Retaspimycin Hydrochloride

Product Name: Retaspimycin Hydrochloride
CAS No.: 857402-63-2
Chemical Name: Retaspimycin Hydrochloride
Synonyms: Ipi-504;Ipi 504;Unii-928Q33Q049;Retaspimycin HCl;IPI-504;IPI504;IPI 504;Retaspimycin hydrochloride;IPI-504 (Retaspimycin HCl);IPI-504 (RetaspiMycin hydrochloride);17-Allylamino-17-demethoxygeldanamycin hydroquinone hydrochloride;18,21-Didehydro-17-demethoxy-18,21-dideoxo-18,21-dihydroxy-17-(2-propen-1-ylamino)geldanamycin hydrochloride
CBNumber: CB32496253
Molecular Formula: C31H47N3O8.ClH
Formula Weight: 626.186
MOL File: 857402-63-2.mol

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Retaspimycin Hydrochloride Property

storage temp.: Store at -20°C
solubility: ≥26.1 mg/mL in DMSO with gentle warming; insoluble in H2O; ≥100 mg/mL in EtOH with ultrasonic
form: solid
color: Off-white to pink

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0652
Product name: Retaspimycin(Hydrochloride)
Purity: 98.35%
Packaging: 5mg
Price: $216
Updated: 2021/12/16

ApexBio Technology

Product number: A4061
Product name: IPI-504(Retaspimycinhydrochloride)
Packaging: 10mg
Price: $315
Updated: 2021/12/16

ChemScene

Product number: CS-0652
Product name: Retaspimycin(Hydrochloride)
Purity: 98.35%
Packaging: 10mg
Price: $330
Updated: 2021/12/16

ApexBio Technology

Product number: A4061
Product name: IPI-504(Retaspimycinhydrochloride)
Packaging: 10mM(in 1mL DMSO)
Price: $350
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611478
Product name: Retaspimycin hydrochloride
Packaging: 5mg
Price: $382.5
Updated: 2021/12/16

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Retaspimycin Hydrochloride Chemical Properties,Usage,Production

Definition

ChEBI: A hydrochloride that is the monohydrochloride salt of retaspimycin. A semi-synthetic water-soluble analogue of geldanamycin used in cancer treatment.

Biological Activity

retaspimycin hydrochloride (also known as ipi-504), a hydroquinone hydrochloride salt derivative of 17-aag, is a novel, potent and selective inhibitor of heat shock protein 90(hsp90) that binds to the amino-terminal atp/adp-binding site of hsp90. as a highly water-soluble version of 17-aag, ipi-504 (solubility > 200 mg/ml) does not need prior dissolution in organic solvents and hence can be delivered in high concentrations. once in the systemic circulation, ipi-504 is deprotonated and converted into the free base ipi-504 which is subsequently oxidized to 17-aag. ipi-504 potently inhibits proliferation in several tumor cell lines with 50% inhibition concentration ic50 values ranging from 10-40 nmol/l and has been used for the treatment of gastrointestinal stromal tumors, soft-tissue sarcomas and non-small cell lung cancer.britt erika hanson and david h vesole. retaspimycin hydrochloride (ipi-504): a novel heat shock protein inhibitor as an anticancer agent. expert opin. investi. drugs (2009) 18(9): 1375-1383david siegel, sundar jagannath, david h. vesole, ivan borello, amitabha mazumder, constantine mitsiades, jill goddard, joi dunbar, emmanuel normant, julian adams, david grayzel, kenneth c. anderson and paul richardson. a phase 1 study of ipi-504 (retaspimycin hydrochloride) in patients with relapsed or relapsed and refractory multiple myeloma. leukemia & lymphoma, 2011; 52(12): 2308-2315ching ching leow, jon chesebrough, karen t. coffman, christine a. fazenbaker, john gooya, david weng, steve coats, dowdy jackson, bahija jallal and yong chang. antitumor efficacy of ipi-504, a selective heat shock protein 90 inhibitor against human epidermal growth factor receptor 2-positive human xenograft models as a single agent and in combination with trastuzumab or lapatinib. mol cancer ther 2009; 8: 2131-2141

target

HSP90

Retaspimycin Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Retaspimycin Hydrochloride Suppliers

China 24 United States 10 Global 34

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View Lastest Price from Retaspimycin Hydrochloride manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Retaspimycin Hydrochloride 857402-63-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Retaspimycin Hydrochloride 857402-63-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

Career Henan Chemical Co

Product: Retaspimycin (Hydrochloride) 857402-63-2
Price: US $1.00/g
Min. Order: 1g
Purity: 95-99%
Supply Ability: 1ton
Release date: 2020-01-10

857402-63-2, Retaspimycin HydrochlorideRelated Search:

Retaspimycin Aniline hydrochloride Trimethylamine hydrochloride PROPAMOCARB HYDROCHLORIDE Betaine hydrochloride Methylamine hydrochloride Dimethylamine hydrochloride Triethylamine hydrochloride

IPI-504;IPI504;IPI 504

17-Allylamino-17-demethoxygeldanamycin hydroquinone hydrochloride

Ipi 504

Ipi-504

Unii-928Q33Q049

18,21-Didehydro-17-demethoxy-18,21-dideoxo-18,21-dihydroxy-17-(2-propen-1-ylamino)geldanamycin hydrochloride

Retaspimycin hydrochloride

IPI-504 (RetaspiMycin hydrochloride)

IPI-504 (Retaspimycin HCl)

Retaspimycin HCl

857402-63-2

C31H46ClN3O8

C31H45N3O8HCl