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Niflumic acid

Product Name
Niflumic acid
CAS No.
4394-00-7
Chemical Name
Niflumic acid
Synonyms
ACTOL;UP-83;sc1332;Forenol;DONALGIN;NIFLURIL;Landruma;niflumic;Niflumate;Niflumicaci
CBNumber
CB3307557
Molecular Formula
C13H9F3N2O2
Formula Weight
282.22
MOL File
4394-00-7.mol
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Niflumic acid Property

Melting point:
203-204 °C
Boiling point:
378.0±42.0 °C(Predicted)
Density 
1.3935 (estimate)
storage temp. 
2-8°C
solubility 
Soluble in ethanol (~50 mg/ml), acetone (50 mg/ml, Clear to Slightly Hazy, Yellow), methanol (~50 mg/ml), DMSO (56 mg/ml at 25°C), and acetonitrile (~50 mg/ml).
pka
pKa 2.26 ± 0.08;4.44± 0.03(H2O,t =25±0.1,I=0.01(NaCl))(Approximate)
form 
Solid
color 
Light orange to Yellow to Green
Water Solubility 
19mg/L(room temperature)
Sensitive 
Light Sensitive
Merck 
14,6531
Stability:
Stable, but may discolour in light. Incompatible with strong oxidizing agents. Hygroscopic.
InChIKey
JZFPYUNJRRFVQU-UHFFFAOYSA-N
NIST Chemistry Reference
Niflumic acid(4394-00-7)
EPA Substance Registry System
3-Pyridinecarboxylic acid, 2-[[3-(trifluoromethyl)phenyl]amino]- (4394-00-7)
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22-36/37/38
Safety Statements 
26-36-36/37/39
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
QT2999100
HazardClass 
6.1
PackingGroup 
HS Code 
29333999
Toxicity
LD50 in rats (mg/kg): 370 orally; 155 i.p. (Sorenson)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
N0630
Product name
Niflumic acid
Packaging
10g
Price
$71.5
Updated
2024/03/01
Sigma-Aldrich
Product number
N0630
Product name
Niflumic acid
Packaging
25g
Price
$160
Updated
2024/03/01
TCI Chemical
Product number
T2353
Product name
2-(3-Trifluoromethylanilino)nicotinic Acid
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$120
Updated
2024/03/01
Alfa Aesar
Product number
J60489
Product name
Niflumic acid, 99+%
Packaging
5g
Price
$47.65
Updated
2024/03/01
Alfa Aesar
Product number
J60489
Product name
Niflumic acid, 99+%
Packaging
10g
Price
$81.9
Updated
2024/03/01
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Niflumic acid Chemical Properties,Usage,Production

Chemical Properties

Crystalline Solid

Originator

Nifluril,U.P.S.A.,France,1968

Uses

analgesic, antiinflammatory

Uses

Niflumic acid is used for the exact same indications as the drugs described above. Synonyms for this drug are actol, flunir, nifluril, and others.

Uses

Anti-inflammatory. Selective cyclooxygenase-2 (COX-2) inhibitor

Definition

ChEBI: Niflumic acid is an aromatic carboxylic acid and a member of pyridines.

Manufacturing Process

Niflumic acid is prepared as follows: Nicotinic acid, m-trifluoromethylaniline, and potassium iodide are intimately mixed and heated on an oil bath at 140°C. The mixture melts to give a dark red liquid. The temperature of the oil bath is allowed to fall to 100°C and is maintained at this temperature for an hour and a half. The mixture puffs up and forms a yellow crystalline mass. After cooling to ordinary temperature, this mass is ground up in a mortar and extracted several times with small volumes of ether to remove excess mtrifluoromethylaniline. The residue is then washed twice with 10 ml of distilled water to remove m-trifluoromethylaniline hydrochloride and potassium iodide, and finally twice with 10 ml of 95% alcohol to remove colored resinous contaminants. After drying at 100°C, 2-(m-trifluoromethylanilino)nicotinic acid is obtained as pale yellow needles (from 70% ethanol) melting at 204°C (Kofler block).

Therapeutic Function

Antiinflammatory

Trade name

Actol (Mayrhofer, Austria; Upsamedica, Spain), Donalgin (Gedeon Richter, Hungary), Livornex (Genepharm, Greece), Ni- flam (Upsamedica, Italy), Nifluril (UPSA, France; Upsamedica, Belgium, Switzerland, Portugal).

Biochem/physiol Actions

Niflumic acid (NFA), a γ-aminobutyric acid type A receptor (GABAARs) antagonist is a non-steroidal anti-inflammatory drug (NSAID) and it belongs to the fenamate class. It is also a blocker of chloride ion channel and a calcium-activated chloride channel (CaCC) inhibitor. NFA possesses anti-inflammatory property and is useful in treating rheumatic disorders. It is also an inhibitor of N-methyl-D-aspartate receptor and glycine receptor. NFA also inhibits enzymes associated with the prostaglandins synthesis.

Side effects

Niflumic acid has been used effectively to treat rheumatoid arthritis, psoriatic arthritis, and hypertrophic osteoarthritis of the hip and knee. Gastric complications are the chief adverse effects of this drug.

Synthesis

Niflumic acid, 2-3-(trifluoromethyl)anilino nicotinic acid (3.2.21), is synthesized either by the reaction of 2-chloronicotinic acid with 3-trifluoromethylaniline [84¨C86], or 2-aminonicotinic acid with 1-bromo-3-trifluoromethylbenzene [87].

Niflumic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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Niflumic acid Suppliers

Tocris Bioscience
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customerservice@tocris.co.uk
Country
United Kingdom
ProdList
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Apin Chemicals Limited (UK)
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info@apinchemicals.com
Country
United Kingdom
ProdList
6184
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Leancare Ltd.
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enquiry@leancare.co.uk
Country
United Kingdom
ProdList
6446
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MOLEKULA Ltd.
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kevinbanks@molekula.com
Country
United Kingdom
ProdList
6140
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CARBONE SCIENTIFIC CO.,LTD
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sales@carbonesci.com
Country
United Kingdom
ProdList
6666
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Eurolabs Limited
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United Kingdom
ProdList
6309
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UK GREEN SCIENTIFIC CO.,LIMITED
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sales@gs-chem.com
Country
United Kingdom
ProdList
6098
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Fluorochem Ltd.
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enquiries@fluorochem.co.uk
Country
United Kingdom
ProdList
6401
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Apin Chemicals Ltd.
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info@apinchemicals.com
Country
United Kingdom
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VWR International
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solutions@vwr.com
Country
United Kingdom
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6548
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View Lastest Price from Niflumic acid manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Niflumic acid 4394-00-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Niflumic acid 4394-00-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09
Career Henan Chemical Co
Product
Niflumic acid 4394-00-7
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
JD 334
Release date
2019-09-01

4394-00-7, Niflumic acidRelated Search:


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  • Nifumic Acid
  • Acidum Nifumicum
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  • 2-3-(Trifluoromethyl)(phenylamino)pyridin-3-carboxylic acid
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  • C15522500 NiflumiCacid
  • 4394-00-7
  • 4934-00-7
  • C13H9F3N2O2
  • C13H8F3N2O2
  • Selective cyclooxygenase-2 (COX-2) inhibitor.
  • Cell Signaling Enzymes
  • Application Index
  • Biochemicals and Reagents
  • BioChemical
  • Cyclooxygenase Inhibitors
  • Cyclooxygenase (COX) Enzymes
  • Enzymes, Inhibitors, and Substrates
  • Aromatics
  • Inhibitors