BUCLIZINE, DIHYDROCHLORIDE

Product Name: BUCLIZINE, DIHYDROCHLORIDE
CAS No.: 129-74-8
Chemical Name: BUCLIZINE, DIHYDROCHLORIDE
Synonyms: POSDEL;BUCLINA;softran;aphilanr;buclodin;UCB-4445;VIBAZINE;LONGIFENE;BUCLIZINE 2HCL;1-(4-(tert-Butyl)
CBNumber: CB3156784
Molecular Formula: C28H35Cl3N2
Formula Weight: 505.95
MOL File: 129-74-8.mol

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BUCLIZINE, DIHYDROCHLORIDE Property

Melting point:: 230-240°C
storage temp.: Inert atmosphere,2-8°C
solubility: Chloroform (Slightly), DMSO (Slightly, Heated), Methanol (Slightly)
form: powder
color: white to beige
Stability:: Hygroscopic
CAS DataBase Reference: 129-74-8
EPA Substance Registry System: Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]-, dihydrochloride (129-74-8)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1591
Product name: Buclizine dihydrochloride
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $120
Updated: 2024/03/01

Cayman Chemical

Product number: 25641
Product name: Buclizine (hydrochloride)
Purity: ≥98%
Packaging: 50mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 25641
Product name: Buclizine (hydrochloride)
Purity: ≥98%
Packaging: 100mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 25641
Product name: Buclizine (hydrochloride)
Purity: ≥98%
Packaging: 500mg
Price: $199
Updated: 2024/03/01

Cayman Chemical

Product number: 25641
Product name: Buclizine (hydrochloride)
Purity: ≥98%
Packaging: 1g
Price: $335
Updated: 2024/03/01

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BUCLIZINE, DIHYDROCHLORIDE Chemical Properties,Usage,Production

Chemical Properties

BUCLIZINE, DIHYDROCHLORIDE is Off-White Powder

Originator

Longifine,UCB

Uses

BUCLIZINE, DIHYDROCHLORIDE used as an antiemetic

Definition

ChEBI: Buclizine dihydrochloride is a hydrochloride salt that is obtained by reaction of buclizine with 2 equivalents of hydrogen chloride. It has a role as a central nervous system depressant, a local anaesthetic, a histamine antagonist, a cholinergic antagonist and an antiemetic. It contains a buclizine(2+).

Manufacturing Process

1 mol 4-chlorobenzhydril chloride was heated in toluene to reflux with 1 mol ethyl ester of piperazine 1-carboxylic acid at about 150°C in a presence of an excess of triethyl amine. On cooling the triethyl amine hydrochloride was filtered off, a solvent was removed in vacuum and the residue [(4-chlorophenyl)- phenyl-methyl]piperazine carboxylic acid ethyl ester was boiled straight away with potassium hydroxide in ethanol for 48 hours. After removing ethanol in vacuum to dryness, the residue was dissolved in benzene and washed with water. The benzene solution was dried, benzene removed in vacuum. The residue was distilled to give 4-chlorobezhydryl-piperazine. It had given the desired 1-(p-tert-butylbenzyl)-4-(p-chloro-α-phenylbenzyl)- piperazine, buclizine, by a reaction with 4-tert-butylbenzyl chloride in the presence of any halogen hydrochloride acceptor (triethyl amine, sodium or potassium carbonate and so on). The obtained product had BP: 230°- 240°C/0.001 mm Hg.

brand name

Bucladin (Stuart).

Therapeutic Function

Antihistaminic, Antiallergic, Antinauseant, Tranquilizer, Appetite stimulant

General Description

Buclizine hydrochloride, l-(p-tertbutylbenzyl)-4-(p-chloro-α-phenylbenzyl)piperazinedihydrochloride (Bucladin-S), is a white to slightly yellowcrystalline powder that is insoluble in water. The highlylipid-soluble buclizine has CNS depressant, antiemetic, andantihistaminic properties. This drug has been discontinued inthe United States.

