ChemicalBook > CAS DataBase List > Isosorbide 5-mononitrate

Isosorbide 5-mononitrate

Product Name
Isosorbide 5-mononitrate
CAS No.
16051-77-7
Chemical Name
Isosorbide 5-mononitrate
Synonyms
ISOSORBIDE MONONITRATE;ISMN;Ismo;IMDUR;5-ismn;Vasotrate;5-ISOSORBIDE MONONITRATE;ELAN;Momt;Coronu
CBNumber
CB3256697
Molecular Formula
C6H9NO6
Formula Weight
191.14
MOL File
16051-77-7.mol
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Isosorbide 5-mononitrate Property

Melting point:
88-93 °C
alpha 
170 º (c=1, EtOH)
Boiling point:
326.86°C (rough estimate)
Density 
1.5784 (rough estimate)
refractive index 
145 ° (C=5, H2O)
storage temp. 
-20°C Freezer
solubility 
Undiluted isosorbide mononitrate is freely soluble in water, in acetone, in ethanol (96 per cent) and in methylene chloride. The solubility of the diluted product depends on the diluent and its concentration.
pka
13.09±0.40(Predicted)
form 
Solid
color 
White to Off-White
Water Solubility 
soluble
Merck 
5225
InChIKey
YWXYYJSYQOXTPL-SLPGGIOYSA-N
CAS DataBase Reference
16051-77-7(CAS DataBase Reference)
EPA Substance Registry System
D-Glucitol, 1,4:3,6-dianhydro-, 5-nitrate (16051-77-7)
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Safety

Hazard Codes 
Xi-F,Xi,F
Risk Statements 
36/37/38-11
Safety Statements 
37/39-16-15
RIDADR 
3251
RTECS 
LZ4386500
HazardClass 
4.1
HS Code 
2932999000
Toxicity
LD50 oral in rat: 2010mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H228Flammable solid

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P370+P378In case of fire: Use … for extinction.

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N-Bromosuccinimide Price

Alfa Aesar
Product number
J63674
Product name
Isosorbide mononitrate, 98+%
Packaging
5g
Price
$193.65
Updated
2024/03/01
Alfa Aesar
Product number
J63674
Product name
Isosorbide mononitrate, 98+%
Packaging
10g
Price
$307.65
Updated
2024/03/01
Alfa Aesar
Product number
J63674
Product name
Isosorbide mononitrate, 98+%
Packaging
25g
Price
$704.65
Updated
2024/03/01
TRC
Product number
KIT8290
Product name
Isosorbide5-Mononitrate(1.0mg/mLinDimethylSulfoxide)
Packaging
10x1mL
Price
$180
Updated
2021/12/16
Apolloscientific
Product number
BICL4113
Product name
Isosorbide-5-mononitrate
Purity
99%min
Packaging
500mg
Price
$707
Updated
2021/12/16
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Isosorbide 5-mononitrate Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powde

Uses

antidepressant, 5HT reuptake inhibitor

Uses

Isosorbide 5-Mononitrate is a metabolite of Isosorbide Dinitrate; used as an antianginal.

Uses

A metabolite of Isosorbide Dinitrate. Used as an antianginal

Definition

ChEBI: Isosorbide mononitrate is a nitrate ester and a glucitol derivative. It has a role as a nitric oxide donor and a vasodilator agent.

brand name

Imdur (Schering-Plough); Ismo (Dr. Reddy’s); Monoket (Schwarz Pharma) .

General Description

Isosorbide 5-mononitrate is a crystalline solid. Isosorbide 5-mononitrate is very flammable and may be toxic by ingestion.

Air & Water Reactions

Highly flammable.

Reactivity Profile

The dinitrate, a heart drug, can detonate when dry, but is non explosive with 30% of water [J. Haz.. Mater., 1992, 32(1), 87]. The mononitrate would be expected to be less reactive.

Health Hazard

Fire may produce irritating and/or toxic gases. Contact may cause burns to skin and eyes. Contact with molten substance may cause severe burns to skin and eyes. Runoff from fire control may cause pollution.

Fire Hazard

Flammable/combustible material. May be ignited by friction, heat, sparks or flames. Some may burn rapidly with flare burning effect. Powders, dusts, shavings, borings, turnings or cuttings may explode or burn with explosive violence. Substance may be transported in a molten form at a temperature that may be above its flash point. May re-ignite after fire is extinguished.

