ChemicalBook > CAS DataBase List > Isepamicine

Isepamicine

Product Name
Isepamicine
CAS No.
58152-03-7
Chemical Name
Isepamicine
Synonyms
hapa-b;sch21420;isepamicin;ISEPAMICINE;hapa-gentamycinb;ISEPAMICIN SULPHATE;Isepamicine USP/EP/BP;(s)-y-1-oxopropyl)-2-deoxy;Isepamicin Sulfate Impurity Ⅲ:Isepamicine;Isepamicin Sulfate Impurity Ⅲ:Isepamicine
CBNumber
CB3245233
Molecular Formula
C22H43N5O12
Formula Weight
569.6
MOL File
58152-03-7.mol
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Isepamicine Property

Boiling point:
633.08°C (rough estimate)
Density 
1.3531 (rough estimate)
refractive index 
1.7500 (estimate)
pka
11.01±0.35(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biorbyt Ltd
Product number
orb134569
Product name
Isepamicin
Purity
>99%
Packaging
100mg
Price
$510
Updated
2021/12/16
Biorbyt Ltd
Product number
orb134569
Product name
Isepamicin
Purity
>99%
Packaging
250mg
Price
$765
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
ING0005409
Product name
ISEPAMICIN
Purity
95.00%
Packaging
250MG
Price
$1146.05
Updated
2021/12/16
Biorbyt Ltd
Product number
orb134569
Product name
Isepamicin
Purity
>99%
Packaging
1g
Price
$1504.5
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
ING0005409
Product name
ISEPAMICIN
Purity
95.00%
Packaging
1G
Price
$1758.49
Updated
2021/12/16
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Isepamicine Chemical Properties,Usage,Production

Description

Isepamicin is a aminoglycoside antibiotic indicated for use in the treatment of urinary and respiratory tract infections. Although it is less potent than most other aminoglycosides, it is also less nephrotoxic. The broad-spectrum activity of isepamicin generally parallels that of amikacin in vitro.

Originator

Schering Plough (USA)

Uses

Antibacterial (aminoglyco side).

brand name

Isepacin; Exacin

Antimicrobial activity

Hydroxyamino propionyl gentamicin B. A semisynthetic derivative of gentamicin B, modified to render it more resistant to microbial inactivation.
In-vitro activity is comparable to or slightly greater than amikacin against Staph. aureus and most enterobacteria; it is much more active against Ser. marcescens, Enterobacter spp. and Klebsiebella pneumoniae. It is also active in vitro against the Mycobacterium avium complex and Nocardia asteroides. It is less susceptible than amikacin or gentamicin to inactivation by β-lactam antibiotics. It retains activity against some strains resistant to most other aminoglycosides.
Pharmacokinetics in neonatal, pediatric, adult, elderly and renally impaired patients are similar to those of other aminoglycosides. In adult volunteers the plasma half-life was 2.1 h. Clearance is reduced in neonates and the elderly. A 7.5 mg/kg once-daily dosage is recommended for children less than 16 days old. No dosage adjustment is required for the elderly unless renal function is impaired. Clearance is proportional to creatinine clearance in patients with chronic renal impairment, and it is eliminated by hemodialysis.
It has been used in respiratory tract infections, urinary tract infections and intra-abdominal infections, in adults and children. It appears to be as effective and well tolerated as amikacin. It is available in Japan.

Isepamicine Preparation Products And Raw materials

Raw materials

Ammonium hydroxide Trifluoroacetic acid Isepamicin sulfate

Preparation Products

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View Lastest Price from Isepamicine manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Isepamicine 58152-03-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27
Career Henan Chemical Co
Product
isepamicin 58152-03-7
Price
US $1.00/g
Min. Order
1g
Purity
95-99%
Supply Ability
1ton
Release date
2020-01-10
Career Henan Chemical Co
Product
Isepamicine 58152-03-7
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
200kg
Release date
2020-01-10

58152-03-7, IsepamicineRelated Search:

