BC 11-38
- Product Name
- BC 11-38
- CAS No.
- 686770-80-9
- Chemical Name
- BC 11-38
- Synonyms
- BC-11-38,PDE-11;BC 11-38, 10 mM in DMSO;BC-11-38, PDE-11 inhibitor;6,7-Dihydro-3-phenyl-2-(propylthio)thieno[3,2-d]pyrimidin-4(3H)one;3-phenyl-2-(propylthio)-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one;Thieno[3,2-d]pyrimidin-4(3H)-one, 6,7-dihydro-3-phenyl-2-(propylthio)-;cortisol,adrenocortical,Phosphodiesterase (PDE),cAMP,BC 11 38,Inhibitor,production,inhibit,levels,cells,BC11-38,BC 1138
- CBNumber
- CB33037165
- Molecular Formula
- C15H16N2OS2
- Formula Weight
- 304.43
- MOL File
- 686770-80-9.mol
BC 11-38 Property
- storage temp.
- RT
- solubility
- Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 14 mg/ml with warming).
- form
- solid
- color
- White
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
N-Bromosuccinimide Price
- Product number
- 20167
- Product name
- BC-11-38
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $68
- Updated
- 2024/03/01
- Product number
- 20167
- Product name
- BC-11-38
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- 20167
- Product name
- BC-11-38
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $252
- Updated
- 2024/03/01
- Product number
- B129345
- Product name
- BC11-38
- Packaging
- 25mg
- Price
- $285
- Updated
- 2021/12/16
- Product number
- B7673
- Product name
- BC11-38
- Packaging
- 10mg
- Price
- $291
- Updated
- 2021/12/16
BC 11-38 Chemical Properties,Usage,Production
Description
BC-11-38 (686770-80-9) is a? potent and selective inhibitor of phosphodiesterase PDE11 (IC50=0.28 μM).1? IC50s for PDE1-10 are greater than 100 μM. Restores the ability of p54nrb / NONOKD cells to generate cAMP in response to ACTH stimulation and the production of cortisol and DHEA in response to cAMP signaling.2
Uses
BC 11-38 is a selective inhibitor of phosphodiesterase 11. Potent PDE-11 inhibitor
IC 50
PDE10: >100 μM (IC50); PDE11: 0.28 μM (IC50)
References
[1] OZGE CEYHAN Charles S H Kivanc Birsoy. Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen.[J]. Chemistry & biology, 2012, 19 1: 155-163. DOI:10.1016/j.chembiol.2011.12.010
[2] JIA YANG LU Marion B S. p54nrb/NONO regulates cyclic AMP-dependent glucocorticoid production by modulating phosphodiesterase mRNA splicing and degradation.[J]. Molecular and Cellular Biology, 2015, 35 7: 1223-1237. DOI:10.1128/mcb.00993-14
BC 11-38 Preparation Products And Raw materials
Raw materials
Preparation Products
BC 11-38 Suppliers
- Tel
- 888-539-0666
- Fax
- 888-539-0666
- info@emmx.com
- Country
- United States
- ProdList
- 8447
- Advantage
- 60
- Tel
- +86-400-851-9921
- Fax
- +86-10-82826195
- sales@pharmacodia.com
- Country
- China
- ProdList
- 2317
- Advantage
- 55
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9803
- Advantage
- 58
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 15076683720
- Fax
- 022-23754520
- klq@cw-bio.com
- Country
- China
- ProdList
- 8011
- Advantage
- 55
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 86-(0)29-85992781 17792393971
- info@lynnchem.com
- Country
- China
- ProdList
- 4587
- Advantage
- 58
- Tel
- 44-20819178-90 02081917890
- Fax
- (0)2080432064
- info@novachemistry.com
- Country
- United Kingdom
- ProdList
- 4381
- Advantage
- 58
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- sales@chemegen.com
- Country
- China
- ProdList
- 11218
- Advantage
- 58