ChemicalBook > CAS DataBase List > PD 98059

PD 98059

Product Name
PD 98059
CAS No.
167869-21-8
Chemical Name
PD 98059
Synonyms
2-(2-AMINO-3-METHOXYPHENYL)-4H-CHROMEN-4-ONE;CS-398;PD 98059;PD090859;PD 098,059;PD 98059 NEW;PD 98059, 99+%;Amino chromone;PD 98059, >=98%;PD-98059/PD98059
CBNumber
CB3256152
Molecular Formula
C16H13NO3
Formula Weight
267.28
MOL File
167869-21-8.mol
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PD 98059 Property

Melting point:
164～165℃
Boiling point:
453.1±45.0 °C(Predicted)
Density 
1.300±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
ethanol: 0.6 mg/mL
pka
1.21±0.10(Predicted)
form 
solid
color 
yellow
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChIKey
QFWCYNPOPKQOKV-UHFFFAOYSA-N
CAS DataBase Reference
167869-21-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
22-60-36
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
HS Code 
29322090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P330Rinse mouth.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P215
Product name
PD 98,059
Purity
solid
Packaging
1mg
Price
$78.6
Updated
2024/03/01
Sigma-Aldrich
Product number
513000
Product name
PD 98059 - CAS 167869-21-8 - Calbiochem
Packaging
5mg
Price
$159
Updated
2024/03/01
Sigma-Aldrich
Product number
513001
Product name
InSolution? PD 98059
Packaging
1ml
Price
$172
Updated
2024/03/01
Sigma-Aldrich
Product number
19-143
Product name
PD 98059
Packaging
5MG
Price
$188
Updated
2024/03/01
Alfa Aesar
Product number
J64485
Product name
2'-Amino-3'-methoxyflavone, 99%
Packaging
10mg
Price
$105.65
Updated
2024/03/01
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PD 98059 Chemical Properties,Usage,Production

Description

PD 98059 is a noncompetitive inhibitor of the MAPK pathway. It prevents the activation of MEK by Raf or MEK kinase (a MAP3K) with an IC50 value of 2-7 μM but does not inhibit Raf-activated MAP2K1. It inhibits Raf activation of MAP2K2 with an IC50 value of 50 μM. PD 98059 also phosphorylates and activates AMP-activated protein kinase (AMPK) in a dose-dependent manner (EC50 = 35 μM in HEK293 cells). It increases the ratios of ADP to ATP and AMP to ATP and increases phosphorylation of the AMPK target acetyl-CoA carboxylase (ACC).

Uses

PD 98059 is a selective inhibitor of MEK and blocker of MAPK.

Definition

ChEBI: A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'

General Description

Selective, reversible, and cell-permeable inhibitor of MAP kinase kinase (MEK) that acts by inhibiting the activation of MAP kinase and subsequent phosphorylation of MAP kinase substrates. Pretreatment of PC-12 cells with PD 98059 completely blocks the 4-fold increase in MAP kinase activity produced by nerve growth factor (NGF; IC50 = 2 μM); however, it has no effect on NGF-dependent tyrosine phosphorylation of the p140trk receptor or its substrate Shc and does not block NGF-dependent activation of PI 3-kinase. Blocks LPS-induced activation of TNF-α gene expression. Inhibits cell growth and reverses the phenotype of ras-transformed BALB3T3 mouse fibroblasts and rat kidney cells. A 5 mg/ml solution of PD 98059 (Cat. No. 513001) in anhydrous DMSO is also available.

Biological Activity

Specific inhibitor of mitogen-activated protein kinase kinase (MAPKK / MEK). Acts by binding to the inactivated form of MEK, thereby preventing its phosphorylation by cRAF or MEK kinase (IC 50 = 2-7 μ M). Inhibits cell growth and proliferation in acute myelogenous leukemia (AML) cell lines; causes G 1 arrest by blocking p53-dependent p21 induction. Also available as part of the MAPK Cascade Inhibitor Tocriset™ and MAPK Inhibitor Tocriset™ .

