ChemicalBook > CAS DataBase List > 2-Amino-4-hydroxy-1H-pteridine

2-Amino-4-hydroxy-1H-pteridine

Product Name: 2-Amino-4-hydroxy-1H-pteridine
CAS No.: 2236-60-4
Chemical Name: 2-Amino-4-hydroxy-1H-pteridine
Synonyms: PTERIN;PTERINE;4-oxopterin;pteridoxamine;Pterine, ≥98%;Pterin【keto form】;2-Amino-4-oxodihyd;2-AMINO-4-PTERIDINOL;2-Aminopteridin-4-ol;Folic Acid Impurity 34
CBNumber: CB3140406
Molecular Formula: C6H5N5O
Formula Weight: 163.14
MOL File: 2236-60-4.mol

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2-Amino-4-hydroxy-1H-pteridine Property

Melting point:: 300 °C
Boiling point:: 290.2°C (rough estimate)
Density: 1.4240 (rough estimate)
refractive index: 1.9000 (estimate)
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: Acetonitrile: Soluble
Water: Soluble
form: powder
pka: 2.27(at 20℃)
biological source: synthetic
Water Solubility: 17.54mg/L(22.5 ºC)
BRN: 150294
InChI: InChI=1S/C6H5N5O/c7-6-10-4-3(5(12)11-6)8-1-2-9-4/h1-2H,(H3,7,9,10,11,12)
InChIKey: HNXQXTQTPAJEJL-UHFFFAOYSA-N
SMILES: N1C2C(=NC=CN=2)C(=O)NC=1N
CAS DataBase Reference: 2236-60-4(CAS DataBase Reference)
NIST Chemistry Reference: 4(1H)-pteridinone, 2-amino-(2236-60-4)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39
WGK Germany: 3
RTECS: UO3505000
F: 10-23
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P1132
Product name: Pterine
Purity: ~95%
Packaging: 50mg
Price: $98.1
Updated: 2025/07/31

Sigma-Aldrich

Product number: P1132
Product name: Pterine
Purity: ~95%
Packaging: 1g
Price: $502
Updated: 2025/07/31

Sigma-Aldrich

Product number: P1132
Product name: Pterine
Purity: ~95%
Packaging: 250mg
Price: $167
Updated: 2025/07/31

TRC

Product number: P839870
Product name: Pterin
Packaging: 1g
Price: $185
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA12181
Product name: 2-Amino-4-hydroxypteridine
Packaging: 100mg
Price: $42
Updated: 2021/12/16

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2-Amino-4-hydroxy-1H-pteridine Chemical Properties,Usage,Production

Chemical Properties

YELLOW-BEIGE CRYSTALLINE POWDER

Uses

Pterin is used in the biosynthesis and metabolism of tetrahydrobiopterin and molybdopterin.

Definition

ChEBI: 2-aminopteridin-4-ol is a 2-amino-4-hydroxypteridine. It is a tautomer of a 2-aminopteridin-4(3H)-one and a 2-aminopteridin-4(1H)-one.

Biological Activity

Pterine consists of pyrazine and pyrimidine with substitutions in keto and amino group. Pterine is present in all organisms including cyanobacteria. It acts as a cofactor for redox enzymes and serves as a precursor for folic acid synthesis. Pterine from the butterfly wings absorb light and elicit incoherent scattering. Pterine induces alterations in DNA by hydroxylation of deoxyguanosine.

Purification Methods

It is dissolved in hot 1% aqueous ammonia, filtered, and an equal volume of hot 1M aqueous formic acid is added. The solution is allowed to cool at 0-2o overnight. The solid is collected and washed with distilled water several times by centrifugation and dried in vacuo over P2O5 overnight, and then at 100o overnight (any ammonium formate in the sample evaporates off). [Beilstein 26 III/IV 3936.]

References

[1] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[2] RAMASAMY MAHENDRAN. Evaluation of Pterin, a Promising Drug Candidate from Cyanide Degrading Bacteria.[J]. Current Microbiology, 2018, 75 6: 684-693. DOI: 10.1007/s00284-018-1433-0
[3] SANJEEWA GAMAGEDARA Yinfa M Stephen Gibbons. Investigation of urinary pteridine levels as potential biomarkers for noninvasive diagnosis of cancer[J]. Clinica Chimica Acta, 2011, 412 1: Pages 120-128. DOI: 10.1016/j.cca.2010.09.015

2-Amino-4-hydroxy-1H-pteridine Preparation Products And Raw materials

Raw materials

Glyoxal 2,5,6-Triaminopyrimidin-4-ol sulphate

Preparation Products

(6R,S)-5,6,7,8-TETRAHYDRO-L-BIOPTERIN DIHYDROCHLORIDE

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2236-60-4, 2-Amino-4-hydroxy-1H-pteridineRelated Search:

Acetaminophen CHLOROPHOSPHONAZO III Protocatechuic acid EC 2.6.1.2 2-Chloro-3-hydroxypyridine 3-Aminophenol ALTRENOGEST Glycine Triamterene 6-Aminocaproic acid 10-Formylfolic Acid Tris(hydroxymethyl)aminomethane 2-Amino-4-hydroxypteridine-6-methanol 2-Amino-7-(chloromethyl)pteridin-4(1H)-one Levomefolate calcium N-(p-Aminobenzoyl)glutamic acid Folic Acid Impurity C (2S)-2-[[4-[Bis[(2-aMino-4-oxo-1,4-dihydropteridin-6-yl)Methyl]aMino]benzoyl]aMino]pentanedioic Acid

2-AMino-1,5-dihydropteridin-4-ol

2-AMINO-4-OXODIHYDROPTERIDINE

2-AMINO-4-PTERIDINOL

2-AMINO-4-HYDROXYPTERIDINE

2-AMINO-4-HYDROXY-1H-PTERIDINE

PTERIN

PTERINE

2-amino-1H-pteridin-4-one

2-Amino-4-oxy-3,4-dihydropteridine

2-amino-4-hydroxyaminopteridine

4(1H)-Pteridinone,2-amino-

2-amino-4(1h)-pteridinon

2-amino-4(1h)-pteridinone

4-oxopterin

pteridoxamine

2-AMINO-4-HYDROXYPTERIDINE 98%

2-Amino-4-hydroxypteridine, 2-Amino-4-oxodihydropteridine

2-Aminopteridin-4(1H)-one

2-Aminopteridin-4-ol

Pterin【keto form】

2-Amino-4-hydroxy-1H-pteridine,97%

2-Amino-4-hydroxy-1H-pteridinePterin

2-Amino-4-hydroxypteridine ,97%

2-Amino-4-oxodihyd

2-Aminopteridin-4(3H)-one

2-Amino-3H-pteridin-4-one

Sapropterin Dihydrochloride Impurity D

4(3H)-Pteridinone, 2-amino-

Folic Acid Impurity 34

Pterine, ≥98%

2-aminopteridin-4(8H)-one

Sepiapterin Impurity 9

2236-60-4

C6H5N5O

Biochemicals and Reagents

BioChemical

Enzyme Inhibitors by Type

Enzymes, Inhibitors, and Substrates

Enzyme Inhibitors

Cofactors

Substrate Analogs

Oxidation-Reduction

Heterocycles