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SB1317

Product Name
SB1317
CAS No.
937270-47-8
Chemical Name
SB1317
Synonyms
CS-915;TG02;TG-02;(E/Z)-TG02;(E/Z)-SB1317;SB1317, >=98%;TG-02/SB-1317;(E/Z)-Zotiraciclib;Zotiraciclib free base;Zotiraciclib (SB1317) HCl;SB1317(TG-02) hydrochloride
CBNumber
CB32628476
Molecular Formula
C23H24N4O
Formula Weight
372.46
MOL File
937270-47-8.mol
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SB1317 Property

Boiling point:
575.5±60.0 °C(Predicted)
Density 
1.16±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
insoluble in H2O; ≥44.87 mg/mL in DMSO; ≥3.98 mg/mL in EtOH with gentle warming and ultrasonic
form 
solid
pka
8.03±0.20(Predicted)
color 
Off-white to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
T337705
Product name
TG02
Packaging
5mg
Price
$140
Updated
2021/12/16
Biosynth Carbosynth
Product number
BS167349
Product name
SB 1317
Packaging
10mg
Price
$125
Updated
2021/12/16
Biosynth Carbosynth
Product number
BS167349
Product name
SB 1317
Packaging
25mg
Price
$150
Updated
2021/12/16
AK Scientific
Product number
4029AH
Product name
14-Methyl-20-oxa-5,7,14,27-tetraazatetracyclo[19.3.1.12,6.18,12]heptacosa-1(25),2,4,6(27),8,10,12(26),16,21,23-decaene
Packaging
10mg
Price
$178
Updated
2021/12/16
Biosynth Carbosynth
Product number
BS167349
Product name
SB 1317
Packaging
100mg
Price
$375
Updated
2021/12/16
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SB1317 Chemical Properties,Usage,Production

Uses

TG 02 is a cyclin dependent kinase inhibitors (CDK inhibitors) for the treatment of chronic lymphocytic leukemia.

in vivo

(E/Z)-Zotiraciclib (50 and 75 mg/kg; p.o. once daily for 3 weeks) inhibits tumor growth[1].? (E/Z)-Zotiraciclib (15 and 75 mg/kg; p.o. once daily 2 days on and 5 days off; i.p. once daily 5 days on 5 days off) inhibits tumor growth in two manners[1].

Animal Model:Male BALB/c mice with HCT-116 colon cancer cells xenografts[1]
Dosage:50 and 75 mg/kg
Administration:Oral gavage; 50 and 75 mg/kg once daily for 3 weeks
Result:Significantly inhibited the growth of tumors with a mean TGI of 82%.
Animal Model:Male BALB/c mice with lymphoma Ramos cells xenografts[1]
Dosage:15 and 75 mg/kg
Administration:Oral gavage and intraperitoneal injection ; 75 mg/kg once daily 2 days on and 5 days off (p.o.) and 15 mg/kg once daily 5 days on 5 days off (i.p.)
Result:Significantly inhibited the growth of tumors with mean TGIs of 42% and 63% for the oral and ip delivery methods, respectively.

IC 50

CDK2: 13 nM (IC50); JAK2: 73 nM (IC50); FLT3: 56 nM (IC50)

SB1317 Preparation Products And Raw materials

Raw materials

Preparation Products

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SB1317 Suppliers

China 72 United Kingdom 1 United States 10 Global 83
Carbosynth
Tel
--
Fax
--
Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6005
Advantage
58

937270-47-8, SB1317Related Search:

SB-649868 SB 204741 SB1317 SB216763 Sb-742457 MMP-2/MMP-9 INHIBITOR IV SB 242084 (hydrochloride) SB 415286 SB 202190 SB 431542 5-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime SB 269970 HYDROCHLORIDE 6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline 4'-CHLORO-3-METHOXYCINNAMANILIDE SB-705498 SB 203580 SB242235 2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrate hydrochloride

  • TG-02/SB-1317
  • 14-Methyl-20-oxa-5,7,14,27-tetraazatetracyclo[19.3.1.12,6.18,12]heptacosa-1(25),2,4,6(27),8,10,12(26),16,21,23-decaene
  • SB1317, >=98%
  • SB1317(TG-02) hydrochloride
  • CS-915
  • TG02; SB 1317; TG 02; SB-1317; TG-02
  • TG02;TG-02
  • 20-Oxa-5,7,14,27-tetraazatetracyclo[19.3.1.12,6.18,12]heptacosa-1(25),2,4,6(27),8,10,12(26),16,21,23-decaene, 14-methyl-
  • (E/Z)-SB1317
  • (E/Z)-TG02
  • (E/Z)-Zotiraciclib
  • Zotiraciclib free base
  • Zotiraciclib (SB1317) HCl
  • multiple myeloma,JAK2,Fms like tyrosine kinase 3,Cyclin dependent kinase,JAK,FLT3,Janus kinase,CD135,leukemias,Inhibitor,CDK,CDK2,Cluster of differentiation antigen 135,inhibit,cancer,(E/Z)-Zotiraciclib,(E/Z) Zotiraciclib,(E/Z)Zotiraciclib
  • 6-Methyl-12-oxa-3,6-diaza-2(4,2)-pyrimidina-1,4(1,3)-dibenzenacyclododecaphan-8-ene
  • (E/Z)-Zotiraciclib, 10 mM in DMSO
  • (E/Z)-Zotiraciclib ((E/Z)-TG-02, (E/Z)-SB1317)
  • (e)-6-methyl-12-oxa-3,6-diaza-2(4,2)-pyrimidina-1,4(1,3)-dibenzenacyclododecaphan-8-ene
  • 937270-47-8