Biochem/physiol Actions

PD 98,059 is a flavonoid and specific inhibitor of mitogen-activated protein kinase kinase (MAPKK). In mice, PD 98,059 helps to block zymosan stimulated organ dysfunction syndrome and non-septic shock. It is known to inhibit in vitro hypertrophy. PD 98,059 also induces cartilage formation in mesenchymal stromal cells.

storage

Room temperature

References

1) Alessi et al. (1995), PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo; J. Biol. Chem., 270 27489 2) Dudley et al. (1995), A synthetic inhibitor of the mitogen-activated protein kinase cascade; Proc. Natl. Acad. Sci., 92 7686 3) Hotokezaka et al. (2002) U0126 and PD98059, specific inhibitors of MEK, accelerate differentiation of RAW264.7 cells into osteoclast-like cells; J. Biol. Chem., 277 47366 4) Xiaoxia et al. (2004) BMP4 supports self-renewal of embryonic stem cells by inhibiting mitogen-activated protein kinase pathways; Proc. Natl. Acad. Sci. USA 101 6027

PD 98059 Preparation Products And Raw materials

Raw materials

Preparation Products

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PD 98059 Suppliers

China 147 China Hong Kong 1 Europe 2 Germany 2 India 3 Japan 4 South Korea 1 Switzerland 3 United Kingdom 10 United States 39 Global 212
Absin Bioscience Inc.
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View Lastest Price from PD 98059 manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
2-(2-aMino-3-Methoxyphenyl)-4H-chroMen-4-one 167869-21-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27
Career Henan Chemical Co
Product
InSolution PD 98059 167869-21-8
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1lg; 2kg; 5kg; 10kg; 100kg
Release date
2019-08-31
Career Henan Chemical Co
Product
InSolution PD 98059 167869-21-8
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1lg; 2kg; 5kg; 10kg; 100kg
Release date
2019-08-31

167869-21-8, PD 98059Related Search:

PD153035 HCl PD 166285 PD173955 PD 0325901 PD 166793 PD184352 PD318088 1-(2-BROMOPHENYL)-2-THIOUREA 3'-Amino-4'-methoxyacetanilide p-Anisidine-3-sulfonic acid U0126-EtOH WORTMANNIN 1,9-Pyrazoloanthrone SB 203580 LY 294002 HYDROCHLORIDE Rapamycin PD158780 3-METHOXYFLAVONE

  • 2-(2-AMINO-3-METHOXYPHENYL)-4H-1-BENZOPYRAN-4-ONE
  • 2-(2-AMINO-3-METHOXY-PHENYL)CHROMEN-4-ONE
  • 2'-AMINO-3'-METHOXYFLAVONE
  • PD 98059 in Solution
  • PD 98059
  • PD 098,059
  • 2-(2-AMINO-3-METHOXYPHENYL)-4H-CHROMEN-4-ONE
  • PD 098,059 (2-(2-AMINO-3-METHOXYPHENYL)- 4H-1-BENZOPYRAN-4-ONE
  • PD 98059, 99+%
  • 4H-1-Benzopyran-4-one, 2-(2-amino-3-methoxyphenyl)-
  • 4H-1-Benzopyran-4-one,2-(2-amino-3-methoxyphenyl)-(9CI)
  • PD090859
  • PD-98059/PD98059
  • 2-(2-AMino-3-Methoxyphenyl)chroMone
  • 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one PD 98059
  • PD 98059 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one
  • PD 98059, >=98%
  • InSolution? PD 98059
  • 2-(2-Amino-3-methoxy-phenyl)chromen-4-one, 98%, a non-ATP competitive MEK inhibitor
  • PD 98059 NEW
  • CS-398
  • PD 98059 - NSC 679828
  • InSolution PD 98059 - CAS 167869-21-8 - Calbiochem
  • PD 98059 - CAS 167869-21-8 - Calbiochem
  • Amino chromone
  • 2-(2-Amino-3-methoxyphenyl)chromone &gt
  • PD 98059 USP/EP/BP
  • PD 98059 (DMSO solution)
  • 167869-21-8
  • C16H13O3N
  • Specific inhibitor of the activation of mitogen-activated protein kinase kinase
  • Mitogen-Activated Protein Kinase Kinase (MAPKK)
  • Kinase/Phosphatase Biology
  • Serine/Threonine Kinase Inhibitors
  • BioChemical
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Inhibitors
  • inhibitor
  • MAPK
  • Signalling
  • pharmacetical
  • Protein Kinase
  • FLAVONE