Clinafloxacin hydrochloride
- Product Name
- Clinafloxacin hydrochloride
- CAS No.
- 105956-99-8
- Chemical Name
- Clinafloxacin hydrochloride
- Synonyms
- M 1091;KR 11095;ClinafoxacinHCl;CLINAFLOXACIN HCL;Clinafloxacinhydrochloride;CLINANFLOXACIN HYDROCHLORIDE;HYDROGEN CLINAFLOXACIN CHLORIDE;Clinafloxacin hydrochloride USP/EP/BP;Clinafloxacin hydrochloride (PD127391);7-(3-aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-carboxylic acid hydrochloride
- CBNumber
- CB3148235
- Molecular Formula
- C17H18Cl2FN3O3
- Formula Weight
- 402.25
- MOL File
- 105956-99-8.mol
Clinafloxacin hydrochloride Property
- Melting point:
- 162-168°C
- storage temp.
- Refrigerator
- solubility
- DMSO (Slightly), Methanol (Slightly), Water (Slightly, Heated)
- form
- Solid
- color
- Pale Yellow to Light Yellow
- Stability:
- Hygroscopic
N-Bromosuccinimide Price
- Product number
- 16923
- Product name
- Clinafloxacin (hydrochloride)
- Purity
- ≥95%
- Packaging
- 100mg
- Price
- $93
- Updated
- 2024/03/01
- Product number
- 16923
- Product name
- Clinafloxacin (hydrochloride)
- Purity
- ≥95%
- Packaging
- 1g
- Price
- $456
- Updated
- 2024/03/01
- Product number
- 16923
- Product name
- Clinafloxacin (hydrochloride)
- Purity
- ≥95%
- Packaging
- 250mg
- Price
- $184
- Updated
- 2024/03/01
- Product number
- 16923
- Product name
- Clinafloxacin (hydrochloride)
- Purity
- ≥95%
- Packaging
- 500mg
- Price
- $292
- Updated
- 2024/03/01
- Product number
- C579000
- Product name
- ClinafloxacinHydrochloride
- Packaging
- 500mg
- Price
- $340
- Updated
- 2021/12/16
Clinafloxacin hydrochloride Chemical Properties,Usage,Production
Chemical Properties
Pale Yellow Solid
Uses
antibacterial
Uses
A new fluoroquinolone antimicrobial agent as a potent intraphagocytic bactericidal agent for both gram-positive and gram-negative bacteria.
Biological Activity
clinafloxacin is a broad-spectrum antibiotic of the quinolone carboxylic acid category that inhibits both dna gyrase and topoisomerase iv dually in streptococcus pneumonia. clinafloxacin, a fluoroquinolone, is currently in development for oral and intravenous therapy of serious infections.in selected volunteer subjects and patients, after the administration of oral and intravenous doses of racemic drug, the clinafloxacin showed a broad-spectrum antibiotic of the quinolone carboxylic acid category. the absorption of the clinafloxacin enantiomer was rapid after oral 400 mg dose and 400 mg intravenous dose of racemic drug [1]. clinafloxacin showed high activity against s. pneumoniae 7785 with the mic value of 0.125 μg/ml. clinafloxacin showed potent broad-spectrum in vitro activity against gram-positive, gram-negative, and anaerobic pathogens [2]. clinafloxacin has been identified as the most active fluoroquinolone against s. pneumoniae compared to grepafloxacin, levofloxacin, ofloxacin, sparfloxacin, and trovafloxacin and is currently being evaluated as an antipneumococcal agent [3].
References
[1]. humphrey g h, shapiro m a, randinitis e j, et al. pharmacokinetics of clinafloxacin enantiomers in humans[j]. the journal of clinical pharmacology, 1999, 39(11): 1143-1150.
[2]. pan x s, fisher l m. dna gyrase and topoisomerase iv are dual targets of clinafloxacin action in streptococcus pneumoniae[j]. antimicrobial agents and chemotherapy, 1998, 42(11): 2810-2816.
[3]. jorgensen j h, weigel l m, swenson j m, et al. activities of clinafloxacin, gatifloxacin, gemifloxacin, and trovafloxacin against recent clinical isolates of levofloxacin-resistant streptococcus pneumoniae[j]. antimicrobial agents and chemotherapy, 2000, 44(11): 2962-2968.
Clinafloxacin hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Clinafloxacin hydrochloride Suppliers
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View Lastest Price from Clinafloxacin hydrochloride manufacturers
- Product
- Clinafloxacin hydrochloride 105956-99-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-07-19
- Product
- Clinafloxacin hydrochloride 105956-99-8
- Price
- US $1.00/KG
- Min. Order
- 1G
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-08-20