LY2409881

Product Name: LY2409881
CAS No.: 946518-61-2
Chemical Name: LY2409881
Synonyms: 2-(5-chloro-2-((3-(4-methylpiperazin-1-yl)propyl)amino)pyrimidin-4-yl)-N-cyclopropylbenzo[b]thiophene-4-carboxamide;2-[5-Chloro-2-[[3-(4-methyl-1-piperazinyl)propyl]amino]-4-pyrimidinyl]-N-cyclopropylbenzo[b]thiophene-4-carboxamide;Benzo[b]thiophene-4-carboxamide, 2-[5-chloro-2-[[3-(4-methyl-1-piperazinyl)propyl]amino]-4-pyrimidinyl]-N-cyclopropyl-;2-{5-chloro-2-[3-(4-methyl-piperazin-1-yl)-propylamino]-pyrimidin-4-yl}-benzo[b]thiophene-4-carboxylic acid cyclopropylamide
CBNumber: CB32744877
Molecular Formula: C24H29ClN6OS
Formula Weight: 485.04
MOL File: 946518-61-2.mol

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LY2409881 Property

Density: 1.37±0.1 g/cm3(Predicted)
pka: 14.17±0.20(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-3956
Product name: LY2409881
Packaging: 5mg
Price: $132
Updated: 2021/12/16

ChemScene

Product number: CS-3956
Product name: LY2409881
Packaging: 10mg
Price: $216
Updated: 2021/12/16

ChemScene

Product number: CS-3956
Product name: LY2409881
Packaging: 50mg
Price: $780
Updated: 2021/12/16

ChemScene

Product number: CS-3956
Product name: LY2409881
Packaging: 100mg
Price: $1092
Updated: 2021/12/16

Chemenu

Product number: CM156907
Product name: 2-(5-chloro-2-((3-(4-methylpiperazin-1-yl)propyl)amino)pyrimidin-4-yl)-N-cyclopropylbenzo[b]thiophene-4-carboxamide
Purity: 98%
Packaging: 100mg
Price: $534
Updated: 2021/12/16

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LY2409881 Chemical Properties,Usage,Production

Uses

LY2409881 is a selective IκB kinase β (IKK2) inhibitor with an IC50 of 30 nM.

in vivo

A well-established xenograft model of DLBCL is used to confirm the activity of LY2409881 in vivo. SCID-beige mice implanted with LY10 cell-derived tumors are given intraperitoneal injections of LY2409881 twice weekly at three different doses: 50, 100, and 200 mg/kg. The treatments are well tolerated, resulting in no death or severe morbidity of the mice. The average tumor volume is graphed as a function of time for each treatment group. The rates of tumor volume growth of the treatment groups are all significantly slower than the untreated control group (P≤0.01)^[1].

IC 50

IKK2: 30 nM (IC₅₀)

References

[1] Deng C, et al. The novel IKK2 inhibitor LY2409881 potently synergizes with histone deacetylase inhibitors in preclinical models of lymphoma through the downregulation of NF-κB. Clin Cancer Res. 2015 Jan 1;21(1):134-45. DOI:10.1158/1078-0432.CCR-14-0384

LY2409881 Preparation Products And Raw materials

Raw materials

Preparation Products

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LY2409881 Suppliers

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946518-61-2, LY2409881Related Search:

LY 294002 Hydrochloride LY-3177833 2-(4-((4-((1-cyclopropyl-3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)oxy)pyridin-2-yl)amino)pyridin-2-yl)propan-2-ol LY3214996 Cyclo[Phe-Tyr-Lys(iPr)-D-Arg-2-Nal-Gly-D-Glu]-Lys(iPr)-NH2 LY3023414 LY2955303 LY 334370 HYDROCHLORIDE

2-[5-Chloro-2-[[3-(4-methyl-1-piperazinyl)propyl]amino]-4-pyrimidinyl]-N-cyclopropylbenzo[b]thiophene-4-carboxamide

2-(5-chloro-2-((3-(4-methylpiperazin-1-yl)propyl)amino)pyrimidin-4-yl)-N-cyclopropylbenzo[b]thiophene-4-carboxamide

2-{5-chloro-2-[3-(4-methyl-piperazin-1-yl)-propylamino]-pyrimidin-4-yl}-benzo[b]thiophene-4-carboxylic acid cyclopropylamide

Benzo[b]thiophene-4-carboxamide, 2-[5-chloro-2-[[3-(4-methyl-1-piperazinyl)propyl]amino]-4-pyrimidinyl]-N-cyclopropyl-

946518-61-2

C24H29ClN6OS