ChemicalBook > CAS DataBase List > 2-Hydroxy-4-methyl-5-nitropyridine

2-Hydroxy-4-methyl-5-nitropyridine

Product Name
2-Hydroxy-4-methyl-5-nitropyridine
CAS No.
21901-41-7
Chemical Name
2-Hydroxy-4-methyl-5-nitropyridine
Synonyms
2-HYDROXY-5-NI;5-NITRO-4-PICOLIN-2-OL;4-METHYL-5-NITRO-2-PYRIDONE;4-METHYL-5-NITRO-2-PYRIDINOL;2-HYDROXY-5-NITRO-4-PICOLINE;4-Methyl-5-nitro-2-pyridinone;2-Hydroxy-4-Methyl-5-Nitropyri;4-METHYL-5-NITRO-2(1H)-PYRIDINONE;4-Methyl-5-nitropyridin-2(1H)-one;4-methyl-5-nitro-1H-pyridin-2-one
CBNumber
CB3193376
Molecular Formula
C6H6N2O3
Formula Weight
154.12
MOL File
21901-41-7.mol
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2-Hydroxy-4-methyl-5-nitropyridine Property

Melting point:
186-190 °C (lit.)
Boiling point:
277.46°C (rough estimate)
Density 
1.4564 (rough estimate)
refractive index 
1.5100 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
Crystalline Powder
pka
8.10±0.10(Predicted)
color 
Yellow to orange
BRN 
136900
CAS DataBase Reference
21901-41-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-20/21/22
Safety Statements 
26-37/39-36/37/39-36
RIDADR 
2811
WGK Germany 
3
HazardClass 
6.1
PackingGroup 
III
HS Code 
29337900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
290106
Product name
2-Hydroxy-4-methyl-5-nitropyridine
Purity
98%
Packaging
5g
Price
$185
Updated
2023/01/07
TCI Chemical
Product number
H1050
Product name
2-Hydroxy-4-methyl-5-nitropyridine
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$31
Updated
2025/07/31
TCI Chemical
Product number
H1050
Product name
2-Hydroxy-4-methyl-5-nitropyridine
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$95
Updated
2025/07/31
TRC
Product number
M218915
Product name
4-Methyl-5-nitro-1,2-dihydropyridin-2-one
Packaging
100mg
Price
$75
Updated
2021/12/16
AK Scientific
Product number
I228
Product name
2-Hydroxy-4-methyl-5-nitropyridine
Packaging
25g
Price
$52
Updated
2021/12/16
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2-Hydroxy-4-methyl-5-nitropyridine Chemical Properties,Usage,Production

Chemical Properties

Orange plates

General Description

The conformational stability and the vibartional analysis of 2-hydroxy-4-methyl-5-nitropyridine was studied.

Synthesis

21901-40-6

21901-41-7

General procedure for the synthesis of 2-hydroxy-4-methyl-5-nitropyridine from 2-amino-4-methyl-5-nitropyridine: 2-amino-4-methyl-5-nitropyridine (10 g, 23 mmol) was weighed and placed in a 250 ml round-bottomed flask, and 70 ml of concentrated sulphuric acid was added to dissolve it until the raw material was completely dissolved. The reaction flask was placed in a cold bath at a low temperature of -5 °C, and a pre-configured aqueous solution of sodium nitrite (NaNO2, 6.76 g) was slowly added dropwise through a constant pressure dropping funnel. A large number of bubbles were generated during the addition, and the rate of titration needed to be controlled to avoid a rapid increase in temperature and to ensure that the reaction temperature did not exceed 0 °C. The reaction was carried out at a constant pressure. A solid was gradually precipitated during the reaction. After dropwise addition, stirring was continued for 10 minutes, and the reaction solution turned orange and clarified. The reaction was continued at 0 °C and the progress of the reaction was monitored by thin layer chromatography (TLC).The reaction was stopped after 3 hours when the TLC showed that the reaction was complete. The reaction solution was slowly poured into a beaker containing about 300 mL of water and a large amount of yellow solid precipitated. After leaving to crystallize for 3 h at room temperature, the solid was collected by filtration and dried under infrared lamp to give 6.72 g of yellow solid product in 67.2% yield.

References

[1] Patent: CN105906621, 2016, A. Location in patent: Paragraph 0045
[2] Patent: EP2366691, 2011, A1. Location in patent: Page/Page column 13
[3] Journal of the Chemical Society, 1954, p. 2448,2455
[4] Journal of Organic Chemistry, 1955, vol. 20, p. 1729,1731
[5] Patent: WO2007/53394, 2007, A1. Location in patent: Page/Page column 12

2-Hydroxy-4-methyl-5-nitropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

3-AMINO-6-CHLORO-4-PICOLINE 2-Bromo-5-nitro-4-picoline
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2-Hydroxy-4-methyl-5-nitropyridine Suppliers

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View Lastest Price from 2-Hydroxy-4-methyl-5-nitropyridine manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
2-Hydroxy-4-methyl-5-nitropyridine 21901-41-7
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-05-29
Hebei Chuanghai Biotechnology Co., Ltd
Product
2-Hydroxy-4-methyl-5-nitropyridine 21901-41-7
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-13
Henan Fengda Chemical Co., Ltd
Product
2-Hydroxy-4-methyl-5-nitropyridine 21901-41-7
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
98%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-08

21901-41-7, 2-Hydroxy-4-methyl-5-nitropyridineRelated Search:

Azamethiphos Methylparaben 2,4,6-Collidine 2,6-Lutidine Methyl salicylate 3-Nitro-2-pyridinol 2-Hydroxy-4-methylpyridine Bensulfuron methyl 2-Bromo-5-nitropyridine 2-Hydroxy-5-nitropyridine METSULFURON METHYL 3-Hydroxypyridine 2-Methyl-5-nitropyridine Methyl acetate CHLOROPHOSPHONAZO III Kresoxim-methyl Methyl propyl carbonate 2-Chloro-3-hydroxypyridine

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