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Sodium chlorodifluoroacetate

Product Name
Sodium chlorodifluoroacetate
CAS No.
1895-39-2
Chemical Name
Sodium chlorodifluoroacetate
Synonyms
Sodium 2-chloro-2,2-difluoroacetate;2-chloro-2,2-difluoroacetate;SodiuM Difluorochloroacetate;CHLORODIFLUOROACETIC ACID SODIUM SALT;DIFLUOROCHLOROACETIC ACID SODIUM SALT;orodifL;Sodiumchlorodifluoride;Sodiumdifluorochlorate;Roflumilast impurity 24;SODIUM CHLORODIFLUOROACETATE
CBNumber
CB3135211
Molecular Formula
C2HClF2O2.Na
Formula Weight
153.47
MOL File
1895-39-2.mol
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Sodium chlorodifluoroacetate Property

Melting point:
196-198 °C (lit.)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Soluble in dimethoxyethane, diglyme (0.60 g mL-1), triglyme, dimethyl formamide.
form 
Powder
color 
White to off-white
BRN 
4162363
InChI
InChI=1S/C2HClF2O2.Na.H/c3-2(4,5)1(6)7;;/h(H,6,7);;
InChIKey
MRTAVLDNYYEJHK-UHFFFAOYSA-M
SMILES
C(F)(F)(Cl)C(=O)O.[NaH]
CAS DataBase Reference
1895-39-2(CAS DataBase Reference)
EPA Substance Registry System
Acetic acid, chlorodifluoro-, sodium salt (1895-39-2)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-37/39-24/25-36/37/39
WGK Germany 
3
Hazard Note 
Irritant
TSCA 
T
HazardClass 
IRRITANT, HYGROSCOPIC
HS Code 
29159080
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
374067
Product name
Sodium chlorodifluoroacetate
Purity
96%
Packaging
25g
Price
$90.8
Updated
2025/07/31
TCI Chemical
Product number
C0991
Product name
Sodium Chlorodifluoroacetate
Purity
>99.0%(T)
Packaging
25g
Price
$29
Updated
2025/07/31
TCI Chemical
Product number
C0991
Product name
Sodium Chlorodifluoroacetate
Purity
>99.0%(T)
Packaging
100g
Price
$82
Updated
2025/07/31
TCI Chemical
Product number
C0991
Product name
Sodium Chlorodifluoroacetate
Purity
>99.0%(T)
Packaging
500g
Price
$267
Updated
2025/07/31
Usbiological
Product number
289074
Product name
Sodium chlorodifluoroacetate
Packaging
50g
Price
$333
Updated
2021/12/16
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Sodium chlorodifluoroacetate Chemical Properties,Usage,Production

Chemical Properties

white to off-white powder

Uses

It is used as pharmaceutical intermediate. Reactions of aldehydes with triphenylphosphine and sodium chlorodifluoroacetate yield 1,1-difluoro olefins. It is a general reaction and a one step synthesis.

Application

Sodium chlorodifluoroacetate is used for generation of difluorocarbene and the synthesis of difluorocyclopropanes and difluoroalkenes.

Preparation

Sodium chlorodifluoroacetate is prepared by careful neutralization of 130.5 g (1.0 mol) of chlorodifluoroacetic acid in 300 mL of Et2O with 53 g (0.5 mol) of anhydrous Na2CO3. The Et2O and water are removed under reduced pressure. The salt is then dried in a vacuum desiccator over P2O5. [1]

storage

Sodium chlorodifluoroacetate is an irritant and is hygroscopic.

References

1. Herkes, F. E.; Burton, D. J. OSC 1973, 5, 949

Sodium chlorodifluoroacetate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Sodium chlorodifluoroacetate manufacturers

Hangzhou Verychem Science And Technology Co.Ltd
Product
Sodium chlorodifluoroacetate 1895-39-2
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%min
Supply Ability
100 tons
Release date
2025-12-01
Hebei Chuanghai Biotechnology Co., Ltd
Product
Sodium chlorodifluoroacetate 1895-39-2
Price
US $9.90/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-26
Henan Aochuang Chemical Co.,Ltd.
Product
Sodium chlorodifluoroacetate 1895-39-2
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-09

1895-39-2, Sodium chlorodifluoroacetateRelated Search:

Dichloroacetyl chloride Sodium bicarbonate Sodium chlorite Sodium fluorosilicate Trisodium hexafluoroaluminate Sodium chloroacetate Sodium chloride Sodium hydroxide Sodium citrate Sodium benzoate Diclofenac sodium Sodium acetate Chlorodifluoroacetic acid Trisodium phosphate Difluoroacetic acid 8-CHLOROADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT Ethyl bromodifluoroacetate METHYL DIFLUOROACETATE

  • DIFLUOROCHLOROACETIC ACID SODIUM SALT
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  • Chlorodifluoroacetic acid sodiuM salt, 96% 25GR
  • 2-Chloro-2,2-difluoro-acetic Acid SodiuM Salt
  • SodiuM Difluorochloroacetate
  • Sodium 2-chloro-2,2-difluoroethanoate, Chloro(difluoro)acetic acid, sodium salt
  • Two fluorinesodiuM chloroacetate
  • Acetic acid,2-chloro-2,2-difluoro-, sodiuM salt (1:1)
  • orodifL
  • Roflumilast impurity 24
  • Sodium Chlorodifluoroacetate &gt
  • 2-chloro-2,2-difluoroacetate
  • Sodiumchlorodifluoride
  • Sodiumdifluorochlorate
  • 1895-39-2
  • 1985-39-2
  • C2ClFNaO2
  • ClCF2CO2Na
  • C2ClF2NaO2
  • C2ClF2O2Na
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