ChemicalBook > CAS DataBase List > (R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoic acid

(R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoic acid

Product Name
(R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoic acid
CAS No.
1012341-48-8
Chemical Name
(R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoic acid
Synonyms
E)-5-([1;LCZ-696-013;LCZ696 impurities2;LCZ-696 Impurity 58;LCZ696 impurities114;AHU-377 intermediate;LCZ696 Intermediate II;(R,E)-5-([1,1'-BiphenyL;Sacubitril intermediates;)-4-((tert-butoxycarbonyL
CBNumber
CB32723687
Molecular Formula
C23H27NO4
Formula Weight
381.46
MOL File
1012341-48-8.mol
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(R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoic acid Property

Melting point:
188 - 191°C
Boiling point:
595.6±50.0 °C(Predicted)
Density 
1.132±0.06 g/cm3(Predicted)
vapor pressure 
8.4-839.931Pa at 20℃
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
4.67±0.19(Predicted)
form 
Solid
color 
White to Off-White
InChI
InChI=1S/C23H27NO4/c1-16(21(25)26)14-20(24-22(27)28-23(2,3)4)15-17-10-12-19(13-11-17)18-8-6-5-7-9-18/h5-14,20H,15H2,1-4H3,(H,24,27)(H,25,26)/b16-14+/t20-/m0/s1
InChIKey
JXTNUXJSXXIIFE-VISDOYDDSA-N
SMILES
C(O)(=O)/C(/C)=C/[C@H](NC(OC(C)(C)C)=O)CC1=CC=C(C2=CC=CC=C2)C=C1
LogP
2.2-3.6 at 25℃ and pH2.5-7
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
M345205
Product name
(R,E)-5-([1,1-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoicAcid
Packaging
5g
Price
$90
Updated
2021/12/16
AK Scientific
Product number
1698DN
Product name
(R,E)-5-([1,1'-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoicacid
Packaging
5g
Price
$93
Updated
2021/12/16
AK Scientific
Product number
1698DN
Product name
(R,E)-5-([1,1'-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoicacid
Packaging
25g
Price
$176
Updated
2021/12/16
Crysdot
Product number
CD12187609
Product name
(R,E)-5-([1,1'-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoicacid
Purity
97%
Packaging
100g
Price
$218
Updated
2021/12/16
Chemenu
Product number
CM244547
Product name
(R,E)-5-([1,1''-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoicacid
Purity
95+%
Packaging
1000g
Price
$1440
Updated
2021/12/16
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(R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoic acid Chemical Properties,Usage,Production

Uses

(R,E)-5-([1,1-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-methylpent-2-enoic Acid is used in preparation of sacubitril intermediate using Nickel Salt catalyst.

Synthesis

149709-59-1

1012341-48-8

The general procedure for the synthesis of (R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methyl-2-pentenoic acid from ethyl (4R)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methyl-2-pentenoic acid was as follows: Step 1: 800 g of 95% ethanol and 400 g of pure water were mixed, compound I (1.3 mol) and lithium hydroxide (0.1833 mol) were added, and the reaction was held at reflux for 1 hour at 80 °C. After completion of the reaction, it was cooled to room temperature, activated carbon was added, heated to 42 °C and then continued to raise the temperature to 80 °C reflux. Incubate at room temperature for 2 hours. Step 2: The reaction mixture was thermally filtered and aqueous citric acid was added to the filtrate to terminate the reaction. Subsequently, the mixture was heated at reflux at 80°C for 1 hour and cooled to room temperature to crystallize. The crystals were collected by filtration and dried to give 55.4 g of dry Compound II in 79.05% molar yield and 99.20% purity.

References

[1] Patent: EP1903027, 2008, A1. Location in patent: Page/Page column 17
[2] Patent: CN106431993, 2017, A. Location in patent: Paragraph 0039; 0045; 0051; 0057
[3] Patent: CN106631903, 2017, A. Location in patent: Paragraph 0031; 0032; 0033
[4] Patent: CN106946742, 2017, A. Location in patent: Paragraph 0011

(R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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(R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoic acid Suppliers

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View Lastest Price from (R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoic acid manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
(R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoic acid 1012341-48-8
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-03-05
Hangzhou ICH Biofarm Co., Ltd
Product
(R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoic acid 1012341-48-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500KG
Release date
2023-07-06
Career Henan Chemical Co
Product
(R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoic acid 1012341-48-8
Price
US $1.00/KG
Min. Order
1KG
Purity
85.0-99.8%
Supply Ability
200kgs
Release date
2020-01-16

1012341-48-8, (R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoic acidRelated Search:

