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4-METHYLTHIOPHENE-3-CARBOXYLIC ACID

Product Name
4-METHYLTHIOPHENE-3-CARBOXYLIC ACID
CAS No.
78071-30-4
Chemical Name
4-METHYLTHIOPHENE-3-CARBOXYLIC ACID
Synonyms
4-Methylthiophen-3-carboxylic acid;4-methyl-3-Thiophenecarboxylic acid;4-METHYLTHIOPHENE-3-CARBOXYLIC ACID;3-Thiophenecarboxylic acid, 4-methyl-
CBNumber
CB32446874
Molecular Formula
C6H6O2S
Formula Weight
142.18
MOL File
78071-30-4.mol
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4-METHYLTHIOPHENE-3-CARBOXYLIC ACID Property

Melting point:
136-138 ºC
Boiling point:
274 ºC
Density 
1.319
Flash point:
119 ºC
storage temp. 
2-8°C(protect from light)
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
4.18±0.20(Predicted)
color 
White to Off-White
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Safety

HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC
Product number
B101806
Product name
4-methylthiophene-3-carboxylicacid
Packaging
2.5g
Price
$45
Updated
2021/12/16
TRC
Product number
B101806
Product name
4-methylthiophene-3-carboxylicacid
Packaging
25g
Price
$70
Updated
2021/12/16
Ark Pharm
Product number
P000269518
Product name
4-Methylthiophene-3-carboxylic acid
Purity
97%
Packaging
250mg
Price
$84
Updated
2021/12/16
Oakwood
Product number
224039
Product name
4-Methylthiophene-3-carboxylicacid
Purity
98%
Packaging
250mg
Price
$89
Updated
2021/12/16
ChemScene
Product number
CS-W019951
Product name
4-Methylthiophene-3-carboxylicacid
Purity
99.87%
Packaging
1g
Price
$141
Updated
2021/12/16
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4-METHYLTHIOPHENE-3-CARBOXYLIC ACID Chemical Properties,Usage,Production

Synthesis

30318-99-1

124-38-9

78071-30-4

At -78 °C, n-butyllithium (n-BuLi, 1.6 M hexane solution, 14.6 mL, 23.3 mmol) was slowly added dropwise to a stirred solution of 3-bromo-4-methylthiophene (2.7 g, 15.6 mmol) in tetrahydrofuran (THF, 35 mL). After the dropwise addition was completed, the reaction mixture was kept stirred at -78 °C for 15 minutes, followed by continued stirring for 30 minutes. Next, carbon dioxide gas (CO2) was passed into the reaction mixture for 10 minutes and stirring was continued at the same temperature for 20 minutes. Upon completion of the reaction, the mixture was slowly warmed to 0 °C and the reaction was quenched with 1 M aqueous sodium hydroxide (NaOH) solution (60 mL), followed by washing with ethyl acetate (EtOAc, 2 x 50 mL). The aqueous phase was acidified to pH about 5 and extracted with dichloromethane (DCM, 2 × 50 mL). The organic layers were combined, washed sequentially with water (100 mL) and saturated saline (100 mL), dried over anhydrous sodium sulfate (Na2SO4), and concentrated under reduced pressure. Finally, the residue was purified by column chromatography (silica gel as stationary phase, 8% methanol/dichloromethane as eluent) to afford the target product 4-methylthiophene-3-carboxylic acid (1.5 g, 70% yield) as a white solid.

References

[1] Patent: WO2015/129926, 2015, A1. Location in patent: Page/Page column 78

4-METHYLTHIOPHENE-3-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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4-METHYLTHIOPHENE-3-CARBOXYLIC ACID Suppliers

China 85 India 1 United States 5 Global 91
JinYan Chemicals(ShangHai) Co.,Ltd.
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025-83697070
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+86-25-83453306
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info@chemlin.com.cn
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0531-88811783
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+86 (531) 55696010 QQ 1762738062
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Zaozhuang Benefit Chemical Co., Ltd.
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Bide Pharmatech Ltd.
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78071-30-4, 4-METHYLTHIOPHENE-3-CARBOXYLIC ACIDRelated Search:

ETHYL 2-AMINO-4-METHYLTHIOPHENE-3-CARBOXYLATE 2-AMINO-4-PHENYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER 2-AMINO-4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBOXYLIC ACID METHYL ESTER ETHYL 2-AMINO-4,5-DIMETHYLTHIOPHENE-3-CARBOXYLATE 2-AMINO-5,6-DIHYDRO-4H-CYCLOPENTA[B]THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER THIOPHENE-3,4-DICARBOXYLIC ACID DIETHYL 5-AMINO-3-METHYL-2,4-THIOPHENEDICARBOXYLATE ETHYL 2-[(2-CHLOROACETYL)AMINO]-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXYLATE ETHYL 2-AMINO-4-(2-FURYL)THIOPHENE-3-CARBOXYLATE ETHYL 2-AMINO-4-(2-THIENYL)THIOPHENE-3-CARBOXYLATE ETHYL 2-ACETAMIDO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE 3-AMINO-4H-THIENO[3,4-C]CHROMEN-4-ONE ethyl 5-acetyl-2-amino-4-methyl-thiophene-3-carboxylate AKOS 89941 BUTTPARK 91\08-100 ETHYL 2-[(2-CHLOROACETYL)AMINO]-4-METHYLTHIOPHENE-3-CARBOXYLATE ETHYL 2-[2-(2,4-DICHLOROPHENOXY)ACETAMIDO]-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE AURORA 3766

  • 4-METHYLTHIOPHENE-3-CARBOXYLIC ACID
  • 4-methyl-3-Thiophenecarboxylic acid
  • 3-Thiophenecarboxylic acid, 4-methyl-
  • 4-Methylthiophen-3-carboxylic acid
  • 78071-30-4