4'-(2-Methylpropyl)acetophenone

Product Name: 4'-(2-Methylpropyl)acetophenone
CAS No.: 38861-78-8
Chemical Name: 4'-(2-Methylpropyl)acetophenone
Synonyms: 1-(4-ISOBUTYLPHENYL)ETHAN-1-ONE;4-ISOBUTYLACETOPHENONE;1-(4-ISOBUTYLPHENYL)ETHANONE;4-IBAP;Nsc173015;1Y1&1R DV1;Ibuprofen-4;IBUPROFEN IMP E;p-Isobutylacetoph;TIMTEC-BB SBB007668
CBNumber: CB3210390
Molecular Formula: C12H16O
Formula Weight: 176.25
MOL File: 38861-78-8.mol

More

Less

4'-(2-Methylpropyl)acetophenone Property

Boiling point:: 134-135°C 16mm
Density: 0,952 g/cm³
vapor pressure: 0.75Pa at 20℃
refractive index: 1.5180
Flash point:: 54°C
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: soluble in Dichloromethane; Diethyl Ether; Ethyl Acetate; THF
form: liquid
color: Colorless to Yellow
Water Solubility: Miscible with chloroform and methanol. Slightly miscible with water.
BRN: 1935275
InChI: InChI=1S/C12H16O/c1-9(2)8-11-4-6-12(7-5-11)10(3)13/h4-7,9H,8H2,1-3H3
InChIKey: KEAGRYYGYWZVPC-UHFFFAOYSA-N
SMILES: C(=O)(C1=CC=C(CC(C)C)C=C1)C
LogP: 3.4 at 23℃
CAS DataBase Reference: 38861-78-8(CAS DataBase Reference)
NIST Chemistry Reference: 4'-(2-Methylpropyl)acetophenone(38861-78-8)
EPA Substance Registry System: Ethanone, 1-[4-(2-methylpropyl)phenyl]- (38861-78-8)

More

Less

Safety

Hazard Codes: Xn,N,Xi
Risk Statements: 10-40-52/53-43
Safety Statements: 16-36-22-61-36/37
RIDADR: 1224
WGK Germany: 3
TSCA: Yes
HazardClass: 3.2
PackingGroup: III
HS Code: 29143990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P272Contaminated work clothing should not be allowed out of the workplace.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR1146
Product name: 4′-Isobutylacetophenone
Packaging: 500mg
Price: $131.1
Updated: 2025/07/31

Sigma-Aldrich

Product number: BP557
Product name: 4′-Isobutylacetophenone
Purity: British Pharmacopoeia (BP) Reference Standard
Packaging: 100MG
Price: $227
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1335541
Product name: Ibuprofen Related Compound C
Packaging: 3x0.2ml
Price: $1470
Updated: 2025/07/31

TCI Chemical

Product number: I0417
Product name: 4'-Isobutylacetophenone
Purity: >96.0%(GC)
Packaging: 25mL
Price: $72
Updated: 2025/07/31

TCI Chemical

Product number: I0417
Product name: 4'-Isobutylacetophenone
Purity: >96.0%(GC)
Packaging: 100mL
Price: $197
Updated: 2025/07/31

More

Less

4'-(2-Methylpropyl)acetophenone Chemical Properties,Usage,Production

Chemical Properties

Clear Colourless Oil

Uses

4'-isobutylacetophenone is an important starting material employed in the production of pharmaceuticals such as ibuprofen. It is also utilized in proteomics research. It is used as an intermediate in organic synthesis.

Uses

A degradation product of Ibuprofen in tablets, which is a known toxin. Ibuprofen (I140000) impuritiy.

Preparation

Synthesis of 4-isobutylacetophenone: toluene and propylene are reacted with the participation of metal potassium, sodium carbonate and graphite, Alkylation on methyl to generate isobutylbenzene, Then with acetyl chloride in the participation of anhydrous aluminum trichloride to obtain the product.

General Description

4'-(2-Methylpropyl)acetophenone, also known as Ibuprofen EP Impurity E, is an impurity of ibuprofen. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). It works by blocking your body's production of certain natural substances that cause inflammation.

