Tubastatin A hydrochloride

Product Name: Tubastatin A hydrochloride
CAS No.: 1310693-92-5
Chemical Name: Tubastatin A hydrochloride
Synonyms: TSA HCl;CS-1894;Tubastatin A HCl salt;Tubastatin A HCl, >=98%;Tubastatin A hydrochloride;TUBASTATIN A HYDROCHLORIDE;TSA HCL;Tubastatin A HCl (AG-CR-13900, TubA);Tubastatin A hydrochloride ISO 9001：2015 REACH;Tubastatin A Hydrochloride (Also See: T897000);Tubastatin A HCl, 98%, a potent and selective HDAC6 inhibitor
CBNumber: CB32589694
Molecular Formula: C20H22ClN3O2
Formula Weight: 371.87
MOL File: 1310693-92-5.mol

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Tubastatin A hydrochloride Property

Melting point:: >221°C (subl.)
storage temp.: -20°C
solubility: Soluble in DMSO or Water.
form: powder
color: white to tan
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.

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Safety

WGK Germany: 3
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0044
Product name: Tubastatin A hydrochloride
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $210
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0044
Product name: Tubastatin A hydrochloride
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $805
Updated: 2024/03/01

TCI Chemical

Product number: T3687
Product name: Tubastatin A Hydrochloride
Packaging: 25MG
Price: $190
Updated: 2024/03/01

TCI Chemical

Product number: T3687
Product name: Tubastatin A Hydrochloride
Packaging: 100MG
Price: $580
Updated: 2024/03/01

Tocris

Product number: 6270
Product name: Tubastatin A hydrochloride
Purity: ≥98%(HPLC)
Packaging: 10
Price: $126
Updated: 2021/12/16

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Tubastatin A hydrochloride Chemical Properties,Usage,Production

Description

Tubastatin A (1310693-92-5) is a potent and highly selective inhibitor of HDAC6 (IC50?= 15 nM, >1000-fold selectivity against other HDAC isoforms, approx. 60-fold versus HDAC8).1?It displayed anti-inflammatory and anti-rheumatic effects in Freund’s competitive adjuvant induced animal model of inflammation.2?Tubastatin A inhibited TNF-α (IC50?= 272 nM) and IL-6 (IC50 = 712 nM) in LPS stimulated human THP-1 macrophages.2?Tubastatin A has also been shown to have therapeutic potential for treatment of Alzheimer’s disease via altered amyloid-β load and reduced tau hyperphosphorylation.3-5

Uses

Tubastatin A Hydrochloride is an LSD1 inhibitor, which targets SOX2-expressing cancer cells.

Uses

Tubastatin A Hydrochloride is a neuroprotective HDAC6 inhibitor and is also known to induce hyperacetylation in primary cortical neuron cultures.

Biochem/physiol Actions

Tubastatin A increases the total numbers of mitochondria and restores the number of moving mitochondria in DRG neurons. It reverses the axonal loss in peripheral neurons in mouse model of Charcot-Marie-Tooth disease. Tubastatin A inhibits the deacetylation of α-tubulin in murine myoblasts.

target

HDAC6

storage

Store at -20°C

References

1) Butler?et al. (2010),?Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A; J. Am. Chem. Soc.,?132?10842 2) Vishwakarma?et al. (2013),?Tubastatin, a selective histone deacetylase 6 inhibitor shows anti-inflammatory and anti-rheumatic effects; Int. Immunopharmacol.,?16?72 3) Noack and Richter-Landsberg (2014),?HDAC6 inhibition results in tau acetylation and modulates tau phosphorylation and degradation in oligodendrocytes; Glia,?62?535 4) Selenica?et al. (2014),?Histone deacetylase 6 inhibition improves memory and reduces total tau levels in a mouse model of tau deposition; Alzheimers Res.Ther.,?6?12 5) Zhang?et al. (2014)?Tubastatin A/ACY-1215 improves cognition in Alzheimer’s disease transgenic mice; J. Alzheimers Dis.,?41?1193

Tubastatin A hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Tubastatin A hydrochloride Suppliers

Canada 1 China 95 India 3 Japan 1 United Kingdom 2 United States 21 Global 123

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View Lastest Price from Tubastatin A hydrochloride manufacturers

Dideu Industries Group Limited

Product: Tubastatin A hydrochloride 1310693-92-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-09-28

Career Henan Chemical Co

Product: Tubastatin A HCl 1310693-92-5
Price: US $1.00/KG
Min. Order: 1g
Purity: Min98% HPLC
Supply Ability: g/kg /ton
Release date: 2019-12-20

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1310693-92-5

C20H21N3O2HCl

Inhibitors