6-dimethoxypyrimidine
Synonyms: MSDP;DMMSP;4,6-DIMETHOXY-2-(METHYLSULFONYL)PYRIMIDINE;4,6-DIMETHOXY-2-METHYL-SULFONYLPYRIMIDIME;21158;2-Methanesulfonyl-4;2-Methylsulfonyl-4,6;4,6-dimethoxy-2-mesyl-pyrimidine;4,6-DIMETHOXY-2-(METHYLSULFONYL);DiMethoxy-2-(Methylsulfonyl)pyriM
CBNumber: CB3117219
Molecular Formula: C7H10N2O4S
Formula Weight: 218.23
MOL File: 113583-35-0.mol

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2-Methanesulfonyl-4,6-dimethoxypyrimidine Property

Melting point:: 129-133 °C(lit.)
Boiling point:: 412.6±48.0 °C(Predicted)
Density: 1.317±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: -3.39±0.30(Predicted)
color: Whtie
InChI: InChI=1S/C7H10N2O4S/c1-12-5-4-6(13-2)9-7(8-5)14(3,10)11/h4H,1-3H3
InChIKey: ITDVJJVNAASTRS-UHFFFAOYSA-N
SMILES: C1(S(C)(=O)=O)=NC(OC)=CC(OC)=N1
CAS DataBase Reference: 113583-35-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 37/39-26-24/25
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 549878
Product name: 4,6-Dimethoxy-2-(methylsulfonyl)pyrimidine
Purity: 97%
Packaging: 25g
Price: $235
Updated: 2023/06/20

TCI Chemical

Product number: D3101
Product name: 4,6-Dimethoxy-2-(methylsulfonyl)pyrimidine
Purity: >98.0%(GC)
Packaging: 5g
Price: $68
Updated: 2025/07/31

TRC

Product number: D461475
Product name: 4,6-Dimethoxy-2-(methylsulfonyl)pyrimidine
Packaging: 100g
Price: $140
Updated: 2021/12/16

Matrix Scientific

Product number: 031266
Product name: 4,6-Dimethoxy-2-(methylsulfonyl)pyrimidine
Purity: 97%
Packaging: 25g
Price: $21
Updated: 2021/12/16

AK Scientific

Product number: A283
Product name: 2-Methanesulfonyl-4,6-dimethoxypyrimidine
Packaging: 25g
Price: $27
Updated: 2021/12/16

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2-Methanesulfonyl-4,6-dimethoxypyrimidine Chemical Properties,Usage,Production

Chemical Properties

White to off-white powder

Uses

4,6-Dimethoxy-2-(methylsulfonyl)pyrimidine may be used in the microwave assisted preparation of 4,6-dimethoxy-N-methylpyrimidin-2-amine by reacting with methylamine. It may also be used to prepare 2′-pyrimidinecarbonylsulfonanilide derivatives with potent herbicidal activity.

Uses

2-Methanesulfonyl-4,6-dimethoxypyrimidine was used to prepare nonpeptidic endothelin-A receptor antagonists.

Preparation

One method for preparing 2-Methanesulfonyl-4,6-dimethoxypyrimidine comprises with 4, 6-dihydroxyl-2-methylthiopyrimidine is a main raw material, and through superchlorination, methoxylation and oxidizing reaction, reaction formula is as follows:

General Description

4,6-Dimethoxy-2-(methylsulfonyl)pyrimidine can be prepared by the oxidation of 2-methylthio-4,6-dimethoxypyrimidine.

Synthesis

90905-46-7

113583-35-0

Example 10: Synthesis of 4,6-dimethoxy-2-(methylsulfonyl)pyrimidine To 200 mL of acetic acid was added 3% sodium tungstate as a catalyst. Subsequently, 1.0 mol of 2-methylsulfanyl-4,6-dimethoxypyrimidine was added to the solution and stirred until completely dissolved to form a clarified solution. The reaction mixture was heated to 40°C. Over a period of 4-8 hours, 2.1 mol of 30% H2O2 solution was slowly added to the heated reaction mixture and stirring was continued at 40 °C for 3-5 hours. After that, 0.05 mol of 30% H2O2 solution was added supplementally and stirring was continued at the same temperature until the reaction was complete (the progress of the reaction was monitored by TLC or HPLC). After completion of the reaction, the reaction mixture was cooled to room temperature and the precipitated solid was collected by filtration. The resulting solid was washed sequentially with aqueous acetic acid and deionized water to remove impurities. Finally, the washed solid was dried under appropriate conditions to obtain the target product in 83% yield. The filtrate portion was extracted with dichloroethane, and after separating the organic layer, the dichloroethane layer was concentrated to give a residue of about 42 g containing a small amount of product in about 1-1.5% yield.

