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Isepamicine

Product Name
Isepamicine
CAS No.
58152-03-7
Chemical Name
Isepamicine
Synonyms
hapa-b;sch21420;isepamicin;ISEPAMICINE;hapa-gentamycinb;ISEPAMICIN SULPHATE;Isepamicine USP/EP/BP;(s)-y-1-oxopropyl)-2-deoxy;Isepamicin Sulfate Impurity Ⅲ:Isepamicine;Isepamicin Sulfate Impurity Ⅲ:Isepamicine
CBNumber
CB3245233
Molecular Formula
C22H43N5O12
Formula Weight
569.6
MOL File
58152-03-7.mol
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Isepamicine Property

Boiling point:
633.08°C (rough estimate)
Density 
1.3531 (rough estimate)
refractive index 
1.7500 (estimate)
pka
11.01±0.35(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biorbyt Ltd
Product number
orb134569
Product name
Isepamicin
Purity
>99%
Packaging
100mg
Price
$510
Updated
2021/12/16
Biorbyt Ltd
Product number
orb134569
Product name
Isepamicin
Purity
>99%
Packaging
250mg
Price
$765
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
ING0005409
Product name
ISEPAMICIN
Purity
95.00%
Packaging
250MG
Price
$1146.05
Updated
2021/12/16
Biorbyt Ltd
Product number
orb134569
Product name
Isepamicin
Purity
>99%
Packaging
1g
Price
$1504.5
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
ING0005409
Product name
ISEPAMICIN
Purity
95.00%
Packaging
1G
Price
$1758.49
Updated
2021/12/16
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Isepamicine Chemical Properties,Usage,Production

Description

Isepamicin is a aminoglycoside antibiotic indicated for use in the treatment of urinary and respiratory tract infections. Although it is less potent than most other aminoglycosides, it is also less nephrotoxic. The broad-spectrum activity of isepamicin generally parallels that of amikacin in vitro.

Originator

Schering Plough (USA)

Uses

Antibacterial (aminoglyco side).

brand name

Isepacin; Exacin

Antimicrobial activity

Hydroxyamino propionyl gentamicin B. A semisynthetic derivative of gentamicin B, modified to render it more resistant to microbial inactivation.
In-vitro activity is comparable to or slightly greater than amikacin against Staph. aureus and most enterobacteria; it is much more active against Ser. marcescens, Enterobacter spp. and Klebsiebella pneumoniae. It is also active in vitro against the Mycobacterium avium complex and Nocardia asteroides. It is less susceptible than amikacin or gentamicin to inactivation by β-lactam antibiotics. It retains activity against some strains resistant to most other aminoglycosides.
Pharmacokinetics in neonatal, pediatric, adult, elderly and renally impaired patients are similar to those of other aminoglycosides. In adult volunteers the plasma half-life was 2.1 h. Clearance is reduced in neonates and the elderly. A 7.5 mg/kg once-daily dosage is recommended for children less than 16 days old. No dosage adjustment is required for the elderly unless renal function is impaired. Clearance is proportional to creatinine clearance in patients with chronic renal impairment, and it is eliminated by hemodialysis.
It has been used in respiratory tract infections, urinary tract infections and intra-abdominal infections, in adults and children. It appears to be as effective and well tolerated as amikacin. It is available in Japan.

