4'-CHLORO-2'-HYDROXYACETOPHENONE

Product Name: 4'-CHLORO-2'-HYDROXYACETOPHENONE
CAS No.: 6921-66-0
Chemical Name: 4'-CHLORO-2'-HYDROXYACETOPHENONE
Synonyms: 1-(4-Chloro-2-hydroxyphenyl)ethan-1-one;4'-Chloro-2'-hydroxycetophone;4-CHLORO-2-HYDROXYACETOPHENONE;4'-CHLORO-2'-HYDROXYACETOPHENONE;4-Chloro-2-hydroxyacetophenone,97%;4'-Chloro-2'-hydroxyacetophenone >1-(4-CHLORO-2-HYDROXYPHENYL)ETHANONE;Ethanone, 1-(4-chloro-2-hydroxyphenyl)-;1-(4-Chloro-2-hydroxyphenyl)ethan-1-one, 2-Acetyl-5-chlorophenol
CBNumber: CB3251203
Molecular Formula: C8H7ClO2
Formula Weight: 170.59
MOL File: 6921-66-0.mol

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4'-CHLORO-2'-HYDROXYACETOPHENONE Property

Melting point:: 27-30°C
Boiling point:: 120-122°C 10mm
Density: 1.298±0.06 g/cm3(Predicted)
refractive index: 1.5750 to 1.5790
storage temp.: Sealed in dry,Room Temperature
form: powder to lump to clear liquid
pka: 9.20±0.10(Predicted)
color: White or Colorless to Yellow
CAS DataBase Reference: 6921-66-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22-37/38-41
Safety Statements: 26-39
HS Code: 2914790090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: C2968
Product name: 4'-Chloro-2'-hydroxyacetophenone
Purity: >96.0%(GC)
Packaging: 5g
Price: $50
Updated: 2025/07/31

TCI Chemical

Product number: C2968
Product name: 4'-Chloro-2'-hydroxyacetophenone
Purity: >96.0%(GC)
Packaging: 25g
Price: $168
Updated: 2025/07/31

TRC

Product number: C368878
Product name: 1-(4-Chloro-2-hydroxyphenyl)ethanone
Packaging: 100mg
Price: $60
Updated: 2021/12/16

ChemScene

Product number: CS-0040210
Product name: 1-(4-Chloro-2-hydroxyphenyl)ethan-1-one
Purity: 98.93%
Packaging: 10g
Price: $73
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC10750
Product name: 4'-Chloro-2'-hydroxyacetophenone
Packaging: 10g
Price: $75
Updated: 2021/12/16

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4'-CHLORO-2'-HYDROXYACETOPHENONE Chemical Properties,Usage,Production

Preparation

Preparation by Fries rearrangement of 3-chlorophenyl acetate with aluminium chloride,
without solvent at 130–135° (74–75%) ], between 135° and 200° and 175–200° (85–89%)
with solvent, at r.t., in nitrobenzene (88%), in tetrachloroethane (50%) or in chlorobenzene.

Synthesis

99-91-2

6921-66-0

61124-56-9

The general procedure for the synthesis of 4'-chloro-2'-hydroxyacetophenone and 1-(4-chloro-3-hydroxyphenyl)ethanone from p-chloroacetophenone was as follows: 5 mL of acetonitrile was added to the reaction system as a solvent under the protection of an Ar atmosphere, followed by the addition of 2.69 mg (1 × 10^-2 mmol) of 1-methyl-3-cyanoquinoline salt as a photosensitizer and 2.80 mg (6 × 10^ -3 mmol) cobalt oxime complex 2 as cobalt catalyst. Next, 0.2 mmol of 4'-chloroacetophenone (where R1 is COCH3, R4 is Cl, and both R2 and R3 are H) and 2 mmol of H2O were added. the reaction was carried out at room temperature using a high-pressure mercury lamp irradiation for 5 hr. Upon completion of the reaction, the production of H2 was detected by gas chromatography (TCD) and the conversion of benzene was analyzed by gas chromatography (FID). Subsequently, the products were separated by column chromatography and identified using 1H NMR and mass spectrometry (MS) to confirm that the main products were 4'-chloro-2'-hydroxyacetophenone and 4'-chloro-3'-hydroxyacetophenone. The conversion of 4'-chloroacetophenone was 56%, with yields of 14% and 42% for 4'-chloro-2'-hydroxyacetophenone and 4'-chloro-3'-hydroxyacetophenone, respectively, and 56% for H2.

References

[1] Patent: CN107324975, 2017, A. Location in patent: Paragraph 0128-0129

4'-CHLORO-2'-HYDROXYACETOPHENONE Preparation Products And Raw materials

Raw materials

Preparation Products

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4'-CHLORO-2'-HYDROXYACETOPHENONE Suppliers

Americas 1 China 97 Europe 1 Germany 3 India 14 Japan 3 Poland 2 Switzerland 1 The Netherlands 1 United Kingdom 16 United States 19 Global 158

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View Lastest Price from 4'-CHLORO-2'-HYDROXYACETOPHENONE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 4-Chloro-2-hydroxyacetophenone 6921-66-0
Price: US $130.00-240.00/g
Min. Order: 1g
Purity: 99.2%
Supply Ability: 20tons
Release date: 2025-08-13

6921-66-0, 4'-CHLORO-2'-HYDROXYACETOPHENONERelated Search:

4'-CHLORO-2'-HYDROXYACETOPHENONE 1-AMINO-2-CHLORO-4-HYDROXY-9,10-ANTHRACENEDIONE 6-CHLORO-BENZOFURAN-3-ONE α-Chloro-p-hydroxyacetophenone,α-Chloro-4'-hydroxyacetophenone 2-BROMO-5'-CHLORO-2'-HYDROXYACETOPHENONE 2'-CHLORO-4'-HYDROXYACETOPHENONE 3'-Chloro-2'-hydroxyacetophenone 3',5'-DICHLORO-2'-HYDROXYACETOPHENONE 2'-CHLORO-4'-HYDROXYACETOPHENONE 3'-BROMO-5'-CHLORO-2'-HYDROXYACETOPHENONE 5'-CHLORO-2'-HYDROXYACETOPHENONE,5-CHLORO-2-HYDROXYACETOPHENONE 2'-Hydroxyacetophenone 1-CARBOXYL-5,7-DIBROMO-6-HYDROXY-2,3,4-TRICHLOROXANTHONE 1-(4-CHLORO-2-HYDROXYPHENYL)PROPAN-1-ONE 7-CHLORO-3-FORMYLCHROMONE 7-CHLORO-2-PHENYL-4H-CHROMEN-4-ONE 7-CHLOROCHROMONE-3-SULFONYLCHLORIDE 7-chloro-4-oxo-4H-chromene-2-carboxylic acid

1-(4-CHLORO-2-HYDROXYPHENYL)ETHANONE

4'-CHLORO-2'-HYDROXYACETOPHENONE

4-CHLORO-2-HYDROXYACETOPHENONE

1-(4-Chloro-2-hydroxyphenyl)ethan-1-one

1-(4-Chloro-2-hydroxyphenyl)ethan-1-one, 2-Acetyl-5-chlorophenol

4-Chloro-2-hydroxyacetophenone,97%

4'-Chloro-2'-hydroxyacetophenone &gt

Ethanone, 1-(4-chloro-2-hydroxyphenyl)-

4'-Chloro-2'-hydroxycetophone

6921-66-0

6932-66-0

Adehydes, Acetals & Ketones

Chlorine Compounds

Aromatic Acetophenones & Derivatives (substituted)