magnolin

Product Name: magnolin
CAS No.: 31008-18-1
Chemical Name: magnolin
Synonyms: Maglin;Magnolin;magnolitin;Magnolin-RM;Medioresinol dimethyl ether;Benzene, bis(chloromethyl)dimethyl-;Magnolin, 98%, from Magnolia liliflora Desr.;1H,3H-Furo[3,4-c]furan, 1-(3,4-dimethoxyphenyl);tetrahydro-4-(3,4,5-trimethoxyphenyl)-,(1S,3aR,4S,6aR)-;(1S,3aR,4S,6aR)-1-(3,4-dimethoxyphenyl)-4-(3,4,5-trimethoxyp...
CBNumber: CB31335188
Molecular Formula: C23H28O7
Formula Weight: 416.46
MOL File: 31008-18-1.mol

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magnolin Property

Melting point:: 91.4-92.9 °C
Boiling point:: 536.9±50.0 °C(Predicted)
Density: 1.178±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
form: Solid
color: White to Off-White

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Safety

Safety Statements: 24/25
HS Code: 29329990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 25123
Product name: Magnolin
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 25123
Product name: Magnolin
Purity: ≥98%
Packaging: 5mg
Price: $139
Updated: 2024/03/01

Cayman Chemical

Product number: 25123
Product name: Magnolin
Purity: ≥98%
Packaging: 10mg
Price: $243
Updated: 2024/03/01

Cayman Chemical

Product number: 25123
Product name: Magnolin
Purity: ≥98%
Packaging: 25mg
Price: $533
Updated: 2024/03/01

TRC

Product number: M110395
Product name: Magnolin
Packaging: 250mg
Price: $505
Updated: 2021/12/16

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magnolin Chemical Properties,Usage,Production

Description

Magnolin, a major component of Magnolia flos (Shin-Yi), inhibits the Ras/ERKs/RSK2 signaling axis by targeting the active pocket of ERK1 and ERK2 with IC50s of 87 nM and 16.5 nM, respectively.

Uses

Magnolin is a lignan extract from Magnoliae Flos, displaying anti-asthma and anti-inflammatory activity.

in vitro

Magnolin is a natural compound abundantly found in Magnolia flos, which has been traditionally used in oriental medicine to treat headaches, nasal congestion and anti-inflammatory reactions. Magnolin targets the active pockets of ERK1 and ERK2, which are important signaling molecules in cancer cell metastasis. Magnolin inhibits NF-κB transactivation activity by suppressing the ERKs/RSK2 signaling pathway. Magnolin inhibits the production of tumor necrosis factor-α (TNF-α) and prostaglandin E2 (PGE2) by inhibiting extracellular signal-regulated kinases (ERKs), which are key signaling molecules in the regulation of cell proliferation, transformation and cancer cell metastasis. JB6 Cl41 cell migration enhanced by EGF treatment is dramatically suppressed by Magnolin treatment in a dose-dependent manner. Magnolin inhibits ERK1/2/RSK2 signaling-mediated IκBα phosphorylation at Ser32, resulting in the inhibition of NF-κB activation and cell migration.

magnolin Preparation Products And Raw materials

Raw materials

Preparation Products

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magnolin Suppliers

China 163 Germany 1 United Kingdom 2 United States 13 Global 179

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

ALB Technology Limited

Tel: 702-983-3769
Fax: 702-983-3769
Email: sales@albtechnology.com
Country: United States
ProdList: 2993
Advantage: 55

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32165
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

TargetMol Chemicals Inc.

Tel
Email: support@targetmol.com
Country: United States
ProdList: 38632
Advantage: 58

Wilshire Chemical Company Inc.

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Country: United States
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Alfa Chemistry

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Cayman Chemical Company

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ProdList: 6213
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United States Biological

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ProdList: 6214
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MedChemExpress

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Country: United States
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FortopChem Technology Limited

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Country: United States
ProdList: 1099
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View Lastest Price from magnolin manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: magnolin 31008-18-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2024-07-29

Shanghai Standard Technology Co., Ltd.

Product: Magnolin 31008-18-1
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-10-12

Shanghai Standard Technology Co., Ltd.

Product: Magnolin 31008-18-1
Price: US $0.00/mg
Min. Order: 5mg
Purity: Analytical Standard
Supply Ability: 10 g
Release date: 2019-10-12

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Magnolin

Maglin

Magnolin, 98%, from Magnolia liliflora Desr.

(1S,3aR,4S,6aR)-1-(3,4-dimethoxyphenyl)-4-(3,4,5-trimethoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan

1H,3H-Furo[3,4-c]furan, 1-(3,4-dimethoxyphenyl)tetrahydro-4-(3,4,5-trimethoxyphenyl)-, (1S,3aR,4S,6aR)-

(3S,3aR,6S,6aR)-3-(3,4-dimethoxyphenyl)-6-(3,4,5-trimethoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan

(1S,3aR,4S,6aR)-1-(3,4-dimethoxyphenyl)-4-(3,4,5-trimethoxyp...

magnolitin

Magnolin-RM

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31008-18-1

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