Isepamicine Preparation Products And Raw materials

Raw materials

Preparation Products

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Isepamicine Suppliers

Chembest Research Laboratories Limited
Tel
021-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
5997
Advantage
61
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
19982
Advantage
64
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12338
Advantage
58
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9901
Advantage
58
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2784
Advantage
58
ChemStrong Scientific Co.,Ltd
Tel
0755-66853366 15920483169
Email
sales@chem-strong.com
Country
China
ProdList
18437
Advantage
56
AdooQ Bioscience CHINA
Tel
025-58849295
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
3004
Advantage
60
Hubei Jusheng Technology Co.,Ltd
Tel
027-59599241 18871490274
Fax
027-59599241
Email
1400878000@qq.com
Country
China
ProdList
9824
Advantage
58
Intelligence Pharm Science(Shanghai) Co., Ltd.
Tel
021-57898186
Fax
021-37699262
Country
China
ProdList
449
Advantage
55
Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.
Tel
027-51831887 15337167856
Fax
027-51837635 QQ1165326703
Email
hubeixinyuanshun@163.com
Country
China
ProdList
10305
Advantage
58
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View Lastest Price from Isepamicine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Isepamicine 58152-03-7
Price
US $1.00-1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
50tons
Release date
2020-05-07
Zhuozhou Wenxi import and Export Co., Ltd
Product
Isepamicine 58152-03-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27
Dideu Industries Group Limited
Product
Isepamicine 58152-03-7
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-06-21

58152-03-7, IsepamicineRelated Search:


  • (s)-y-1-oxopropyl)-2-deoxy
  • hapa-b
  • hapa-gentamycinb
  • 4-O-(6-Amino-6-deoxy-α-D-glucopyranosyl)-6-O-[4-C-methyl-3-(methylamino)-3-deoxy-β-L-arabinopyranosyl]-N1-[(S)-3-amino-2-hydroxypropionyl]-2-deoxy-D-streptamine
  • Isepamicin Sulfate Impurity Ⅲ:Isepamicine
  • isepamicin
  • sch21420
  • thyl-3-(methylamino)-beta-l-arabinopyranosyl-(1-6))-n(sup1)-(3-amino-2-hydrox
  • ISEPAMICIN SULPHATE
  • (S)-O-6-amino-6-deoxy-alpha-D-glucopyranosyl-(1->4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1->6)]-1,3-diamino-N1-(3-aminolactoyl)-1,2,3-trideoxy-D-scyllo-inositol
  • D-Streptamine, O-6-amino-6-deoxy-a-D-glucopyranosyl-(14)-O-[3-deoxy-4-C-methyl-3-(methylamino)-b-L-arabinopyranosyl-(16)]-N1-(3-amino-2-hydroxy-1-oxopropyl)-2-deoxy-, (S)-
  • D-Streptamine, O-6-amino-6-deoxy-a-D-glucopyranosyl-(14)-O-[3-deoxy-4-C-methyl-3-(methylamino)-b-L-arabinopyranosyl-(16)]-N1-[(2S)-3-amino-2-hydroxy-1-oxopropyl]-2-deoxy- (9CI)
  • ISEPAMICINE
  • (2S)-3-Amino-N-[(1R,2S,3S,4R,5S)-5-amino-4-[(3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxyoxan-2-yl]oxy-2-[(3R,4R,5R)-3,5-dihydroxy-5-methyl-4-methylaminooxan-2-yl]oxy-3-hydroxycyclohexyl]-2-hydroxypropanamide
  • (S)-O-6-Amino-6-deoxy-α-D-glucopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyrano-syl-(1→6)]-N^<1>^-(3-amino-2-hydroxy-1-oxopropyl)-2-deoxy-D-streptamine
  • 4-O-(6-Amino-6-deoxy-α-D-glucopyranosyl)-6-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl]-N1-[(S)-3-amino-2-hydroxy-1-oxopropyl]-2-deoxy-D-streptamine
  • 4-O-(6-Amino-6-deoxy-α-D-glucopyranosyl)-6-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl]-N1-[(S)-3-amino-2-hydroxypropanoyl]-2-deoxy-D-streptamine
  • D-Streptamine, O-6-amino-6-deoxy-α-D-glucopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)]-N1-[(2S)-3-amino-2-hydroxy-1-oxopropyl]-2-deoxy-
  • Isepamicine USP/EP/BP
  • (S)-O-6-amino-6-deoxy-alpha-D-glucopyranosyl-(1->4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1->6)]-1,3-diamino-N1-(3-aminolactoyl)-1,2,3-trideoxy-D-scyllo-inositol
  • Isepamicin Sulfate Impurity Ⅲ:Isepamicine
  • 58152-03-7
  • C22H43N5O12