4-chloro-6,7-dimethoxy-2-methylquinazoline

Product Name: 4-chloro-6,7-dimethoxy-2-methylquinazoline
CAS No.: 50377-49-6
Chemical Name: 4-chloro-6,7-dimethoxy-2-methylquinazoline
Synonyms: 2-Methyl-4-chloro-6,7-dimethoxyquinoline;4-chloro-6,7-dimethoxy-2-methylquinazoline;4-Chloro-2-methyl-6,7-dimethoxyquinazoline;Quinazoline, 4-chloro-6,7-dimethoxy-2-methyl-
CBNumber: CB31465085
Molecular Formula: C11H11ClN2O2
Formula Weight: 238.67
MOL File: 50377-49-6.mol

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4-chloro-6,7-dimethoxy-2-methylquinazoline Property

Boiling point:: 287℃
Density: 1.281
Flash point:: 127℃
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
Appearance: Light yellow to brown Solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

AK Scientific

Product number: 6918AB
Product name: 4-Chloro-6,7-dimethoxy-2-methylquinazoline
Packaging: 250mg
Price: $196
Updated: 2021/12/16

AK Scientific

Product number: 6918AB
Product name: 4-Chloro-6,7-dimethoxy-2-methylquinazoline
Packaging: 1g
Price: $415
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0050043
Product name: 4-CHLORO-6,7-DIMETHOXY-2-METHYLQUINAZOLINE
Purity: 95.00%
Packaging: 1G
Price: $794.36
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0050043
Product name: 4-CHLORO-6,7-DIMETHOXY-2-METHYLQUINAZOLINE
Purity: 95.00%
Packaging: 5G
Price: $1388.6
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0050043
Product name: 4-CHLORO-6,7-DIMETHOXY-2-METHYLQUINAZOLINE
Purity: 95.00%
Packaging: 10G
Price: $2055.62
Updated: 2021/12/16

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4-chloro-6,7-dimethoxy-2-methylquinazoline Chemical Properties,Usage,Production

Synthesis

35241-23-7

50377-49-6

Step b Synthesis of 4-chloro-6,7-dimethoxy-2-methylquinazoline: 6,7-dimethoxy-2-methylquinazolin-4(3H)-one (1.0 g) was mixed with phosphorus trichloride (20 mL) and heated to reflux for 3 hours. After the reaction was completed, the mixture was cooled to room temperature, slowly poured into ice water and stirred for 10 min. The aqueous phase was extracted with chloroform (3 x 100 mL), the organic phases were combined, washed sequentially with water and saturated saline, and dried over anhydrous sodium sulfate. The desiccant was removed by filtration and the filtrate was concentrated under reduced pressure to give the yellow solid product 4-chloro-6,7-dimethoxy-2-methylquinazoline (1.0 g, 92% yield) with a melting point of 182-184 °C. 1H NMR (400 MHz, CDCl3): δ 7.36 (1H, s), 7.30 (1H, s), 4.06 (6H, s), 2.81 (3H, s); LC-MS (positive ion mode): m/z 239, 241 [M+H]+.

References

[1] Patent: US2013/266563, 2013, A1. Location in patent: Paragraph 0327
[2] Synthesis, 2004, # 3, p. 429 - 435
[3] Journal of Medicinal Chemistry, 1996, vol. 39, # 1, p. 267 - 276
[4] ChemMedChem, 2014, vol. 9, # 7, p. 1476 - 1487

4-chloro-6,7-dimethoxy-2-methylquinazoline Preparation Products And Raw materials

Raw materials

Preparation Products

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4-chloro-6,7-dimethoxy-2-methylquinazoline Suppliers

China 47 Germany 1 India 1 United States 10 Global 59

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50377-49-6, 4-chloro-6,7-dimethoxy-2-methylquinazolineRelated Search:

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4-chloro-6,7-dimethoxy-2-methylquinazoline

2-Methyl-4-chloro-6,7-dimethoxyquinoline

4-Chloro-2-methyl-6,7-dimethoxyquinazoline

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50377-49-6