N-Benzyloxycarbonyl-D-aspartic acid
- Product Name
- N-Benzyloxycarbonyl-D-aspartic acid
- CAS No.
- 78663-07-7
- Chemical Name
- N-Benzyloxycarbonyl-D-aspartic acid
- Synonyms
- Z-D-ASP-OH;Z-D-ASP;CBZ-D-ASP-OH;N-CBZ-D-ASP-OH;Cbz-D-Aspartic;Z-D-ASPARTIC ACID;CBZ-D-ASPARTIC ACID;Z-D-Asp-OH, >=98.0%;Z-
D -Asp-OH;Z-D-aspartic acid99% - CBNumber
- CB4242062
- Molecular Formula
- C12H13NO6
- Formula Weight
- 267.23
- MOL File
- 78663-07-7.mol
N-Benzyloxycarbonyl-D-aspartic acid Property
- Melting point:
- 117 °C
- Boiling point:
- 472.8±45.0 °C(Predicted)
- Density
- 1.404±0.06 g/cm3(Predicted)
- refractive index
- -10 ° (C=7, AcOH)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- Methanol (Sparingly)
- pka
- 3.75±0.23(Predicted)
- form
- Solid
- color
- White to Off-White
- optical activity
- Consistent with structure
- BRN
- 2566464
- CAS DataBase Reference
- 78663-07-7(CAS DataBase Reference)
Safety
- Safety Statements
- 24/25
- WGK Germany
- 3
- HS Code
- 29242990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- 95965
- Product name
- Z-D-Asp-OH
- Purity
- ≥98.0%
- Packaging
- 5g
- Price
- $49.3
- Updated
- 2022/05/15
- Product number
- C0689
- Product name
- N-Carbobenzoxy-D-aspartic Acid
- Purity
- >98.0%(T)
- Packaging
- 1g
- Price
- $16
- Updated
- 2025/07/31
- Product number
- C0689
- Product name
- N-Carbobenzoxy-D-aspartic Acid
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $34
- Updated
- 2025/07/31
- Product number
- C176280
- Product name
- N-Carbobenzyloxy-D-asparticAcid
- Packaging
- 5g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 242660
- Product name
- Z-D-aspartic acid 99+%
- Packaging
- 5g
- Price
- $156
- Updated
- 2021/12/16
N-Benzyloxycarbonyl-D-aspartic acid Chemical Properties,Usage,Production
Chemical Properties
Off-White Solid
Uses
A competitive inhibitor of indole-3-acetyl-L-aspartic acid hydrolase of Enterobacter agglomerans.
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
1783-96-6
501-53-1
78663-07-7
The general procedure for the synthesis of Cbz-D-aspartic acid from D-aspartic acid and benzyl chloroformate is as follows: 1. 6 M NaOH solution was added to 500 mL of distilled water at 0 °C and the pH of the solution was adjusted to 13. Subsequently, 65 g (489 mmol) of (R)-aspartic acid was added. 2. 141 g (831 mmol, 1.7 eq.) of benzyl chloroformate was slowly added to the above solution under magnetic stirring. 3. The reaction mixture was stirred at room temperature for 2 days. 4. 4. After completion of the reaction, the mixture was washed with ether and the aqueous phase was acidified with 6 N HCl to pH < 2. 5. 5. The acidified aqueous phase was extracted with ethyl acetate (AcOEt) and the organic phases were combined. 6. The organic phase was dried with anhydrous Na2SO4, filtered, and concentrated in a rotary evaporator to give 80 g of a clear, colorless gelatinous product in 59% yield. Product Characterization: - MS (ESI) m/e (MH+): 266 - 1H-NMR (CDCl3, 400 MHz): δ 7.21-7.21 (m, 5H), 6.14 (d, J = 8.4 Hz, 1H), 5.05 (s, 2H), 4.60 (m, 1H), 2.99 (m, 1H), 2.75 (m, 1H).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 3, p. 1040 - 1044
[2] Journal of the Chemical Society - Perkin Transactions 1, 1997, # 17, p. 2495 - 2511
[3] Asian Journal of Chemistry, 2013, vol. 25, # 11, p. 5948 - 5950
[4] Patent: WO2008/61208, 2008, A2. Location in patent: Page/Page column 31-32; 34-35
[5] Patent: US6660769, 2003, B1. Location in patent: Page column 13-14
N-Benzyloxycarbonyl-D-aspartic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from N-Benzyloxycarbonyl-D-aspartic acid manufacturers
- Product
- N-Benzyloxycarbonyl-D-aspartic acid 78663-07-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-25
- Product
- N-Benzyloxycarbonyl-D-aspartic acid 78663-07-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20kg
- Release date
- 2018-08-22