1-BOC-4-(CYANOACETYL)PIPERIDINE

Product Name: 1-BOC-4-(CYANOACETYL)PIPERIDINE
CAS No.: 660406-84-8
Chemical Name: 1-BOC-4-(CYANOACETYL)PIPERIDINE
Synonyms: 1-BOC-4-(CYANOACETYL)PIPERIDINE;1-Boc-4-(2-cyanoacetyl)piperidine;4-(Cyanoacetyl)piperidine, N-BOC protected;4-(Cyanoacetyl)piperidine, N-BOC protected 97%;tert-Butyl 4-(2-cyanoacetyl)piperidine-1-carboxylate;4-(2-Cyanoacetyl)piperidine-1-carboxylic acid tert-butyl ester;1-Piperidinecarboxylic acid, 4-(cyanoacetyl)-, 1,1-diMethylethyl ester;1-Piperidinecarboxylic acid, 4-(2-cyanoacetyl)-, 1,1-dimethylethyl ester;tert-Butyl 4-(cyanoacetyl)piperidine-1-carboxylate, 1-(tert-Butoxycarbonyl)-4-(cyanoacetyl)piperidine, 3-[1-(tert-Butoxycarbonyl)piperidin-4-yl]-3-oxopropanenitrile
CBNumber: CB31556503
Molecular Formula: C13H20N2O3
Formula Weight: 252.31
MOL File: 660406-84-8.mol

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1-BOC-4-(CYANOACETYL)PIPERIDINE Property

Boiling point:: 365.0±32.0 °C(Predicted)
Density: 1.117±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: 9.36±0.20(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C13H20N2O3/c1-13(2,3)18-12(17)15-8-5-10(6-9-15)11(16)4-7-14/h10H,4-6,8-9H2,1-3H3
InChIKey: VSLLBQBSHAGKLC-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCC(C(CC#N)=O)CC1

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Safety

HS Code: 2924190090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B809680
Product name: tert-Butyl4-(2-Cyanoacetyl)piperidine-1-carboxylate
Packaging: 500mg
Price: $200
Updated: 2021/12/16

TRC

Product number: B809680
Product name: tert-Butyl4-(2-Cyanoacetyl)piperidine-1-carboxylate
Packaging: 1g
Price: $310
Updated: 2021/12/16

Activate Scientific

Product number: AS13143
Product name: 1-Boc-4-(cyanoacetyl)piperidine
Purity: 95+%
Packaging: 5G
Price: $371
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H48-1-P7
Product name: 4-(Cyanoacetyl)piperidine, N-Boc protected
Packaging: 5G
Price: $484
Updated: 2021/12/16

AK Scientific

Product number: Y9759
Product name: tert-Butyl4-(2-cyanoacetyl)piperidine-1-carboxylate
Packaging: 5g
Price: $262
Updated: 2021/12/16

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1-BOC-4-(CYANOACETYL)PIPERIDINE Chemical Properties,Usage,Production

Synthesis

124443-68-1

75-05-8

660406-84-8

GENERAL STEPS: Potassium tert-butoxide (69 g, 616 mmol) was added batchwise to a mixed solution of tetrahydrofuran (1 L) and acetonitrile (53 mL, 1027 mmol) of methyl 1-tert-butyloxycarbonyl-4-piperidinecarboxylate (50 g, 206 mmol) under ice-bath cooling conditions. The reaction mixture was gradually warmed to room temperature and stirred for 1 hour. Subsequently, the reaction mixture was slowly poured into saturated aqueous ammonium chloride solution (2 L) to terminate the reaction. The aqueous phase was extracted with ethyl acetate (3 x 500 mL) and the organic phase was combined. The organic phase was washed with saturated aqueous sodium chloride solution, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the light yellow oily product tert-butyl 4-(2-cyanoacetyl)piperidine-1-carboxylate (40 g, 77% yield). The product was detected by thin layer chromatography (TLC) with the unfolding agent ratio of petroleum ether/ethyl acetate=2:1 and Rf value of 0.5.