4'-(2-Methylpropyl)acetophenone Preparation Products And Raw materials

Raw materials

Isobutylbenzene Aluminum chloride Potassium Graphite

Preparation Products

More

Less

4'-(2-Methylpropyl)acetophenone Suppliers

Americas 1 Belgium 2 Canada 2 China 254 Europe 3 France 1 Germany 4 India 41 Japan 2 Norway 1 Ukraine 1 United Kingdom 17 United States 40 Global 369

Molekula Limited

Tel: --
Fax: --
Email: o@molekula.com
Country: United Kingdom
ProdList: 6127
Advantage: 58

Manchester Organics

Tel: --
Fax: --
Email: info@manchesterorganics.com
Country: United Kingdom
ProdList: 6834
Advantage: 67

Biosynth Carbosynth

Tel: --
Fax: --
Email: ales@carbosynth.com
Country: United Kingdom
ProdList: 2598
Advantage: 58

Apollo Scientific Ltd.

Tel: --
Fax: --
Email: sales@apolloscientific.co.uk
Country: United Kingdom
ProdList: 6084
Advantage: 88

CMS Chemicals Limited

Tel: --
Fax: --
Email: cms.marketing@cms-chemicals.com
Country: United Kingdom
ProdList: 3708
Advantage: 60

Tokyo Chemical Industry UK Ltd.

Tel: --
Fax: --
Email: sales@tci-uk.co.uk
Country: United Kingdom
ProdList: 1637
Advantage: 50

Apin Chemicals Limited (UK)

Tel: --
Fax: --
Email: info@apinchemicals.com
Country: United Kingdom
ProdList: 6184
Advantage: 60

Whyte Chemicals

Tel: --
Fax: --
Email: sales@whytechemicals.co.uk
Country: United Kingdom
ProdList: 3748
Advantage: 50

Carbosynth Limited

Tel: --
Fax: --
Email: sales@carbosynth.com
Country: United Kingdom
ProdList: 6581
Advantage: 61

Leancare Ltd.

Tel: --
Fax: --
Email: enquiry@leancare.co.uk
Country: United Kingdom
ProdList: 6446
Advantage: 42

CARBONE SCIENTIFIC CO.,LTD

Tel: --
Fax: --
Email: sales@carbonesci.com
Country: United Kingdom
ProdList: 6666
Advantage: 30

MOLEKULA Ltd.

Tel: --
Fax: --
Email: kevinbanks@molekula.com
Country: United Kingdom
ProdList: 6140
Advantage: 66

UK GREEN SCIENTIFIC CO.,LIMITED

Tel: --
Fax: --
Email: sales@gs-chem.com
Country: United Kingdom
ProdList: 6098
Advantage: 47

Eurolabs Limited

Tel: --
Fax: --
Country: United Kingdom
ProdList: 6309
Advantage: 46

MDA Chemicals Ltd.

Tel: --
Fax: --
Email: sheila@mda-chem.co.uk
Country: United Kingdom
ProdList: 1961
Advantage: 30

Apin Chemicals Ltd.

Tel: --
Fax: --
Email: info@apinchemicals.com
Country: United Kingdom
ProdList: 6807
Advantage: 42

VWR International

Tel: --
Fax: --
Email: solutions@vwr.com
Country: United Kingdom
ProdList: 6548
Advantage: 82

More

Less

View Lastest Price from 4'-(2-Methylpropyl)acetophenone manufacturers

Hebei Yiduo Import and Export Co., Ltd.