Safety Profile

Poison by intraperitoneal route. An experimental teratogen. When heated to decomposition it emits very toxic fumes of NOx, and HCl.

BUCLIZINE, DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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BUCLIZINE, DIHYDROCHLORIDE Suppliers

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View Lastest Price from BUCLIZINE, DIHYDROCHLORIDE manufacturers

Career Henan Chemical Co

Product: BUCLIZINE, DIHYDROCHLORIDE 129-74-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200kgs
Release date: 2020-01-28

129-74-8, BUCLIZINE, DIHYDROCHLORIDERelated Search:

BUCLIZINE, DIHYDROCHLORIDE 1-(4-Chlorobenzhydryl)piperazine 1-Benzylpiperazine BUCLIZINE CHLORCYCLIZINE 4-tert-Butylbenzylamine CHLORCYCLIZINE HYDROCHLORIDE Cyclizine 1-[(4-CHLOROPHENYL)PHENYLMETHYL]-PIPERAZINE DIHYDROCHLORIDE 1-(4-CHLOROBENZYL)PIPERAZINE 1-(4-METHYLBENZYL)PIPERAZINE 1-(4-ETHYL-BENZYL)-PIPERAZINE migraleve (4-CHLOROPHENYL)PHENYLMETHYLAMINE HYDROCHLORIDE Chlorcyclizine dihydrochloride N-(4-ISOPROPYLBENZYL)ETHANAMINE N-ISOPROPYLPIPERAZINE DIHYDROCHLORIDE 1-(4-TERT-BUTYLBENZYL)PIPERAZINE

1-(p-tert-butylbenzyl)-4-(p-chloro-alpha-phenylbenzyl)-piperazindihydrochl

1-(p-tert-butylbenzyl)-4-(p-chlorodiphenylmethyl)piperazinedihydrochloride

1-(p-tert-butylbenzyl-4-p-chloro-alpha-phenylbenzyl)piperazinedihydrochlorid

1-p-chlorobenzhydryl-4-p-(t)-butylbenzylpiperazinedihydrochloride

aphilanr

buclizinehydrochloride

buclodin

1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)meth

LONGIFENE

1-(p-chlorobenzhydryl)-4-(p-t-butylbenzyl)diethylenediaminedihydrochloride

BUCLINA

BUCLIZINE, DIHYDROCHLORIDE

1-(4-(tert-Butyl)

-4-((4-chlorophenyl)

UCB-4445

VIBAZINE

POSDEL

BUCLIZINE 2HCL

Histabutizine dihydrochloride

UCB-4445, Buclina, Longifene, Posdel, Vibazine

piperazine,1-[(4-chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]me

softran

1-[(4-Chlorophenyl)phenylmethyl]-4-[[4-(tert-butyl)phenyl]methyl]piperazine dihydrochloride

1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)Methyl)piperazine dihydrochloride

Buclizine Hydrochloride(BP/EP)

Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]-, hydrochloride (1:2)

histabutyzinedihydrochloride

Buclizine USP/EP/BP

BUCLIZINE, DIHYDROCHLORIDE USP/EP/BP

Chlorphenazine hydrochloride

Buclizine HCl (UCB-4445)

Buclizine D8 DihydrochlorideQ: What is Buclizine D8 Dihydrochloride Q: What is the CAS Number of Buclizine D8 Dihydrochloride Q: What is the storage condition of Buclizine D8 Dihydrochloride

teratogen,Inhibitor,MCF-7,anti-tumor activity,antiallergic,antihistamine,inhibit,Histamine Receptor,Buclizine,Buclizine dihydrochloride

1-(4-(tert-butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine hydrochloride

129-74-8

C28H35Cl3N2

C28H33ClN22HCl

C28H37Cl3N2

C28H33ClN22ClH

Intermediates & Fine Chemicals

Pharmaceuticals

Inhibitors