LB 42708

Product Name: LB 42708
CAS No.: 226929-39-1
Chemical Name: LB 42708
Synonyms: CS-1450;LB 42708;LB-42708;LB 42708;LB 42708 USP/EP/BP;[1-{[1-(4-bromobenzyl)-1h-imidazol-5-yl]methyl}-4-(1-naphthyl)-1h -pyrrol-3-yl](4-morpholinyl)methanone;4-[[1-[[1-[(4-Bromophenyl)methyl]-1H-imidazol-5-yl]methyl]-4-(1-naphthalenyl)-1H-pyrrol-3-yl]carbonyl]morpholine;[1-[[1-[(4-Bromophenyl)methyl]-1H-imidazol-5-yl]methyl]-4-(1-naphthalenyl)-1H-pyrrol-3-yl]-4-morpholinylmethanone;Methanone, [1-[[1-[(4-bromophenyl)methyl]-1H-imidazol-5-yl]methyl]-4-(1-naphthalenyl)-1H-pyrrol-3-yl]-4-morpholinyl-;[1-[[1-[(4-Bromophenyl)methyl]-1H-imidazol-5-yl]methyl]-4-(1-naphthalenyl)-1H-pyrrol-3-yl]-4-morpholinylmethanone LB42708
CBNumber: CB32569683
Molecular Formula: C30H27BrN4O2
Formula Weight: 555.47
MOL File: 226929-39-1.mol

More

Less

LB 42708 Property

Boiling point:: 769.6±60.0 °C(Predicted)
Density: 1.39±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≥22.75 mg/mL in DMSO; insoluble in H2O; ≥47.5 mg/mL in EtOH
form: solid
pka: 5.67±0.13(Predicted)
color: Off-white to light yellow

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 16428
Product name: LB 42708
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 16428
Product name: LB 42708
Purity: ≥98%
Packaging: 5mg
Price: $118
Updated: 2024/03/01

Cayman Chemical

Product number: 16428
Product name: LB 42708
Purity: ≥98%
Packaging: 10mg
Price: $193
Updated: 2024/03/01

Usbiological

Product number: 453580
Product name: LB 42708
Packaging: 1mg
Price: $312
Updated: 2021/12/16

Usbiological

Product number: 255665
Product name: LB 42708
Packaging: 10mg
Price: $489
Updated: 2021/12/16

More

Less

LB 42708 Chemical Properties,Usage,Production

Uses

LB 42708 is a selective nonpeptidic Farnesyltransferase (FTase) inhibitor.LB42708 suppresses tumor growth and tumor angiogenesis in both xenograft tumor models of Ras-mutated HCT116 cells and its wild-type Caco-2 cells, indicating its potential application in the treatment of both Ras-mutated and wild type tumors.

Biological Activity

lb42708 is a selective inhibitor of farnesyltransferase (ftase) with ic50 value of 0.8nm [1].lb42708 is a nonpeptide pyrrole-based ftase inhibitor with high potency and selectivity. it inhibits the farnesylation of h-ras, n-ras and k-ras4b in vitro with ic50 values of 0.8nm, 1.2nm and 2nm, respectively. to the related enzyme geranylgeranyltransferase i, lb42708 shows no significant inhibition with ic50 value of 100μm. in cultured raw264.7 cell line, lb42708 potently reduces the farnesylated p21ras stimulated by lps and ifn-γ with ic50 value of ~ 10nm. besides that, the huvec cells treated with lb42708 shows inhibition of cell proliferation and migration induced by vegf. lb42708 inhibits the vegf-induced dna synthesis with ic50 value of 75nm and also inhibits vegf-induced formation of the gtp-bound form of ras with ic50 values of 50nm. in addition, it affects the tube-like structure formation. furthermore, the administration of lb42708 can suppress tumor growth both in ras-mutated hct116 and wild-type caco-2 xenograft models [1, 2].

References

[1] na h j, lee s j, kang y c, et al. inhibition of farnesyltransferase prevents collagen-induced arthritis by down-regulation of inflammatory gene expression through suppression of p21ras-dependent nf-κb activation. the journal of immunology, 2004, 173(2): 1276-1283.
[2] kim c k, choi y k, lee h, et al. the farnesyltransferase inhibitor lb42708 suppresses vascular endothelial growth factor-induced angiogenesis by inhibiting ras-dependent mitogen-activated protein kinase and phosphatidylinositol 3-kinase/akt signal pathways. molecular pharmacology, 2010, 78(1): 142-150.

LB 42708 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

LB 42708 Suppliers

China 68 India 1 The Netherlands 1 United Kingdom 2 United States 10 Global 82

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
ProdList: 2559
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32165
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

ApexBio Technology

Tel: --
Fax: --
Email: sales@apexbt.com
Country: United States
ProdList: 6251
Advantage: 58

Cayman Chemical Company

Tel: --
Fax: --
Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

United States Biological

Tel: --
Fax: --
Email: chemicals@usbio.net
Country: United States
ProdList: 6214
Advantage: 80

Axon Medchem LLC

Tel: --
Fax: --
Email: info@axonmedchem.com
Country: United States
ProdList: 763
Advantage: 58

226929-39-1, LB 42708Related Search:

DNA, SINGLE STRANDED, IMM. ON CELLULOSE, FROM CALF THYMUS* WZ4003 ABT 737 VE 822 LONAFARNIB K-Ras(G12C) inhibitor 6 AZD5363

LB 42708

[1-[[1-[(4-Bromophenyl)methyl]-1H-imidazol-5-yl]methyl]-4-(1-naphthalenyl)-1H-pyrrol-3-yl]-4-morpholinylmethanone

[1-[[1-[(4-Bromophenyl)methyl]-1H-imidazol-5-yl]methyl]-4-(1-naphthalenyl)-1H-pyrrol-3-yl]-4-morpholinylmethanone LB42708

4-[[1-[[1-[(4-Bromophenyl)methyl]-1H-imidazol-5-yl]methyl]-4-(1-naphthalenyl)-1H-pyrrol-3-yl]carbonyl]morpholine

[1-{[1-(4-bromobenzyl)-1h-imidazol-5-yl]methyl}-4-(1-naphthyl)-1h -pyrrol-3-yl](4-morpholinyl)methanone

LB-42708;LB 42708

CS-1450

Methanone, [1-[[1-[(4-bromophenyl)methyl]-1H-imidazol-5-yl]methyl]-4-(1-naphthalenyl)-1H-pyrrol-3-yl]-4-morpholinyl-

LB 42708 USP/EP/BP

226929-39-1

Inhibitors