4-MERCAPTOPHENYLACETIC ACID Property

Melting point:

105-109 °C (lit.)

Boiling point:

336.0±17.0 °C(Predicted)

Density 

1.299±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

Acetonitrile (Slightly), DMSO (Slightly)

pka

4.21±0.10(Predicted)

form 

Solid

color 

Off-White

Water Solubility 

Slightly soluble in water. Soluble in Dichloromethane, Ethanol and Methanol

Sensitive 

Air Sensitive

Safety

Hazard Codes 

Xi

Risk Statements 

37/38-41

Safety Statements 

26-36/37/39

RIDADR 

UN 3335

WGK Germany 

3

HS Code 

2930909899

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

4-MERCAPTOPHENYLACETIC ACID Chemical Properties,Usage,Production

Chemical Properties

4-MERCAPTOPHENYLACETIC ACID is White Powder

Uses

4-MERCAPTOPHENYLACETIC ACID is a redox buffer that increases the folding rate of disulfide-containing proteins realative to traditional buffers such as glutathione and glutathione-disulfide. A useful synthetic intermediate for the preparation of novel antiinflammatory agents.

Uses

4-Mercaptophenylacetic acid has been used in the preparation of small ubiquitin-like modifier peptides from bis(2-sulfanylethyl)amido peptide via sequential native chemical ligation.
It can be used:

• On-resin preparation of peptide-^α thiophenylesters which are used in a chemical ligation process for the chemical synthesis of peptides.
• In one pot deprotection of (acetamido-methyl)cysteine following native chemical ligation and/or desulfurization method for the preparation of peptides.
• Palladium facilitated deprotection of N-terminal cysteine through native chemical ligation method for the preparation of synthetically challenging proteins.