General Description Uses Mechanism of action Side effects
ChemicalBook > CAS DataBase List > Panthenol

Panthenol

General Description Uses Mechanism of action Side effects
Product Name
Panthenol
CAS No.
16485-10-2
Chemical Name
Panthenol
Synonyms
PANTOTHENOL;DL-PANTHENOL;pantenol;DL-Panthenol 99%;pantenolo;PANTHENOL;panthenolum;DL- flooding;(+)-Magnolin;PANTHENOL,USP
CBNumber
CB3274109
Molecular Formula
C9H19NO4
Formula Weight
205.25
MOL File
16485-10-2.mol
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Panthenol Property

Melting point:
66-69 °C (lit.)
alpha 
0°(c=5, H2O)
Boiling point:
118-120 °C(Press: 0.02 Torr)
Density 
1.166±0.06 g/cm3(Predicted)
vapor pressure 
0.004Pa at 25℃
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly)
pka
13.03±0.20(Predicted)
form 
Solid
color 
White to Off-White
Water Solubility 
Soluble in water, ethanol, ether, chloroform, and propylene glycol.
Sensitive 
Hygroscopic
Merck 
14,2947
BRN 
1724945
InChIKey
SNPLKNRPJHDVJA-UHFFFAOYSA-N
LogP
-1.02 at 22℃
CAS DataBase Reference
16485-10-2(CAS DataBase Reference)
EPA Substance Registry System
Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl- (16485-10-2)
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Safety

Hazard Codes 
Xn
Risk Statements 
36/37/38-48-41-37/38-20/21/22
Safety Statements 
26-37-45-36/37/39-22
WGK Germany 
3
RTECS 
ES4316500
F 
3
TSCA 
Yes
HS Code 
29362400
Toxicity
mouse,LD50,intraperitoneal,10100mg/kg (10100mg/kg),Farmaco, Edizione Scientifica. Vol. 14, Pg. 43, 1959.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
295787
Product name
DL-Panthenol
Purity
99%
Packaging
100g
Price
$84.9
Updated
2024/03/01
Sigma-Aldrich
Product number
1494501
Product name
Panthenol, racemic
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$460
Updated
2024/03/01
TCI Chemical
Product number
P1318
Product name
DL-Panthenol
Purity
>98.0%(N)
Packaging
25g
Price
$27
Updated
2024/03/01
TCI Chemical
Product number
P1318
Product name
DL-Panthenol
Purity
>98.0%(N)
Packaging
500g
Price
$180
Updated
2024/03/01
Alfa Aesar
Product number
B25114
Product name
DL-Panthenol, 99%
Packaging
50g
Price
$46.65
Updated
2024/03/01
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Panthenol Chemical Properties,Usage,Production

General Description

Panthenol (also called pantothenol) is the alcohol analog of pantothenic acid (vitamin B5), and is thus a provitamin of B5. In organisms it is quickly oxidized to pantothenic acid. It is a viscous transparent liquid at room temperature. Panthenol is used as a moisturizer and to improve wound healing in pharmaceutical and cosmetic products.
Panthenol is a multi-functional active ingredient that would be useful in most skin care formulations. Its efficacy has been substantiated in numerous peer-reviewed journals. The biologically active form of Panthenol, D-panthenol (EU), is the stable alcohol analogue of vitamin B5, pantothenic acid (EU), and is quickly converted to vitamin B5 (pantothenate) in the body. Pantothenic acid is present in all living cells and acts as an essential nutritional component due to its role in the formation of acetyl-co-enzyme A in the early stages of metabolism. The main role of acetyl-co-enzyme A is to provide activated acetic acid into the citric acid cycle (Krebs Cycle). This produces carbon dioxide, water, and energy. Co-enzyme A also transfers to other molecules such as Nacetyl-glucosamine (EU) and acetylcholine (EU) to help in the production of steroids and the synthesis of fatty acids. Coenzyme A also helps the body detoxify foreign substances.

 

 

Uses

Panthenol, the active form of panthenol, is enzymatically cleaved to form pantothenic acid (Vitamin B5), which is an essential component of Coenzyme A that acts as a cofactor in many enzymatic reactions that are important for protein metabolism in the epithelium.
Due to its good penetration and high local concentrations, dexpanthanol is used in many topical products, such as ointments and lotions for treatment of dermatological conditions to relieve itching or promote healing. Dermatological effects of the topical use of dexpanthenol include increased fibroblast proliferation and accelerated re-epithelialization in wound healing. Furthermore, it acts as a topical protectant, moisturizer, and has demonstrated anti-inflammatory properties. The vitamin ingredient Panthenol is valued in skin and hair care applications for its moisturizing properties. It has anti-inflammatory effects and soothes irritated and sensitive skin. For hair care application it is known for its humectant properties and its ability to improve the resistance of hair to mechanical stress.

Mechanism of action

Pantothenic acid is a precursor of coenzyme A, which serves as a cofactor for a variety of enzyme-catalyzed reactions involving transfer of acetyl groups. The final step in the synthesis of acetylcholine consists of the choline acetylase transfer of acetyl group from acetylcoenzyme A to choline. Acetylcholine is the neurohumoral transmitter in the parasympathetic system and as such maintains the normal functions of the intestine. Decrease in acetylcholine content would result in decreased peristalsis and in extreme cases adynamic ileus.
Panthenol is well absorbed into the skin and quickly converted into Pantothenic acid by oxidation. Pantothenic acid is distributed into the cells and is converted to Acetyl Coenzyme-A (Acetyl CoA) in the cells of the epidermis. Human being require Vitamin B5 to synthesize Acetyl CoA which is an essential mediator to many biochemical reactions that sustain life (maintenance and repair of all cells) and which breaks down fats, carbohydrates and proteins for carbon dioxide, water, and energy generation. Furthermore, it synthesis fatty acids and sphingolipids, for stratum corneum lipid layers and cell membrane integrity & fluidity.

