PST2744 (hydrochloride)

Product Name: PST2744 (hydrochloride)
CAS No.: 374559-48-5
Chemical Name: PST2744 (hydrochloride)
Synonyms: PST2774;PST-2774;PST2744 (hydrochloride);PST-2744 (hydrochloride);PST 2744 (hydrochloride);IstaroxiMe (hydrochloride);Istaroxime hydrochloride, >=98%;Istaroxime hydrochloride(PST2744);(5alpha)-Androstane-3,6,17-trione 3-[O-(2-aminoethyl)oxime] monohydrochloride
CBNumber: CB32666641
Molecular Formula: C21H33ClN2O3
Formula Weight: 396.96
MOL File: 374559-48-5.mol

More

Less

PST2744 (hydrochloride) Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Powder
color: White to light brown

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

ApexBio Technology

Product number: A3508
Product name: Istaroximehydrochloride
Packaging: 2mg
Price: $227
Updated: 2021/12/16

ChemScene

Product number: CS-1623
Product name: Istaroxime(hydrochloride)
Purity: 99.32%
Packaging: 5mg
Price: $278
Updated: 2021/12/16

ApexBio Technology

Product number: A3508
Product name: Istaroximehydrochloride
Packaging: 5mg
Price: $340
Updated: 2021/12/16

ChemScene

Product number: CS-1623
Product name: Istaroxime(hydrochloride)
Purity: 99.32%
Packaging: 10mg
Price: $426
Updated: 2021/12/16

ApexBio Technology

Product number: A3508
Product name: Istaroximehydrochloride
Packaging: 10mg
Price: $520
Updated: 2021/12/16

More

Less

PST2744 (hydrochloride) Chemical Properties,Usage,Production

Biological Activity

istaroxime hydrochloride(pst2744) is a novel inhibitor of na+/k+-atpase with ic50 value of 0.43±0.15μm [1].istaroxime is a steroidal drug unrelated to cardiac glycosides that improves cellular calcium cycling. the inhibition of na+/k+-atpase induces cytosolic calcium accumulation during systole (inotropism). clinical studies has been done with istaroxime in phase ii. istaroxime could be a promising alternative for patients with acute heart failure syndrome for whom the therapeutic options are currently limited [2].

in vitro

studies show that istaroxime can inhibit the activity of na+/k+-atpase from dog kidney without significant interaction with other several receptors. it demonstrates the selectivity of istaroxime. ex vivo studies show the inotropic effect can be achieved up to 60% for istaroxime. istaroxime can also increase the force of contraction of guinea pig paced left atria in the range 0.3 to 30μm. in vivo assays prove istaroxime is consistently safer than digoxin [1].

target

Na+/K+ ATPase

References

[1] r. micheletti, g. g. mattera, m. rocchetti, a. schiavone, m. f. loi, a. zaza, r. j. p. gagnol, s. de munari, p. melloni, p. carminati, g. bianchi, and p. ferrari. pharmacological profile of the novel inotropic agent (e,z)-3-((2-aminoethoxy)imino)androstane-6,17-dione hydrochloride (pst2744). the journal of pharmacology and experimental therapeutics. 2002, 303 (2): 592-600.
[2] suruchi aditya, aditya rattan. istaroxime: a rising star in acute heart failure. journal of pharmacology and pharmacotherapeutics. 2012, 3(4): 353-355.

PST2744 (hydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

PST2744 (hydrochloride) Suppliers

China 23 United States 7 Global 30

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 2384
Advantage: 58

SPIRO PHARMA

Tel
Fax: -
Email: eric_feng1954@126.com
Country: China
ProdList: 9248
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3866
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 27313
Advantage: 60

Lancrix Chemicals

Tel: 86-21-50817262
Fax: 86-21-57712035
Email: sales@lancrix.com
Country: China
ProdList: 1502
Advantage: 55

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 4009686088
Email: 3193328036@qq.com
Country: China
ProdList: 29785
Advantage: 68

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

More

Less

View Lastest Price from PST2744 (hydrochloride) manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Istaroxime hydrochloride 374559-48-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Istaroxime hydrochloride 374559-48-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

374559-48-5, PST2744 (hydrochloride)Related Search:

Pyridine hydrochloride Trimethylamine hydrochloride Betaine hydrochloride Methylamine hydrochloride

IstaroxiMe (hydrochloride)

PST 2744 (hydrochloride)

PST2744 (hydrochloride)

PST-2744 (hydrochloride)

(5alpha)-Androstane-3,6,17-trione 3-[O-(2-aminoethyl)oxime] monohydrochloride

Istaroxime hydrochloride, >=98%

Istaroxime hydrochloride(PST2744)

PST2774;PST-2774

374559-48-5

C21H32N2O3HCl