N-Benzyloxycarbonyl-6-aminohexanoic acid
- Product Name
- N-Benzyloxycarbonyl-6-aminohexanoic acid
- CAS No.
- 1947-00-8
- Chemical Name
- N-Benzyloxycarbonyl-6-aminohexanoic acid
- Synonyms
- VIB 19;VIB 197;Z-ACP-OH;NSC 92812;Z-ε-Ahx-OH;Z-6-ACA-OH;Z-e-Acp-OH;Z-(CH2)5-OH;Z-AHX(6)-OH;Z-ACP(6)-OH
- CBNumber
- CB3304415
- Molecular Formula
- C14H19NO4
- Formula Weight
- 265.3
- MOL File
- 1947-00-8.mol
N-Benzyloxycarbonyl-6-aminohexanoic acid Property
- Melting point:
- 54-57 °C(lit.)
- Boiling point:
- 408.52°C (rough estimate)
- Density
- 1.162±0.06 g/cm3 (20 ºC 760 Torr)
- refractive index
- 1.5110 (estimate)
- Flash point:
- >230 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 4.76±0.10(Predicted)
- color
- White to Off-White
- BRN
- 2288508
- CAS DataBase Reference
- 1947-00-8(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 299529
- Product name
- Z-6-Aminohexanoic acid
- Purity
- 98%
- Packaging
- 5g
- Price
- $73.9
- Updated
- 2023/06/20
- Product number
- C2757
- Product name
- N-Carbobenzoxy-6-aminohexanoic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $62
- Updated
- 2025/07/31
- Product number
- C2757
- Product name
- N-Carbobenzoxy-6-aminohexanoic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $247
- Updated
- 2025/07/31
- Product number
- B285885
- Product name
- N-Benzyloxycarbonyl-6-aminocaproicAcid
- Packaging
- 2g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- B285885
- Product name
- N-Benzyloxycarbonyl-6-aminocaproicAcid
- Packaging
- 5G
- Price
- $55
- Updated
- 2021/12/16
N-Benzyloxycarbonyl-6-aminohexanoic acid Chemical Properties,Usage,Production
Chemical Properties
White Solid
Uses
peptide synthesis
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
501-53-1
60-32-2
1947-00-8
Benzyl chloroformate (1.63 mL, 11.45 mmol) was added slowly and dropwise to a stirred suspension of 6-aminohexanoic acid (1 g, 7.62 mmol) and K2CO3 (2.1 g, 15.2 mmol) in THF (20 mL). The reaction mixture was stirred at room temperature for 16 hours. Upon completion of the reaction, the reaction was quenched with ethyl acetate and deionized water. The aqueous phase was separated and the pH of the aqueous phase was adjusted to 2 with 4N HCl and subsequently extracted twice with ethyl acetate (10 mL). The organic phases were combined, dried with anhydrous Na2SO4, filtered and concentrated under reduced pressure. The resulting crude product of Cbz-6-aminohexanoic acid was used directly in the next reaction without further purification in 99% yield.
References
[1] Journal of Organic Chemistry, 2007, vol. 72, # 16, p. 6162 - 6170
[2] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 15, p. 3332 - 3336
[3] Israel Journal of Chemistry, 2000, vol. 40, # 3-4, p. 335 - 341
[4] Synthetic Communications, 2004, vol. 34, # 13, p. 2415 - 2424
[5] Chemistry - A European Journal, 2008, vol. 14, # 27, p. 8169 - 8176
N-Benzyloxycarbonyl-6-aminohexanoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from N-Benzyloxycarbonyl-6-aminohexanoic acid manufacturers
- Product
- N-Benzyloxycarbonyl-6-aminohexanoic acid 1947-00-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1T+
- Release date
- 2024-01-05
- Product
- N-Benzyloxycarbonyl-6-aminohexanoic acid 1947-00-8
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-07