ChemicalBook > CAS DataBase List > Hydroxy-PEG5-t-butyl acetate

Hydroxy-PEG5-t-butyl acetate

Product Name
Hydroxy-PEG5-t-butyl acetate
CAS No.
1807530-05-7
Chemical Name
Hydroxy-PEG5-t-butyl acetate
Synonyms
OH-PEG5-CH2COOtBu;Hydroxy-PEG4-O-Boc;Hydroxy-PEG5-C1-Boc;Hydroxy-PEG5-CH2COOtBu;Hydroxy-PEG5-CH3COOtBu;Hydroxy-PEG5-t-butyl acetate;tert-butyl 17-hydroxy-3,6,9,12,15-pentaoxaheptadecanoate;tert-Butyl 17-Hydroxy-3,6,9,12,15-pentaoxa-1-heptadecanoate;tert-butyl 17-hydroxy-3,6,9,12,15-pentaoxaheptadecan-1-oate;3,6,9,12,15-Pentaoxaheptadecanoic acid, 17-hydroxy-, 1,1-dimethylethyl ester
CBNumber
CB33059125
Molecular Formula
C16H32O8
Formula Weight
352.42
MOL File
1807530-05-7.mol
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Hydroxy-PEG5-t-butyl acetate Property

Boiling point:
432.4±40.0 °C(Predicted)
Density 
1.082±0.06 g/cm3(Predicted)
storage temp. 
Store at 0-8 °C
solubility 
Soluble in Water, DMSO, DCM, DMF
pka
14.36±0.10(Predicted)
form 
Liquid
color 
Colorless to light yellow
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Safety

HS Code 
2918999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Activate Scientific
Product number
AS103933
Product name
HO-PEG5-CH2COOtBu
Purity
95+%
Packaging
250mg
Price
$331
Updated
2021/12/16
BroadPharm
Product number
BP-22097
Product name
Hydroxy-PEG5-CH2CO2tBu
Purity
95%
Packaging
250mg
Price
$350
Updated
2021/12/16
Activate Scientific
Product number
AS103933
Product name
HO-PEG5-CH2COOtBu
Purity
95+%
Packaging
1g
Price
$728
Updated
2021/12/16
Matrix Scientific
Product number
179906
Product name
[2-(2-{2-[2-(2-Hydroxyethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-acetic acid tert-butyl ester
Purity
95%
Packaging
1g
Price
$990
Updated
2021/12/16
AK Scientific
Product number
0372DY
Product name
Hydroxy-PEG5-CH2CO2tBu
Packaging
1g
Price
$998
Updated
2021/12/16
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Hydroxy-PEG5-t-butyl acetate Chemical Properties,Usage,Production

Description

Hydroxy-PEG5-CH2CO2tBu is a PEG linker containing a hydroxyl group with a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Uses

Hydroxy-PEG5-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Hydroxy-PEG5-t-butyl acetate Preparation Products And Raw materials

Raw materials

Preparation Products

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Hydroxy-PEG5-t-butyl acetate Suppliers

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1807530-05-7, Hydroxy-PEG5-t-butyl acetateRelated Search:

Hydroxy-PEG2-CH2CO2H Hydroxy-PEG3-t-butyl acetate Hydroxy-PEG1-CH2CO2tBu Hydroxy-PEG6-CH2CO2tBu tert-butyl 18-hydroxy-3,6,11,16-tetraoxaoctadecanoate PEG4-tert-butyl acetate tert-butyl 19-hydroxy-4,8,12,16-tetraoxanonadecanoate Azido-PEG1-CH2CO2tBu Bromo-PEG1-CH2CO2tBu Hydroxy-PEG14-t-butly ester 3-[2-(2-Hydroxyethoxy)ethoxy]propanoic acid PEG4-acid Hydroxy-PEG7-t-butyl acetate PEG8-t-butly ester PEG14-t-butly ester Hydroxy-PEG3-Mes Bromo-PEG2-CH2CO2tBu

  • Hydroxy-PEG5-CH2COOtBu
  • Hydroxy-PEG5-t-butyl acetate
  • OH-PEG5-CH2COOtBu
  • tert-butyl 17-hydroxy-3,6,9,12,15-pentaoxaheptadecanoate
  • [2-(2-{2-[2-(2-Hydroxyethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-acetic acid tert-butyl ester
  • tert-butyl 17-hydroxy-3,6,9,12,15-pentaoxaheptadecan-1-oate
  • tert-Butyl 17-Hydroxy-3,6,9,12,15-pentaoxa-1-heptadecanoate
  • Hydroxy-PEG4-O-Boc
  • 3,6,9,12,15-Pentaoxaheptadecanoic acid, 17-hydroxy-, 1,1-dimethylethyl ester
  • HO-PEG5-CH2COOtBu/3,6,9,12,15-Pentaoxaheptadecanoic acid, 17-hydroxy-, 1,1-dimethylethyl ester
  • tert-butyl 2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]acetate
  • Hydroxy-PEG5-CH3COOtBu
  • Hydroxy-PEG5-C1-Boc
  • 1807530-05-7
  • peg