Product: 4'-(2-Methylpropyl)acetophenone 38861-78-8
Price: US $100.00-80.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000000
Release date: 2025-03-12

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4'-(2-Methylpropyl)acetophenone 38861-78-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2025-03-13

Guangzhou Tosun Pharmaceutical Limited

Product: Ibuprofen EP Impurity E 38861-78-8
Price: US $0.00/mg
Min. Order: 1mg
Purity: above 96%
Supply Ability: 50kg
Release date: 2023-05-09

38861-78-8, 4'-(2-Methylpropyl)acetophenoneRelated Search:

Ibuprofen 1-Hydroxyibuprofen (S)-(+)-Ibuprofen 1-Oxo Ibuprofen Ibuprofen Ethyl Ester 2-[4-(2-Methylpropyl)phenyl] ethanol 6-isobutyl-3-methyl-2,3-dihydro-1H-inden-1-one 2-(4-Methylphenyl)propanoic acid (2RS)-2-(4-BUTYLPHENYL)PROPANOIC ACID rac 2-Hydroxy Ibuprofen 4-(2-Methylpropyl)benzeneethanol (R)-(-)-IBUPROFEN Ibuprofen EP Impurity I 3-(4-ISOBUTYL-PHENYL)-PROPIONIC ACID p-Isobutylstyrene rac-Ibuprofen amide rac a-Hydroxy Ibuprofen (2RS)-2-(4-FORMYLPHENYL)PROPANOIC ACID Ibuprofen Impurity E

Imp. E:1-(4-isobutylphenyl)ethanone

TIMTEC-BB SBB007668

P-ISO-BUTYLACETOPHENONE

IBUPROFEN IMPURITY E

IBUPROFEN IMP E

ISOBUTYL ACETOPHENONE

4'-Isobutylacetophenone, 97+%

4'-ISOBUTYLACETOPHENONE

4-ISOBUTYLACETOPHENONE

1-[4-(2-METHYLPROPYL)PHENYL]ETHANONE

1-(4-ISOBUTYLPHENYL)ETHAN-1-ONE

1-(4-ISOBUTYLPHENYL)ETHANONE

1-[4-(2-methylpropyl)phenyl]-ethanon

4-Isobutylacetaphenone

1-[4-(2-methylpropyl)phenyl]ethan-1-one

1-(4-(2-METHYLPROPYL)PHENYL)ETNANONE

4'-(2-Methylpropyl)acetophenone

4-lsobutylacetophenone

Acetophenone, 4-isobutyl-

Ethanone, 1-[4-(2-methylpropyl)phenyl]-

Nsc173015

p-Isobutylacetoph

Ibuprofen IMpurity-E(EP)

4'-(2-Methylpropyl)a

1-[4-(2-Methylprop-1-yl)phenyl]ethan-1-one, 1-(4-Isobutylphenyl)ethan-1-one

Ibuprofen Related CoMpound C, USP

3 ampules) (4-isobutylacetophenone)

4-ISOBUTYLACETOPHENONE(Ibuprofen Related Compound C)(Ibuprofen Impurity E)

1Y1&1R DV1

Ibuprofen-4

Ibuprofen Related Compound C (0.2 mL/ampule

1-[4-(2-Methylpropyl)phenyl]-1-ethanone

1-Acetyl-4-isobutylbenzene

p-Acetylisobutylbenzene

Ibuprofen EP Impurity E

4-IBAP

Ibuprofen USP Related Compound C

Ibuprofen EP Impurity E：Ibuprofen Impurity E

4'-Isobutylacetophenone&gt

4-Isobutylacetophenone（Ibuprofen Impurity）

Ibuprofen Impurity 5（Ibuprofen EP Impurity E）

Ibuprofen Impurity E/4-isobutylacetophenone

Ibuprofen EP Impurity E/ Ibuprofen Related Compound C

Ibuprofen USP Related Compound CQ: What is Ibuprofen USP Related Compound C Q: What is the CAS Number of Ibuprofen USP Related Compound C Q: What is the storage condition of Ibuprofen USP Related Compound C Q: What are the applications of Ibuprofen USP Related Compound C

Ibuprofen EP Impurit

4'-Isobutylacetophenone, ≥ 96.0%

4’-Isobutylacetophenone

4''-(2-Methylpropyl)acetophenone

4'-Isobutylacetophenone 98.5%

Ibuprofen EP Impurity E (Ibuprofen USP Related Compound C)

38861-78-8

Aromatic Acetophenones & Derivatives (substituted)

Aromatics, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals

Aromatics

Impurities

Intermediates & Fine Chemicals

Pharmaceuticals