ChemicalBook > CAS DataBase List > METHYL 4-BROMO-2-BROMOMETHYL-BENZOATE

METHYL 4-BROMO-2-BROMOMETHYL-BENZOATE

Product Name
METHYL 4-BROMO-2-BROMOMETHYL-BENZOATE
CAS No.
78471-43-9
Chemical Name
METHYL 4-BROMO-2-BROMOMETHYL-BENZOATE
Synonyms
4-BroMo-2-broMoMethyl-benzoic acid Methyl ester;Methyl 2-bromomethyl-4-bromobenzoate;METHYL 4-BROMO-2-BROMOMETHYL-BENZOATE;Methyl4-bromo-2-(bromomethyl)benzoate,96%;1-(4-BROMO-2-(BROMOMETHYL)PHENYL)ETHANONE;Benzoic acid, 4-broMo-2-(broMoMethyl)-, Methyl ester
CBNumber
CB3276633
Molecular Formula
C9H8Br2O2
Formula Weight
307.97
MOL File
78471-43-9.mol
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METHYL 4-BROMO-2-BROMOMETHYL-BENZOATE Property

Melting point:
76-78℃
Boiling point:
364.3±32.0 °C(Predicted)
Density 
1.780±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
powder to crystal
color 
White to Light yellow to Light orange
Water Solubility 
Slightly soluble in water.
InChI
InChI=1S/C9H8Br2O2/c1-13-9(12)8-3-2-7(11)4-6(8)5-10/h2-4H,5H2,1H3
InChIKey
SGFACFBLUAWICV-UHFFFAOYSA-N
SMILES
C(OC)(=O)C1=CC=C(Br)C=C1CBr
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Safety

RIDADR 
UN 3261 8/PG III
HazardClass 
8
PackingGroup 
III
HS Code 
2916310090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical
Product number
M2941
Product name
Methyl 4-Bromo-2-(bromomethyl)benzoate
Purity
>97.0%(GC)
Packaging
200mg
Price
$41
Updated
2025/07/31
TCI Chemical
Product number
M2941
Product name
Methyl 4-Bromo-2-(bromomethyl)benzoate
Purity
>97.0%(GC)
Packaging
1g
Price
$155
Updated
2025/07/31
TRC
Product number
M295948
Product name
Methyl 4-Bromo-2-(bromomethyl)benzoate
Packaging
250mg
Price
$45
Updated
2021/12/16
TRC
Product number
M295948
Product name
Methyl 4-Bromo-2-(bromomethyl)benzoate
Packaging
500mg
Price
$70
Updated
2021/12/16
Apolloscientific
Product number
OR400314
Product name
Methyl 4-Bromo-2-(bromomethyl)benzoate
Packaging
1g
Price
$53
Updated
2021/12/16
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METHYL 4-BROMO-2-BROMOMETHYL-BENZOATE Chemical Properties,Usage,Production

Uses

Methyl 4-bromo-2-(bromomethyl)benzoate is used as pharmaceutical intermediate.

Synthesis

99548-55-7

78471-43-9

General procedure for the synthesis of methyl 4-bromo-2-bromomethylbenzoate from methyl 4-bromo-2-methylbenzoate: a mixture of methyl 4-bromo-2-methylbenzoate (1 g, 4.4 mmol), N-bromosuccinimide (NBS, 0.80 g, 4.4 mmol), benzoyl peroxide (BPO, 56 mg, 0.23 mmol) and carbon tetrachloride (CCl4 , 20 mL) mixture was stirred and reacted at 85°C for 2 hours. Upon completion of the reaction, the mixture was filtered through a silica gel pad and the filtrate was subsequently concentrated to afford the target product methyl 4-bromo-2-bromomethylbenzoate (1.3 g, 97% yield).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 6, p. 1324 - 1328
[2] Patent: WO2018/68017, 2018, A1. Location in patent: Page/Page column 126
[3] Patent: WO2007/339, 2007, A1. Location in patent: Page/Page column 35-36
[4] Patent: US2010/222363, 2010, A1. Location in patent: Page/Page column 13
[5] Patent: WO2007/337, 2007, A1. Location in patent: Page/Page column 30

METHYL 4-BROMO-2-BROMOMETHYL-BENZOATE Preparation Products And Raw materials

Raw materials

Preparation Products

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METHYL 4-BROMO-2-BROMOMETHYL-BENZOATE Suppliers

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View Lastest Price from METHYL 4-BROMO-2-BROMOMETHYL-BENZOATE manufacturers

Shanghai Rlavie Technology Co ltd
Product
Methyl 2-bromomethyl-4-bromobenzoate 78471-43-9
Price
US $0.00-0.00/KG
Min. Order
1g
Purity
98%min
Supply Ability
500kgs/month
Release date
2021-11-20
Career Henan Chemical Co
Product
METHYL 4-BROMO-2-BROMOMETHYL-BENZOATE 78471-43-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000KGS
Release date
2020-01-08

78471-43-9, METHYL 4-BROMO-2-BROMOMETHYL-BENZOATERelated Search:

METHYL 4-CHLORO-3-METHYLBENZOATE METHYL 4-[(4-METHYLPIPERAZIN-1-YL)METHYL]BENZOATE METHYL 4-(TRIFLUOROMETHYL)NICOTINATE METHYL 4-AMINO-6-INDOLECARBOXYLATE 2-(BROMOMETHYL)BENZYL ALCOHOL, 95% BENZOIC ACID,4-BROMO-2-METHYL-,METHYL ESTER 2-(Bromomethyl)benzoic acid METHYL 4-BROMO-2-BROMOMETHYL-BENZOATE Methyl 2-bromomethylbenzoate

  • METHYL 4-BROMO-2-BROMOMETHYL-BENZOATE
  • Benzoic acid, 4-broMo-2-(broMoMethyl)-, Methyl ester
  • Methyl 2-bromomethyl-4-bromobenzoate
  • 1-(4-BROMO-2-(BROMOMETHYL)PHENYL)ETHANONE
  • 4-BroMo-2-broMoMethyl-benzoic acid Methyl ester
  • Methyl4-bromo-2-(bromomethyl)benzoate,96%
  • 78471-43-9