References

[1] Patent: WO2014/111496, 2014, A1. Location in patent: Page/Page column 153
[2] Patent: EP3287463, 2018, A1. Location in patent: Paragraph 0225; 0226
[3] Journal of Medicinal Chemistry, 2015, vol. 58, # 20, p. 8182 - 8199
[4] Patent: WO2016/138532, 2016, A1. Location in patent: Paragraph 0251

1-BOC-4-(CYANOACETYL)PIPERIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-BOC-4-(CYANOACETYL)PIPERIDINE Suppliers

China 64 India 1 Switzerland 1 United Kingdom 1 United States 6 Global 73

Anhui Yongsheng Pharmaceutical Technology Co., Ltd

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Struchem Co., Ltd.

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View Lastest Price from 1-BOC-4-(CYANOACETYL)PIPERIDINE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 1-Boc-4-(cyanoacetyl)piperidine 660406-84-8
Price: US $1.10-9.90/KG
Min. Order: 1KG
Purity: 99% min
Supply Ability: 100kg
Release date: 2025-08-18

Career Henan Chemical Co

Product: 1-BOC-4-(CYANOACETYL)PIPERIDINE 660406-84-8
Price: US $6.60/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg -1000kg
Release date: 2020-01-02

660406-84-8, 1-BOC-4-(CYANOACETYL)PIPERIDINERelated Search:

1-BOC-4-(CYANOACETYL)PIPERIDINE 4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester tert-butyl 4-[(2E)-2-cyano-3-(dimethylamino)prop-2-enoyl]piperidine-1-carboxylate Benzeneacetic acid,4-nitro-, 1,1-dimethylethyl ester CARBAMIC ACID, (3-BROMO-2-PYRIDINYL)-, 1,1-DIMETHYLETHYL ESTER tert-butyl 6-broMonaphthalen-2-ylcarbaMate tert-Butyl 7-amino-1H-indole-1-carboxylate TERT-BUTYL 2-CYCLOHEXYLHYDRAZINECARBOXYLATE [1-(4-BROMO-PHENYL)-ETHYL]-CARBAMIC ACID TERT-BUTYL ESTER tert-Butyl 4-cyanobenzyl(methyl)carbamate TERT-BUTYL 4-CYANOBENZYLCARBAMATE Carbamic acid, (1,1-dimethyl-2-propynyl)-, 1,1-dimethylethyl ester (9CI) tert-butyl(3-hydroxyphenethyl)carbamate (3-BROMO-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER Carbamic acid, (2-hydroxy-2-methylpropyl)-, 1,1-dimethylethyl ester (9CI) tert-butyl 3-bromo-2-hydroxyphenylcarbamate tert-butyl 3-hydroxy-4-methylphenylcarbamate tert-butyl 4-(prop-2-ynyl)piperidine-1-carboxylate

1-BOC-4-(CYANOACETYL)PIPERIDINE

4-(Cyanoacetyl)piperidine, N-BOC protected

tert-Butyl 4-(cyanoacetyl)piperidine-1-carboxylate, 1-(tert-Butoxycarbonyl)-4-(cyanoacetyl)piperidine, 3-[1-(tert-Butoxycarbonyl)piperidin-4-yl]-3-oxopropanenitrile

tert-Butyl 4-(2-cyanoacetyl)piperidine-1-carboxylate

1-Piperidinecarboxylic acid, 4-(cyanoacetyl)-, 1,1-diMethylethyl ester

4-(2-Cyanoacetyl)piperidine-1-carboxylic acid tert-butyl ester

1-Boc-4-(2-cyanoacetyl)piperidine

4-(Cyanoacetyl)piperidine, N-BOC protected 97%

1-Piperidinecarboxylic acid, 4-(2-cyanoacetyl)-, 1,1-dimethylethyl ester

660406-84-8