AZ20

Product Name: AZ20
CAS No.: 1233339-22-4
Chemical Name: AZ20
Synonyms: AZ20;CS-1335;AZ-20; AZ 20;;AZ20 USP/EP/BP;1H-Indole, 4-[4-[(3R)-3-methyl-4-morpholinyl]-6-[1-(methylsulfonyl)cyclopropyl]-2-pyr;(3R)-4-[2-(3H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]-3-methylmorpholine;(R)-4-(2-(1H-Indol-4-yl)-6-(1-(methylsulfonyl)cyclopropyl)pyrimidin-4-yl)-3-methylmorpholine;4-[4-(1-Methanesulfonylcyclopropyl)-6-[(3R)-3-methylmorpholin-4-yl]pyrimidin-2-yl]-1H-indole;4-[4-[(3R)-3-Methyl-4-morpholinyl]-6-[1-(methylsulfonyl)cyclopropyl]-2-pyrimidinyl]-1H-indole;1H-Indole, 4-[4-[(3R)-3-methyl-4-morpholinyl]-6-[1-(methylsulfonyl)cyclopropyl]-2-pyrimidinyl]-
CBNumber: CB32655393
Molecular Formula: C21H24N4O3S
Formula Weight: 412.51
MOL File: 1233339-22-4.mol

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AZ20 Property

Boiling point:: 634.6±55.0 °C(Predicted)
Density: 1.42±0.1 g/cm3(Predicted)
storage temp.: -20°
solubility: Soluble in DMSO (up to 20 mg/ml).
form: solid
pka: 15.65±0.30(Predicted)
color: Off-white
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 17589
Product name: AZ 20
Purity: ≥98%
Packaging: 1mg
Price: $26
Updated: 2024/03/01

Cayman Chemical

Product number: 17589
Product name: AZ 20
Purity: ≥98%
Packaging: 5mg
Price: $58
Updated: 2024/03/01

Cayman Chemical

Product number: 17589
Product name: AZ 20
Purity: ≥98%
Packaging: 10mg
Price: $102
Updated: 2024/03/01

Cayman Chemical

Product number: 17589
Product name: AZ 20
Purity: ≥98%
Packaging: 25mg
Price: $625
Updated: 2023/06/20

Tocris

Product number: 5198
Product name: AZ20
Purity: ≥98%(HPLC)
Packaging: 10
Price: $290
Updated: 2021/12/16

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AZ20 Chemical Properties,Usage,Production

Description

AZ20 (1233339-22-4) is a potent and highly selective inhibitor of Ataxia telangiectasia mutated and RAD3-related (ATR) kinase (IC50?= 5 nM in vitro; IC50?= 50 nM in HT29 colorectal adenocarcinoma cells).1?Combination therapy with AZ20 and gemcitabine resulted in synergistic inhibition of tumor cell growth and cell death initiation in pancreatic cancer cell lines.2

Uses

AZ20 is a potent and selective inhibitor of ATR (ATM-Rad3-related) kinase with in vivo antitumor activity.

Definition

ChEBI: (3R)-4-[2-(1H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)-4-pyrimidinyl]-3-methylmorpholine is a member of indoles.

storage

Store at -20°C

References

1) Foote?et al.?(2013)?Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): A Potent and Selective Inhibitor of ATR Protein Kinase with Monotherapy In Vivo Antitumor Activity; J. Med. Chem.?56?2125 2) Liu?et al.?(2017)?Inhibition of ATR potentiates the cytotoxic effect of gemcitabine on pancreatic cancer cell lines through enhancement of DNA damage and abrogation of ribonucleotide reductase induction by gemcitabine; Oncol. Rep.?37?3377

AZ20 Preparation Products And Raw materials

Raw materials

Preparation Products

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AZ20 Suppliers

China 96 France 1 India 2 The Netherlands 1 United Kingdom 3 United States 16 Global 119

AdooQ BioScience, LLC

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BOC Sciences

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Target molecule Corp.

Tel: 857-239-0968
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Musechem

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TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
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InvivoChem

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Fax: 708-557-7486
Email: sales@invivochem.cn
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Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
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Aladdin Scientific

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Focus Biomolecules

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Cayman Chemical Company

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United States Biological

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Axon Medchem LLC

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View Lastest Price from AZ20 manufacturers

Career Henan Chemical Co

Product: AZ20 1233339-22-4
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-23

1233339-22-4, AZ20Related Search:

NOTUMib-1 Pomalidomide Dequalinium chloride Imiquimod MK-2206 2HCl WORTMANNIN VE-821 KU-60019 VE 822 Olaparib

AZ-20; AZ 20;

CS-1335

AZ20

1H-Indole, 4-[4-[(3R)-3-methyl-4-morpholinyl]-6-[1-(methylsulfonyl)cyclopropyl]-2-pyrimidinyl]-

4-[4-[(3R)-3-Methyl-4-morpholinyl]-6-[1-(methylsulfonyl)cyclopropyl]-2-pyrimidinyl]-1H-indole AZ20

AZ20 4-[4-[(3R)-3-Methyl-4-morpholinyl]-6-[1-(methylsulfonyl)cyclopropyl]-2-pyrimidinyl]-1H-indole

4-[4-[(3R)-3-Methyl-4-morpholinyl]-6-[1-(methylsulfonyl)cyclopropyl]-2-pyrimidinyl]-1H-indole

(3R)-4-[2-(3H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]-3-methylmorpholine

4-[4-(1-Methanesulfonylcyclopropyl)-6-[(3R)-3-methylmorpholin-4-yl]pyrimidin-2-yl]-1H-indole

AZ20 USP/EP/BP

(R)-4-(2-(1H-Indol-4-yl)-6-(1-(methylsulfonyl)cyclopropyl)pyrimidin-4-yl)-3-methylmorpholine

1H-Indole, 4-[4-[(3R)-3-methyl-4-morpholinyl]-6-[1-(methylsulfonyl)cyclopropyl]-2-pyr

1233339-22-4

Inhibitors