ChemicalBook > CAS DataBase List > 2-Chloro-4,6-dimethylpyrimidine

2-Chloro-4,6-dimethylpyrimidine

Product Name: 2-Chloro-4,6-dimethylpyrimidine
CAS No.: 4472-44-0
Chemical Name: 2-Chloro-4,6-dimethylpyrimidine
Synonyms: NSC 49016;AKOS BBS-00002114;IFLAB-BB F2130-0005;CHEMBRDG-BB 4900312;2-chloro-4,6-dimethyl-pyrimidin;2-CHLORO-4,6-DIMETHYLPYRIMIDINE;2-Chloro-3,5-dimethylpyrimidine;4,6-DiMethyl-2-chloropyriMidine;2-Chloro-4,6-dimethyl-1,3-diazine;Pyrimidine, 2-chloro-4,6-dimethyl-
CBNumber: CB3311477
Molecular Formula: C6H7ClN2
Formula Weight: 142.59
MOL File: 4472-44-0.mol

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2-Chloro-4,6-dimethylpyrimidine Property

Melting point:: 34-36
Boiling point:: 212 °C
Density: 1,03g/cm
refractive index: 1,428
Flash point:: 110℃
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: Methanol
pka: 0.09±0.30(Predicted)
form: Powder, Crystalline Powder or Low Melting Solid
color: White to yellow
InChIKey: RZVPFDOTMFYQHR-UHFFFAOYSA-N
CAS DataBase Reference: 4472-44-0(CAS DataBase Reference)
NIST Chemistry Reference: 2-Chloro-4,6-dimethylpyrimidine(4472-44-0)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 20/21/22-36/37/38-22
Safety Statements: 26-36-37
RIDADR: UN 2265
RTECS: UV8000000
HazardClass: IRRITANT
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: C2199
Product name: 2-Chloro-4,6-dimethylpyrimidine
Purity: >98.0%(GC)
Packaging: 5g
Price: $44
Updated: 2025/07/31

TCI Chemical

Product number: C2199
Product name: 2-Chloro-4,6-dimethylpyrimidine
Purity: >98.0%(GC)
Packaging: 25g
Price: $178
Updated: 2025/07/31

TRC

Product number: C365445
Product name: 2-Chloro-4,6-dimethylpyrimidine
Packaging: 50g
Price: $240
Updated: 2021/12/16

Usbiological

Product number: 006200
Product name: 2-Chloro-4,6-dimethylpyrimidine
Packaging: 2.5g
Price: $446
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC12088
Product name: 2-Chloro-4,6-dimethylpyrimidine
Packaging: 250g
Price: $250
Updated: 2021/12/16

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2-Chloro-4,6-dimethylpyrimidine Chemical Properties,Usage,Production

Uses

2-Chloro-4,6-dimethylpyrimidine is a chlorinated pyrimidine with antiviral activity.

Synthesis

34289-60-6

4472-44-0

General procedure for the synthesis of 2-chloro-4,6-dimethylpyrimidine from 4,6-dimethyl-2-hydroxypyrimidine hydrochloride: 4,6-dimethyl-2-hydroxypyrimidine hydrochloride (1998 mg, 12.44 mmol) was mixed with phosphorochloridic acid (20 mL) and the reaction was carried out at reflux for 10 hours. Upon completion of the reaction, excess phosphorus trichloride was removed by distillation under reduced pressure to give a brown oil. The reaction mixture was cooled in an ice bath and concentrated aqueous potassium hydroxide solution was added slowly and dropwise to a pH of about 8 (detected by litmus paper). Diethyl ether (30 mL) was then added and stirring was continued for 2.5 hours. The aqueous layer was separated and extracted with ether (3 x 30 mL) and ethyl acetate (3 x 30 mL), respectively. The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The resulting yellow liquid was placed in an ice bath and dried under vacuum to give 2-chloro-4,6-dimethylpyrimidine (1606 mg, 91% yield) as yellow crystals.1H NMR (400 MHz, DMSO-d6) δ 7.33 (s, 1H), 2.42 (s, 6H).

