4-Hydroxybenzyl alcohol Property

Melting point:

114-122 °C(lit.)

Boiling point:

251-253°C

Density 

1.1006 (rough estimate)

refractive index 

1.5035 (estimate)

FEMA 

3987 | 4-HYDROXYBENZYL ALCOHOL

Flash point:

251-253°C

storage temp. 

Store below +30°C.

solubility 

6.7g/l soluble

form 

Crystalline Powder

pka

pK1:9.82 (25°C)

color 

Pink to beige

Odor

at 100.00 %. fruity bitter almond sweet coconut

Odor Type

fruity

Water Solubility 

Soluble in water (6.7 mg/ml at 20°C), dioxane (100 mg/ml), 1N NaOH (50 mg/ml), DMSO, and methanol.

Sensitive 

Light Sensitive/Air Sensitive

JECFA Number

955

BRN 

1858967

InChIKey

BVJSUAQZOZWCKN-UHFFFAOYSA-N

LogP

0.21

CAS DataBase Reference

623-05-2(CAS DataBase Reference)

NIST Chemistry Reference

Benzenemethanol, 4-hydroxy-(623-05-2)

EPA Substance Registry System

4-Hydroxybenzenemethanol (623-05-2)

Safety

Hazard Codes 

Xi

Risk Statements 

36-36/37/38

Safety Statements 

26-24/25-36

WGK Germany 

3

RTECS 

DA4796800

F 

8-9-23

Hazard Note 

Irritant/Keep Cold/Air Sensitive/Light Sensitive

HS Code 

29072900

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H319Causes serious eye irritation

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

4-Hydroxybenzyl alcohol Chemical Properties,Usage,Production

Chemical Properties

Pink to beige crystalline powder

Chemical Properties

4-Hydroxybenzyl alcohol is a white crystalline powder with slightly fruity-sweet coconut odor

Occurrence

Reportedly found in vanilla, Bourbon (Vanilla plantifolia Andrew

Uses

4-Hydroxybenzyl alcohol is also used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff.

Preparation

Prepared from p-cresol by using the microorganism, Pseudomonas putida.

Definition

ChEBI: A member of the class of benzyl alcohols that is benzyl alcohol substituted by a hydroxy group at position 4. It has been isolated from Arcangelisia gusanlung.

General Description

4-Hydroxybenzyl alcohol (HBA) is a phenolic compound found in Gastrodia elata. It is as an antioxidant and anti-asthmatic agent.

Flammability and Explosibility

Not classified

Contact allergens

Methylol phenols are sensitizers contained in resins based on phenol and formaldehyde of the resol type. Cross-reactivity is possible with other phenol derivative molecules.

Purification Methods

Crystallise the alcohol from H2O, *C6H6 (m 124o), *C6H6/EtOH or ClCH2CH2Cl (m 122o). [Beilstein 6 III 4546, 6 IV 5909.]