References

[1] Asian Journal of Chemistry, 2014, vol. 26, # 1, p. 313 - 314
[2] Journal of Agricultural and Food Chemistry, 2018, vol. 66, # 15, p. 3773 - 3782
[3] Pesticide Science, 1996, vol. 47, # 2, p. 115 - 124
[4] Patent: WO2014/128719, 2014, A2. Location in patent: Page/Page column 17
[5] Journal of Labelled Compounds and Radiopharmaceuticals, 2006, vol. 49, # 4, p. 339 - 343

2-Methanesulfonyl-4,6-dimethoxypyrimidine Preparation Products And Raw materials

Raw materials

Pyramat Sodium Methoxide

Preparation Products

Bispyribac-sodium Pyribenzoxim

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View Lastest Price from 2-Methanesulfonyl-4,6-dimethoxypyrimidine manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 2-Methanesulfonyl-4,6-dimethoxypyrimidine 113583-35-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98
Supply Ability: 10000KGS
Release date: 2025-11-25

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 2-Methylsulfonyl-4,6-dimethoxypyrimidine 113583-35-0
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 99%min
Supply Ability: 1000kgs
Release date: 2021-11-16

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 2-Methylsulfonyl-4,6-dimethoxypyrimidine 113583-35-0
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 ton
Release date: 2024-11-12

113583-35-0, 2-Methanesulfonyl-4,6-dimethoxypyrimidineRelated Search:

2-Amino-4,6-dimethylpyrimidine 4,6-Dimethoxy-2-(phenoxycarbonyl)aminopyrimidine (Trifluoromethoxy)benzene m-Anisyl alcohol Methoxyacetic acid Anisole Dimethyldimethoxysilane p-Anisidine 2,6-Dihydroxybenzoic acid 2-Mercapto-4,6-dimethoxypyrimidine 4,6-Dimethoxypyrimidine SULFACHLOROPYRIDAZINE Methanesulfonic acid 4,6-DIMETHOXY-2-(METHYLSULFONYL)PYRIMIDINE 2-METHANESULFONYL-PYRIMIDINE 4,6-Dimethoxy-2-methylthiopyrimidine 4,6-Dimethylpyrimidine-2-sulfonamide 2-Methylthio-4,6-pyrimidinedione

DMMSP

4,6-DIMETHOXY-2-(METHYLSULFONYL)PYRIMIDINE

4,6-DIMETHOXY-2-METHYL-SULFONYLPYRIMIDIME

2-METHYLSULFONYL-4,6-DIMETHOXYPYRIMIDINE

2-METHYLSULFONY-4,6-DIMETHOXYPYRIDINE

2-METHANESULFONYL-4,6-DIMETHOXY-PYRIMIDINE

PYRIMIDINE, 4,6-DIMETHOXY-2-(METHYLSULFONYL)-

2-Methylsulfony-4,5-Dimethoxypyridine

4,6-DIMETHYL-2-(METHOXYSULFONYL)PYRIMIDINE , 97%

4,6-dimethoxy-2-mesyl-pyrimidine

2-methylsulfony-4,6-dimethoxypyrimidine

DIMETHOXY-2-METHANESULFONYLPYRIMIDINE

4,6-DIMETHOXY-2-(METHYLSULFONYL)PYRIMIDINE 98+%

4,6-Dimethoxy-2-(Methylsulphonyl)Pyrimidine

4,6-DIMETHOXY-2-(METHYLSULFONYL)

4,6-Dimethyloxide-2-methylsulfonylpyrimidine

2-methylsulphonyl-4,6-dimethoxypyrimidine

4,5-dimethoxy-2-methylsulfonylpyrimidine

2-Methylsulfonyl-4,6-dimethoxypyrimidine,97%

2-Methylsulfonyl-4,6

4,6-Dimethoxy-2-(methylsulfonyl)pyrimidine,97%

2-Methanesulfonyl-4

2-Methylsulfonyl-4,6-dimethoxypyrimidine ,98%

4,6-Dimethoxy-2-(methylsulphonyl)-1,3-diazine, 4,6-Dimethoxypyrimidin-2-yl methyl sulphone

4,6- twoMethoxy -2-Methyl sulfonylpyriMidinyl

DiMethoxy-2-(Methylsulfonyl)pyriM

21158

4,6-Dimethoxy-2-(methylsulfonyl)pyrimidine&gt

MSDP

2-Methylsulfonyl-4,6-dimethoxypyrimidine ISO 9001：2015 REACH

2-Methylsulfonyl-4,6-dimethoxypyrimidin

113583-35-0

13583-35-0

C7H10N2O4S

D2933G1

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