(2R,4S)-4-([1,1'-Biphenyl]-4-ylmethyl)-4-(4-ethoxy-4-oxobutanamido)-2-methylbutanoic acid AHU-377 (heMicalciuM salt) (2R,4S)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoate (2R,4R)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid (2S,4R)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid (S)-5-[(Biphenyl-4-yl)methyl]-1-(2,2-dimethylpropionyl)pyrrolidin-2-one ((R)-2-biphenyl-4-yl-1-forMylethyl)carbaMic acid t-butyl ester 2-Pyrrolidinone, 5-([1,1'-biphenyl]-4-ylMethyl)-3-Methyl-, (3R,5S)- Valsartan (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoic acid hydrochloride LCZ696 LCZ Impurity (S)-5-[(Biphenyl-4-yl)carbonyl]pyrrolidin-2-one AHU-377 (2R,4S)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoate (2S,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid LCZ696 InteMediate Sacubitril Impurity 72

  • (R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoic acid
  • (2E,4R)-5-[1,1'-biphenyl]-4-yl-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-2-Pentenoic acid
  • 5-Biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methyl-pent-2-enoic acid
  • 2-Pentenoic acid, 5-[1,1'-biphenyl]-4-yl-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-, (2E,4R)-
  • (R,E)-5-(biphenyl-4-yl)-4-(tert-butoxycarbonylamino)-2-methylpent-2-enoic acid
  • (R,E)-5-(biphenyl-4-yl)-4-(tert-butoxycarbonylamino)
  • (2E,4R)-5-[1,1'-Biphenyl]-4-yl-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-2-pentenoic acid AHU83
  • 1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoic acid
  • E)-5-([1
  • (R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoic acid###1012341-48-8 enantioMer
  • (R, E) -5-([1,1'-Biphenyl] -4-yl) -4-((tert-butoxycarbonyl) amino) -2-methyl-2-pentenoic acid
  • LCZ696(valsartan + sacubitril) impurity 30
  • (2E,4R)-5-{[1,1'-biphenyl]-4-yl}-4-{[(tert-butoxy)carbonyl]amino}-2-methylpent-2-enoic acid
  • (R,E)-5-([1,1'-BiphenyL
  • )-4-((tert-butoxycarbonyL
  • LCZ696 intermediates，(R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert- butoxycarbonyl)aMino)-2-Methylpent- 2-enoic acid
  • (E,4r)-2-methyl-4-[(2-methylpropan-2-yl)oxycarbonylamino]-5-(4-phenylphenyl)pent-2-enoic acid
  • (R,E)-5-([1,1'-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic acid (LCZ696 Impurity)
  • (R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino...
  • LCZ696 impurities114
  • LCZ696 impurities2
  • (R)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methyl-pent-(E)-2-enoic acidQ: What is (R)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methyl-pent-(E)-2-enoic acid Q: What is the CAS Number of (R)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methyl-pent-(E)-2-enoic acid Q: What is the storage condition of (R)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methyl-pent-(E)-2-enoic acid Q: What are the applications of (R)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methyl-pent-(E)-2-enoic acid
  • LCZ-696 Impurity 58
  • 2-Amino-4-(4-fluorbenzylamino)-3-ethoxycarbonylaminobenzene
  • (R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoic acid-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoic acid
  • LCZ-696-013
  • (R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoicaci
  • LCZ696 Intermediate II
  • Sacubitril intermediates
  • (R,E)-5-([1,I'-biphenyl]-4-yl)-4-((tert-butoxycarbony 1)amino)-2-methylpent-2-enoic acid
  • (2E, 4R) -5- [1,1 '- biphenyl] -4-yl-4- [[tert butoxycarbonyl] amino] -2-methyl-2-pentenoic acid
  • (2E,4R)-5-{[1,1’-biphenyl]-4-yl}-4-[(tert-butoxycarbonyl)amino]-2-methylpent-2-enoic acid
  • 2-Pentenoicacid,5-[1,1'-biphenyl]-4-yl-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-,(2E,4R)-
  • (2E, 4R) -5- [1,1 '- biphenyl] -4-yl-4- [[tert butoxycarbonyl] amino] -2-methyl-2-pentenoic acid
  • AHU-377 intermediate
  • (R)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methyl-pent-(E)-2-enoic acid
  • (R,E)-5-([1,1'-biphenyl]-4-base)-4-((tert-Butyloxycarbonyl)amino)-2-methyl-2-valerenoic acid
  • (2E,4R)-5-[1,1'-Biphenyl]-4-yl-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-2-pentenoic acid (Intermediate of Sacubitril Valsartan Sodium)
  • 1012341-48-8
  • 1212341-48-8
  • LCZ696
  • intermediate
  • intermediates
  • 1012341-48-8