Clinical Use

Vasodilator:
Treatment and prophylaxis of angina
Adjunct in congestive heart failure

Isosorbide 5-mononitrate Preparation Products And Raw materials

Raw materials

D-Sorbitol Isosorbide dinitrate Sorbitol

Preparation Products

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View Lastest Price from Isosorbide 5-mononitrate manufacturers

Hebei Mujin Biotechnology Co.,Ltd
Product
Isosorbide 5-Mononitrate 16051-77-7
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-09-07
Hebei Zhuanglai Chemical Trading Co Ltd
Product
Isosorbide 5-Mononitrate 16051-77-7
Price
US $50.00/kg
Min. Order
1kg
Purity
99
Supply Ability
5000
Release date
2024-12-10
Hebei Weibang Biotechnology Co., Ltd
Product
Isosorbide 5-Mononitrate 16051-77-7
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10 mt
Release date
2024-11-06

16051-77-7, Isosorbide 5-mononitrateRelated Search:

Isosorbide Isosorbide dinitrate ISOSORBIDE 2-MONONITRATE,ISOSORBIDE 2-MONONITRATE 99-101.0% Sodium hydride NIVITIN DEHYDROGENASE Sorbitol Prenyl acetate isosorbide-5-mononitrate-2-glucuronide ISOSORBIDE-13C6 DINITRATE Isosorbide 5-mononitrate

  • IMDUR
  • IS-5-MN
  • ISOSORBIDE MONONITRATE
  • ISOSORBIDE 5-MONONITRATE
  • ISOSORBIDE 5-NITRATE
  • ELANTAN
  • ELAN
  • CORANGIN
  • 5-ISOSORBIDE MONONITRATE
  • MONOSORB
  • MONOCEDOCARD
  • MONOCLAIR
  • 1,4:3,6-dianhydro-,5-nitrate,d-glucito
  • 1,4:3,6-dianhydro-d-glucito5-nitrate
  • 1,4:3,6-dianhydro-d-glucitol5-nitrate
  • 1,4:3,6-DIANHYDRO-D-GLUCITOL 5-MONONITRATE
  • 6-Nitrooxy-hexahydro-furo[3,2-β]furan-3-ol
  • 6-Nitrooxy-hexahydro-furo[3,2-b]furan-3-ol
  • D-Glucitol, 1,4:3,6-dianhydro-, 5-nitrate
  • [(1R,2R,5R,6S)-6-hydroxy-4,8-dioxabicyclo[3.3.0]oct-2-yl] nitrate
  • ISOSORBIDE MONO ACETATE
  • 5-ismn
  • ahr4698
  • bm22-145
  • Ososoribide-5-mononitrate
  • ISOSORBIDE 5-MONONITRATE, 98.5%
  • Corangin,Elan,Elantan,Imdur,Monocedocard,Monoclair,Monosorb
  • 1,4:3,6-Dianhydro-D-glucitol mononitrate
  • 1,4:3,6-Dianhydro-D-glucitd 5-mononitrate
  • Vasotrate
  • ISOSORBIDE MONONITRATE(ISOSORBIDE-5-MONONITRATE)
  • isosorbide 5-mononitrite
  • Erlotinib-d17 HCl
  • Diluted Isosorbide Mononitrate (50%)
  • 1,4:3,6-Dianhydro-5-O-nitro-D-erythro-hexitol
  • IS-5-MN (ISOSORBIDE-5-MONONITRATE
  • (3S,3aS,6R,6aR)-6-hydroxyhexahydrofuro[3,2-b]furan-3-yl nitrate
  • Isosorbide-5-mononitrate min. 99%
  • Isosorbide Mononitrate EP
  • Coronu
  • Ismo
  • Isomonat
  • Momt
  • Monicor
  • Olicard
  • [(3R,3aS,6S,6aR)-6-hydroxy-2,3,3a,5,6,6a-hexahydrofuro[2,3-d]furan-3-yl nitrate
  • 5-Nitro-1,4,3,6-dianhydro-D-glucitol
  • 6-Nitroxoyhexahydrofuro[3,2-b]furan-3-ol
  • 8-Nitrooxy-2,6-dioxabicyclo[3.3.0]octan-4-ol
  • ISMN
  • TY-10368
  • Isosorbide mononitrate,contains ~30%(w/w) lactose
  • (3R,3aS,6S,6aR)-6-hydroxyhexahydrofuro[3,2-b]furan-3-yl nitrate
  • Diluted Isosorbide Mononitrate (750 mg)
  • Isosorbide 5-Mononitrate (1.0 mg/mL in Dimethyl Sulfoxide)
  • Isosorbide5-Nitrate&gt
  • Isosorbide mononitrate CRS
  • Monoket