LACTAMIDE Property

Melting point:

73-76 °C(lit.)

Boiling point:

165.17°C (rough estimate)

Density 

1.1948 (rough estimate)

refractive index 

1.4368 (estimate)

pka

13.34±0.20(Predicted)

form 

powder to crystal

color 

White to Almost white

Water Solubility 

782.20g/L(25 ºC)

LogP

-1.161 (est)

CAS DataBase Reference

2043-43-8(CAS DataBase Reference)

Safety

Safety Statements 

22-24/25

WGK Germany 

3

HS Code 

2924.19.8000

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

LACTAMIDE Chemical Properties,Usage,Production

Uses

Lactamide is used as a synthetic raw material in organic chemistry, as an additive in cosmetics, and as a preservative in frozen semen and fertilized eggs in livestock reproduction studies.

Definition

ChEBI:Lactamide is a monocarboxylic acid amide that is lactic acid in which the carboxylic acid group has been converted to the corresponding carboxamide. It is a monocarboxylic acid amide and a secondary alcohol. It is functionally related to a rac-lactic acid.

Synthesis

α-Hydroxy methyl ester (10 mmol, 1.0 equiv) was added into the 100 ml RBF, anda saturated methanol solution of ammonia (20 ml, 38 equiv) was added underthe ice-water bath and stirred overnight. The mixture was concentrated underreduced pressure and in most case Lactamide were obtained in high yields,while in rare occasions purified by flash chromatography.