2-Fluoro-4-hydroxybenzonitrile
- Product Name
- 2-Fluoro-4-hydroxybenzonitrile
- CAS No.
- 82380-18-5
- Chemical Name
- 2-Fluoro-4-hydroxybenzonitrile
- Synonyms
- FCP;422-810-7;2-Fluoro-4-hydroxybe;4-CYANO-3-FLUOROPHENOL;3-FLUORO-4-CYANOPHENOL;3-Fluoro-p-cyanophenol;3-fluoro-4-cyanopehenol;2-FLUORO-4-BENZONITRILE;3-FORMYL-5-BROMOPYRIDINE;Fluoro-4-hydroxybenzonitr
- CBNumber
- CB3273490
- Molecular Formula
- C7H4FNO
- Formula Weight
- 137.11
- MOL File
- 82380-18-5.mol
2-Fluoro-4-hydroxybenzonitrile Property
- Melting point:
- 123-125 °C (lit.)
- Boiling point:
- 285.4±25.0 °C(Predicted)
- Density
- 1,45 g/cm3
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- 4.7g/l
- pka
- 6.84±0.18(Predicted)
- form
- powder to crystal
- color
- White to Almost white
- PH
- 4.2 (H2O, 20℃)(saturated aqueous solution)
- BRN
- 4741066
- InChI
- InChI=1S/C7H4FNO/c8-7-3-6(10)2-1-5(7)4-9/h1-3,10H
- InChIKey
- REIVHYDACHXPNH-UHFFFAOYSA-N
- SMILES
- C(#N)C1=CC=C(O)C=C1F
- CAS DataBase Reference
- 82380-18-5(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi,T
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 26-36-37/39
- RIDADR
- 3276
- WGK Germany
- 2
- Hazard Note
- Irritant
- HazardClass
- 9
- PackingGroup
- III
- HS Code
- 29269095
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H319Causes serious eye irritation
H401Toxic to aquatic life
H411Toxic to aquatic life with long lasting effects
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- F0462
- Product name
- 2-Fluoro-4-hydroxybenzonitrile
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $21
- Updated
- 2025/07/31
- Product number
- F0462
- Product name
- 2-Fluoro-4-hydroxybenzonitrile
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $81
- Updated
- 2025/07/31
- Product number
- F595633
- Product name
- 2-Fluoro-4-hydroxybenzonitrile
- Packaging
- 5g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 002534
- Product name
- 2-Fluoro-4-hydroxybenzonitrile
- Purity
- 97+%
- Packaging
- 5g
- Price
- $8
- Updated
- 2021/12/16
- Product number
- 4637-3-05
- Product name
- 2-Fluoro-4-hydroxybenzonitrile
- Purity
- 99%
- Packaging
- 5G
- Price
- $18
- Updated
- 2021/12/16
2-Fluoro-4-hydroxybenzonitrile Chemical Properties,Usage,Production
Chemical Properties
Off-white Cryst
Uses
2-Fluoro-4-hydroxybenzonitrile may be used in the synthesis of 4-cyano-3-fluorophenyl 4-(hexadecyloxy) benzoate.
Uses
Intermediates of Liquid Crystals
General Description
2-Fluoro-4-hydroxybenzonitrile is a planar molecule. Its mol-ecules are arranged in linear chains via weak intermolecular O-HN hydrogen bonds.
Synthesis
105942-08-3
82380-18-5
General procedure for the synthesis of 2-fluoro-4-hydroxybenzonitrile from 4-bromo-2-fluorobenzonitrile: 4-bromo-2-fluorobenzonitrile (0.25 mmol), copper bromide (0.03 mmol), triethylamine (0.25 mmol, 1.0 eq.), formic acid (0.75 mmol, 3.0 eq.), and acetonitrile (179 mmol) were added to a reaction flask at room temperature. were used as reaction solvents. The reaction mixture was stirred at room temperature for 24 h under oxygen atmosphere. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, water (20 mL) and ethyl acetate (10 mL) were added to the reaction mixture for extraction, and the organic phases were combined and dried over anhydrous sodium sulfate. The dried organic phase was filtered and the filter cake was washed with ethyl acetate (5 mL × 3 times). Subsequently, the solvent was removed by rotary evaporator. The crude product was purified by column chromatography (eluent ratio: petroleum ether/ethyl acetate = 6:1) to afford the target product 2-fluoro-4-hydroxybenzonitrile in yellow liquid form in 82% yield.
References
[1] Organic Letters, 2018, vol. 20, # 3, p. 708 - 711
[2] Patent: CN107915586, 2018, A. Location in patent: Paragraph 0097-0100
2-Fluoro-4-hydroxybenzonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
2-Fluoro-4-hydroxybenzonitrile Suppliers
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View Lastest Price from 2-Fluoro-4-hydroxybenzonitrile manufacturers
- Product
- 2-Fluoro-4-hydroxybenzonitrile 82380-18-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-10-24
- Product
- 2-Fluoro-4-hydroxybenzonitrile 82380-18-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-28
- Product
- 2-Fluoro-4-hydroxybenzonitrile 82380-18-5
- Price
- US $8.00-0.60/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-01-14