6-Aminocaproic acid Tris(hydroxymethyl)aminomethane ALTRENOGEST Glycine Omeprazole magnesium Isepamicin sulfate Miboplatin 4-ACETAMIDOCYCLOHEXANOL GENTAMICIN B N-(3-AMINOPROPYL)CYCLOHEXYLAMINE (1R,2R)-2-(PROPYLAMINO)CYCLOHEXANOL (1R,2R)-2-(ETHYLAMINO)CYCLOHEXANOL METHYL 6-AMINO-6-DEOXY-GALACTOPYRANOSIDE 4-O-(6-Amino-6-deoxy-α-D-glucopyranosyl)-2-deoxy-D-streptamine AMINO ACIDS Isepamicine METHYL 6-AMINO-6-DEOXY-GALACTOPYRANOSIDE Nojirimycin

  • (s)-y-1-oxopropyl)-2-deoxy
  • hapa-b
  • hapa-gentamycinb
  • 4-O-(6-Amino-6-deoxy-α-D-glucopyranosyl)-6-O-[4-C-methyl-3-(methylamino)-3-deoxy-β-L-arabinopyranosyl]-N1-[(S)-3-amino-2-hydroxypropionyl]-2-deoxy-D-streptamine
  • Isepamicin Sulfate Impurity Ⅲ:Isepamicine
  • isepamicin
  • sch21420
  • thyl-3-(methylamino)-beta-l-arabinopyranosyl-(1-6))-n(sup1)-(3-amino-2-hydrox
  • ISEPAMICIN SULPHATE
  • (S)-O-6-amino-6-deoxy-alpha-D-glucopyranosyl-(1->4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1->6)]-1,3-diamino-N1-(3-aminolactoyl)-1,2,3-trideoxy-D-scyllo-inositol
  • D-Streptamine, O-6-amino-6-deoxy-a-D-glucopyranosyl-(14)-O-[3-deoxy-4-C-methyl-3-(methylamino)-b-L-arabinopyranosyl-(16)]-N1-(3-amino-2-hydroxy-1-oxopropyl)-2-deoxy-, (S)-
  • D-Streptamine, O-6-amino-6-deoxy-a-D-glucopyranosyl-(14)-O-[3-deoxy-4-C-methyl-3-(methylamino)-b-L-arabinopyranosyl-(16)]-N1-[(2S)-3-amino-2-hydroxy-1-oxopropyl]-2-deoxy- (9CI)
  • ISEPAMICINE
  • (2S)-3-Amino-N-[(1R,2S,3S,4R,5S)-5-amino-4-[(3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxyoxan-2-yl]oxy-2-[(3R,4R,5R)-3,5-dihydroxy-5-methyl-4-methylaminooxan-2-yl]oxy-3-hydroxycyclohexyl]-2-hydroxypropanamide
  • (S)-O-6-Amino-6-deoxy-α-D-glucopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyrano-syl-(1→6)]-N^<1>^-(3-amino-2-hydroxy-1-oxopropyl)-2-deoxy-D-streptamine
  • 4-O-(6-Amino-6-deoxy-α-D-glucopyranosyl)-6-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl]-N1-[(S)-3-amino-2-hydroxy-1-oxopropyl]-2-deoxy-D-streptamine
  • 4-O-(6-Amino-6-deoxy-α-D-glucopyranosyl)-6-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl]-N1-[(S)-3-amino-2-hydroxypropanoyl]-2-deoxy-D-streptamine
  • D-Streptamine, O-6-amino-6-deoxy-α-D-glucopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)]-N1-[(2S)-3-amino-2-hydroxy-1-oxopropyl]-2-deoxy-
  • Isepamicine USP/EP/BP
  • (S)-O-6-amino-6-deoxy-alpha-D-glucopyranosyl-(1->4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1->6)]-1,3-diamino-N1-(3-aminolactoyl)-1,2,3-trideoxy-D-scyllo-inositol
  • Isepamicin Sulfate Impurity Ⅲ:Isepamicine
  • 58152-03-7
  • C22H43N5O12