ChemicalBook > CAS DataBase List > 2-Chloro-3-methoxyaniline
2-Chloro-3-methoxyaniline
- Product Name
- 2-Chloro-3-methoxyaniline
- CAS No.
- 113206-03-4
- Chemical Name
- 2-Chloro-3-methoxyaniline
- Synonyms
- 2-chloro-3-Methoxy-;2-Chloro-3-methoxyaniline;2-chloro-3-methoxyl-aniline;2-Chloro-3-methoxybenzenamine;(2-Chloro-3-methoxyphenyl)amine;Benzenamine, 2-chloro-3-methoxy-;3-AMino-2-chloroanisole[2-Chloro-3-Methoxyaniline];1,3-ADAMANTANEDIMETHANOL,ALPHA,ALPHA,ALPHA'',ALPHA';1,3-ADAMANTANEDIMETHANOL,ALPHA,ALPHA,ALPHA'',ALPHA''-TETRAMETHYL-(6CI)
- CBNumber
- CB31465656
- Molecular Formula
- C7H8ClNO
- Formula Weight
- 157.6
- MOL File
- 113206-03-4.mol
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2-Chloro-3-methoxyaniline Property
- Melting point:
- 50 °C
- Boiling point:
- 125 °C(Press: 3 Torr)
- Density
- 1.234±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 2.23±0.10(Predicted)
- Appearance
- Gray to brown Solid
- InChI
- InChI=1S/C7H8ClNO/c1-10-6-4-2-3-5(9)7(6)8/h2-4H,9H2,1H3
- InChIKey
- ZWPVZYDSURGWSY-UHFFFAOYSA-N
- SMILES
- C1(N)=CC=CC(OC)=C1Cl
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TRC
- Product number
- C380690
- Product name
- 2-Chloro-3-methoxyaniline
- Packaging
- 1g
- Price
- $85
- Updated
- 2021/12/16
TRC
- Product number
- C380690
- Product name
- 2-Chloro-3-methoxyaniline
- Packaging
- 10g
- Price
- $320
- Updated
- 2021/12/16
TRC
- Product number
- C380690
- Product name
- 2-Chloro-3-methoxyaniline
- Packaging
- 25g
- Price
- $745
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 072566
- Product name
- 2-Chloro-3-methoxyaniline
- Purity
- 95+%
- Packaging
- 1g
- Price
- $51
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FC07940
- Product name
- 2-Chloro-3-methoxyaniline
- Packaging
- 2g
- Price
- $65.65
- Updated
- 2021/12/16
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2-Chloro-3-methoxyaniline Chemical Properties,Usage,Production
Uses
2-Chloro-3-methoxyaniline is a reactant used in the preparation of dual inhibitors of CK2 and Pim kinases with antiproliferative activity against cancer cells.
Synthesis
3970-39-6
113206-03-4
General procedure for the synthesis of 2-chloro-3-methoxyaniline from 2-chloro-3-nitroanisole: 2-chloro-3-nitroanisole (1.38 g, 7.36 mmol) was dissolved in a solvent mixture of glacial acetic acid (19 mL) and acetonitrile (19 mL). To this solution was added iron powder (1.64 g, 29.4 mmol). The reaction mixture was stirred under reflux conditions for 3.5 hours. After completion of the reaction, the mixture was diluted with water (70 mL) and neutralized with solid sodium carbonate (Na2CO3). Subsequently, the product was extracted with dichloromethane (3 x 150 mL). The organic phases were combined, washed with saturated saline, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to afford the crude product 2-chloro-3-methoxyaniline (1.2 g, 100% yield) as a yellow oil. The product was used directly in the next reaction without further purification. Mass spectrometry (MS) analysis showed a molecular ion peak of 157.9 (MH)+; high performance liquid chromatography (HPLC, with TFA as additive) showed a purity of 86% at 220 nm.
References
[1] Patent: WO2004/103996, 2004, A1. Location in patent: Page 42-43
[2] Patent: WO2006/7700, 2006, A1. Location in patent: Page/Page column 62
[3] Patent: US2006/19905, 2006, A1. Location in patent: Page/Page column 25
[4] Patent: WO2006/85, 2006, A1. Location in patent: Page/Page column 77-78
[5] Chemistry - A European Journal, 2017, vol. 23, # 42, p. 9996 - 10000
2-Chloro-3-methoxyaniline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Chloro-3-methoxyaniline manufacturers
Career Henan Chemical Co
- Product
- 2-Chloro-3-methoxyaniline 113206-03-4
- Price
- US $9.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg -1000kg
- Release date
- 2020-01-03
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