4-Morpholinobenzaldehyde
- Product Name
- 4-Morpholinobenzaldehyde
- CAS No.
- 1204-86-0
- Chemical Name
- 4-Morpholinobenzaldehyde
- Synonyms
- 4-MORPHOLINOBENZENECARBALDEHYDE;4-(4-FORMYLPHENYL)MORPHOLINE;4-MORPHOLIN-4-YL-BENZALDEHYDE;4-(4-MORPHOLINYL)BENZALDEHYDE;AKOS BC-2976;AKOS BBS-00004794;BUTTPARK 98\50-29;IFLAB-BB F1274-0239;TIMTEC-BB SBB000299;SALOR-INT L481084-1EA
- CBNumber
- CB3312111
- Molecular Formula
- C11H13NO2
- Formula Weight
- 191.23
- MOL File
- 1204-86-0.mol
4-Morpholinobenzaldehyde Property
- Melting point:
- 65-69 °C
- Boiling point:
- 365.5±37.0 °C(Predicted)
- Density
- 1.163±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 1.87±0.40(Predicted)
- color
- Light yellow to Yellow to Orange
- CAS DataBase Reference
- 1204-86-0(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39-24/25
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29349990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H226Flammable liquid and vapour
H302Harmful if swallowed
H315Causes skin irritation
H317May cause an allergic skin reaction
H318Causes serious eye damage
H331Toxic if inhaled
H341Suspected of causing genetic defects
H351Suspected of causing cancer
H361Suspected of damaging fertility or the unborn child
H370Causes damage to organs
H372Causes damage to organs through prolonged or repeated exposure
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P272Contaminated work clothing should not be allowed out of the workplace.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 678813
- Product name
- 4-(4-Morpholinyl)benzaldehyde
- Purity
- 97%
- Packaging
- 5g
- Price
- $113
- Updated
- 2025/07/31
- Product number
- M1625
- Product name
- 4-(4-Formylphenyl)morpholine
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $28
- Updated
- 2025/07/31
- Product number
- M1625
- Product name
- 4-(4-Formylphenyl)morpholine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $71
- Updated
- 2025/07/31
- Product number
- M1625
- Product name
- 4-(4-Formylphenyl)morpholine
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $239
- Updated
- 2025/07/31
- Product number
- M725280
- Product name
- 4-Morpholin-4-yl-benzaldehyde
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
4-Morpholinobenzaldehyde Chemical Properties,Usage,Production
Uses
4-Morpholinobenzaldehyde is mainly used as a raw material for organic synthesis. It can be used to prepare dihydrotetrazolopyrimidine derivatives (ethyl 5-methyl-7-(4-morpholinophenyl)-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate), coumarin-based chalcone derivatives ((E)-3-[3-(4-(4-morpholinophenyl)acryloyl]-2H-chromen-2-one) and Ru(II) polypyridine complexes, among others.
Synthesis
110-91-8
459-57-4
1204-86-0
General procedure for the synthesis of 4-(4-morpholine)benzaldehyde from morpholine and p-fluorobenzaldehyde: In a dry reaction flask, p-fluorobenzaldehyde (25.0 g, 0.200 mol), morpholine (0.300 mol), and anhydrous potassium carbonate (40.0 g) were dissolved in N,N-dimethylformamide (DMF, 300 mL), and a catalytic amount of Aliquat 336 reagent. The reaction mixture was stirred at reflux for 24 hours at 100°C. Upon completion of the reaction, the mixture was concentrated to dryness under reduced pressure and cooled to room temperature. Subsequently, the concentrate was slowly poured into ice water and allowed to stand overnight. The precipitated solid was collected by filtration, washed with water and recrystallized with methanol to afford the target compound 4-morpholino benzaldehyde (Id) in 89% yield as yellow crystals with a melting point of 69 °C (in agreement with literature reports) [49,50].
References
[1] Journal of Medicinal Chemistry, 2016, vol. 59, # 6, p. 2747 - 2759
[2] Bioorganic Chemistry, 2014, vol. 57, p. 65 - 82
[3] European Journal of Medicinal Chemistry, 2018, vol. 144, p. 68 - 81
[4] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 12, p. 3721 - 3725
[5] Russian Journal of General Chemistry, 2013, vol. 83, # 10, p. 1864 - 1868
4-Morpholinobenzaldehyde Preparation Products And Raw materials
Raw materials
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View Lastest Price from 4-Morpholinobenzaldehyde manufacturers
- Product
- 4-Morpholinobenzaldehyde 1204-86-0
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2020-01-09