References

[1] PLoS ONE, 2018, vol. 13, # 1,
[2] Journal of Organic Chemistry, 2002, vol. 67, # 18, p. 6550 - 6552
[3] Phosphorus, Sulfur and Silicon and the Related Elements, 2008, vol. 183, # 4, p. 986 - 991
[4] Journal of Organometallic Chemistry, 2013, vol. 732, p. 137 - 141

2-Chloro-4,6-dimethylpyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

N-(4,6-DIMETHYLPYRIMIDIN-2-YL)-N-ETHYLBENZENE-1,4-DIAMINE N-(4,6-DIMETHYLPYRIMIDIN-2-YL)-N-METHYLBENZENE-1,4-DIAMINE N-(4,6-DIMETHYLPYRIMIDIN-2-YL)BENZENE-1,4-DIAMINE PYRIMIDINE-4,6-DICARBOYL DICHLORIDE N-(4-NITROPHENYL)-4,6-DIMETHYL-2-PYRIMIDINAMINE

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2-Chloro-4,6-dimethylpyrimidine Suppliers

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View Lastest Price from 2-Chloro-4,6-dimethylpyrimidine manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 2-Chloro-4,6-dimethylpyrimidine 4472-44-0
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 5000
Release date: 2024-11-12

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: 2-Chloro-4,6-dimethylpyrimidine 4472-44-0
Price: US $3.90/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2021-09-24

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: 2-Chloro-4,6-dimethylpyrimidine 4472-44-0
Price: US $3.90/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 10KG
Release date: 2021-09-24

4472-44-0, 2-Chloro-4,6-dimethylpyrimidineRelated Search:

2-Chloropyrimidine N,N-Dimethylformamide tert-Butyldimethylsilyl chloride Dimethyl sulfoxide Chlorodimethylphenylsilane DIMETHYLTHEXYLSILYL CHLORIDE Poly(dimethylsiloxane) CHLORODIMETHYLVINYLSILANE Difluorochloromethane METHYL 2-CHLORO-6-METHYLPYRIMIDINE-4-CARBOXYLATE 6-CHLORO-1,3-DIMETHYLPYRIMIDINE-2,6-1H,3H-DIONE,6-Chloro-1,3-dimethylpyrimidine-2,4-dione,6-CHLORO-1,3-DIMETHYLPYRIMIDINE-2,4(1H,3H)-DIONE 4-Chloro-2,6-dimethylpyrimidine95%,4-CHLORO-2,6-DIMETHYLPYRIMIDINE,4-CHLORO-2,6-DIMETHYLPYRIMIDINE 95%,6-Chloro-2,4-dimethylpyrimidine 4-AMINO-2-CHLORO-6,7-DIMETHYLPYRIMIDINE,4-AMINO-5-CHLORO-2,6-DIMETHYLPYRIMIDINE 5-Bromo-2-chloro-4-(dimethylamino)pyrimidine 4,6-Dichloro-2,5-Dimethyl Pyrimidine 4,6-DIMETHYLPYRIMIDINE ETHYL 2-CHLORO-6-METHYLPYRIMIDINE-4-CARBOXYLATE 2-Chloro-4,6-diphenylpyrimidine

CHEMBRDG-BB 4900312

IFLAB-BB F2130-0005

2-CHLORO-4,6-DIMETHYLPYRIMIDINE

2-chloro-4,6-dimethyl-pyrimidin

Pyrimidine, 2-chloro-4,6-dimethyl-

AKOS BBS-00002114

Pyrimidine, 2-chloro-4,6-dimethyl- (6CI,7CI,8CI,9CI)

2-CHLORO-4,6-DIMETHYLPYRIMIDINE,98.0+%(GC)

2-Chloro-3,5-dimethylpyrimidine

2-chloro-4,6-dimethylpyrimidine(SALTDATA: FREE)

2-Chloro-4,6-dimethyl-1,3-diazine

2-Chloro-4,6-diMethylpyriMidine, 98%+

4,6-DiMethyl-2-chloropyriMidine

NSC 49016

JR-8782, 2-Chloro-4,6-dimethylpyrimidine, 97%

2-Chloro-4,6-dimethylpyrimidine &gt

2-Chloro-4,6-dimethylpyrimidine ISO 9001：2015 REACH

4472-44-0

C6H7ClN2

HETERO CHLORIDE

Pyrazines, Pyrimidines & Pyridazines

Heterocycle-Pyrimidine series

PYRIMIDINE

pharmacetical

Halides

Pyrazines, Pyrimidines & Pyridazines