PST2744 (hydrochloride)

Product Name: PST2744 (hydrochloride)
CAS No.: 374559-48-5
Chemical Name: PST2744 (hydrochloride)
Synonyms: PST2774;PST-2774;PST2744 (hydrochloride);PST-2744 (hydrochloride);PST 2744 (hydrochloride);IstaroxiMe (hydrochloride);Istaroxime hydrochloride, >=98%;Istaroxime hydrochloride(PST2744);(5alpha)-Androstane-3,6,17-trione 3-[O-(2-aminoethyl)oxime] monohydrochloride
CBNumber: CB32666641
Molecular Formula: C21H33ClN2O3
Formula Weight: 396.96
MOL File: 374559-48-5.mol

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PST2744 (hydrochloride) Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Powder
color: White to light brown

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-1623
Product name: Istaroxime(hydrochloride)
Purity: 99.32%
Packaging: 5mg
Price: $278
Updated: 2021/12/16

ApexBio Technology

Product number: A3508
Product name: Istaroximehydrochloride
Packaging: 5mg
Price: $340
Updated: 2021/12/16

ChemScene

Product number: CS-1623
Product name: Istaroxime(hydrochloride)
Purity: 99.32%
Packaging: 10mg
Price: $426
Updated: 2021/12/16

ApexBio Technology

Product number: A3508
Product name: Istaroximehydrochloride
Packaging: 10mg
Price: $520
Updated: 2021/12/16

ApexBio Technology

Product number: A3508
Product name: Istaroximehydrochloride
Packaging: 2mg
Price: $227
Updated: 2021/12/16

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PST2744 (hydrochloride) Chemical Properties,Usage,Production

Biological Activity

istaroxime hydrochloride(pst2744) is a novel inhibitor of na+/k+-atpase with ic50 value of 0.43±0.15μm [1].istaroxime is a steroidal drug unrelated to cardiac glycosides that improves cellular calcium cycling. the inhibition of na+/k+-atpase induces cytosolic calcium accumulation during systole (inotropism). clinical studies has been done with istaroxime in phase ii. istaroxime could be a promising alternative for patients with acute heart failure syndrome for whom the therapeutic options are currently limited [2].

in vitro

studies show that istaroxime can inhibit the activity of na+/k+-atpase from dog kidney without significant interaction with other several receptors. it demonstrates the selectivity of istaroxime. ex vivo studies show the inotropic effect can be achieved up to 60% for istaroxime. istaroxime can also increase the force of contraction of guinea pig paced left atria in the range 0.3 to 30μm. in vivo assays prove istaroxime is consistently safer than digoxin [1].

target

Na+/K+ ATPase

References

[1] r. micheletti, g. g. mattera, m. rocchetti, a. schiavone, m. f. loi, a. zaza, r. j. p. gagnol, s. de munari, p. melloni, p. carminati, g. bianchi, and p. ferrari. pharmacological profile of the novel inotropic agent (e,z)-3-((2-aminoethoxy)imino)androstane-6,17-dione hydrochloride (pst2744). the journal of pharmacology and experimental therapeutics. 2002, 303 (2): 592-600.
[2] suruchi aditya, aditya rattan. istaroxime: a rising star in acute heart failure. journal of pharmacology and pharmacotherapeutics. 2012, 3(4): 353-355.

PST2744 (hydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

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PST2744 (hydrochloride) Suppliers

China 23 United States 7 Global 30

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View Lastest Price from PST2744 (hydrochloride) manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Istaroxime hydrochloride 374559-48-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Istaroxime hydrochloride 374559-48-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

374559-48-5, PST2744 (hydrochloride)Related Search:

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374559-48-5

C21H32N2O3HCl