Side effects

Panthenol is generally well tolerated. In rare cases, skin irritation and contact allergies have been reported. Generally, topical panthenol formulations were well tolerated with minimal risk of skin irritation or sensitization.

Uses

vitamin B5 precursor, radioprotectant, antimalarial

Uses

panthenol (pro-vitamin B5) acts as a penetrating moisturizer. Panthenol appears to stimulate cellular proliferation and aid in tissue repair. Studies indicate that when topically applied, panthenol penetrates the skin and gets converted into pantothenic acid, a B complex vitamin. Such action could possibly influence the skin’s natural resources of pantothenic acid. It imparts a nonirritant, non-sensitizing, moisturizing, and conditioning feel and promotes normal keratinization and wound-healing. Panthenol protects the skin against sunburn, provides relief for existing sunburn, and enhances the natural tanning process. Panthenol’s humectant character enables it to hold water in the product or attract water from the environment, resulting in a moisturizing effect. It enhances skin suppleness, and claims are that it also acts as an anti-inflammatory agent. It is considered a non-comedogenic raw material.

Uses

DL-Panthenol is used in the topical treatment of skin disorders, such as minor irritations and skin burns. Also used in the strengthening and treatment of hair.

General Description

Panthenol is an alcohol derivative of pantothenic acid, a component of the B complex vitamins and an essential component of a normally functioning epithelium. Panthenol exists in two optically active forms, both of which are used in pharmaceutical preparations. While pantothenic acid is optically active, only the dextrorotatory form is biologically active. Dexpanthenol, the active form of panthenol, is enzymatically cleaved to form pantothenic acid (Vitamin B5), which is an essential component of Coenzyme A that acts as a cofactor in many enzymatic reactions that are important for protein metabolism in the epithelium.

Flammability and Explosibility

Non flammable

Panthenol Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Panthenol manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
Panthenol 16485-10-2
Price
US $500.00-300.00/kg
Min. Order
0.0010000000474974513kg
Purity
99%
Supply Ability
5000
Release date
2024-08-23
HebeiShuoshengImportandExportco.,Ltd
Product
Panthenol 16485-10-2
Price
US $6.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000KG/Month
Release date
2024-08-09
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Dl-Panthenol 16485-10-2
Price
US $35.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000kg/Week
Release date
2024-05-07

16485-10-2, PanthenolRelated Search:

N,N-Dimethylacetamide N,N-Dimethylformamide Dexpanthenol hopantenic acid Dexpanthenol iMpurity F DIHYDRO-4,4-DIMETHYL-2,3-FURANDIONE Hopantenic Sodium D-pantothenate D-PANTOTHENIC ACID PANTOTHENIC ACID CALCIUM SALT MONOHYDRATE DL-PANTHENOL ETHYL ETHER,DL-PANTHENOL ETHYL ETHER 99-102% Calcium D-Pantothenate Panthenol, Racemic D-panthenol ethyl ether,DL-PANTHENOL ETHYL ETHER Butyramide PANTOTHENIC ACID 2,4-DI-O-BETA-D-GALACTOPYRANOSIDE L-Panthenol Panthenol

  • 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-,(+-)-Butanamide
  • 4-dihydroxy-n-(3-hydroxypropyl)-3,3-dimethyl-(+-)-butanamid
  • 4-dihydroxy-n-(3-hydroxypropyl)-3,3-dimethyl-(+-)-butyramid
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  • 4-dihydroxy-n-(3-hydroxypropyl)-3,3-dimethyl-dl-butyramid
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  • Butyramide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (+-)- (8CI)
  • DL-Pantothenyl alcohol, (±)-α,γ-Dihydroxy-N-(3-hydroxypropyl)-β,β-dimethylbutyramide, (±)-2,4-Dihydroxy-3,3-dimethylbutyric 3-hydroxypropylamide
  • [S,(-)]-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide
  • (±)-α,γ-Dihydroxy-N-(3-hydroxypropyl)-β,β-dimethylbutyramide (±)-2,4-Dihydroxy-3,3-dimethylbutyric 3-hydroxypropylamide
  • 3-(2,4-Dihydroxy-3,3-dimethylbutyramido)-1
  • DL-Panthenol,(±)-α,γ-Dihydroxy-N-(3-hydroxypropyl)-β,β-dimethylbutyramide, (±)-2,4-Dihydroxy-3,3-dimethylbutyric 3-hydroxypropylamide, DL-Pantothenyl alcohol
  • Panthenol, Racemic (200 mg)
  • 3-(2,4-Dihydroxy-3,3-dimethylbutyramido)-1-propanol 2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide
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  • DL- flooding
  • (2RS)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide
  • DL-Panthenol, 98.5%
  • PANTOTHENOL
  • (+/-)-PANTOTHENYL ALCOHOL
  • (+/-)-PANTHENOL
  • PANTHENOL
  • (+/-)-2,4-DIHYDROXY-3,3-DIMETHYLBUTYRIC 3-HYDROXY-PROPYLAMIDE
  • 2,4-DIHYDROXY-N-(3-HYDROXYPROPYL)-3,3-DIMETHYLBUTYRAMIDE
  • 3-(2,4-DIHYDROXY-3,3-DIMETHYLBUTYRAMIDO)-1-PROPANOL
  • DL-Panthenol&gt
  • 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-
  • DL-Panthenol 50% liquid
  • Dl-Panthenol USP/Panthenol/CAS No. 16485-10-2/Provitamin B5
  • d panthenol powder
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