2,2-DIMETHYL-PIPERAZINE
- Product Name
- 2,2-DIMETHYL-PIPERAZINE
- CAS No.
- 84477-72-5
- Chemical Name
- 2,2-DIMETHYL-PIPERAZINE
- Synonyms
- 2-dimethylpiperazine;2,2-DIMETHYL-PIPERAZINE;Piperazine, 2,2-dimethyl-;cis-2,2-dimethylpiperazine;2,2-DiMethyl-piperazine 2HCl;2,2-DIMETHYL-PIPERAZINE ISO 9001：2015 REACH
- CBNumber
- CB3312131
- Molecular Formula
- C6H14N2
- Formula Weight
- 114.19
- MOL File
- 84477-72-5.mol
2,2-DIMETHYL-PIPERAZINE Property
- Boiling point:
- 155.2±8.0 °C(Predicted)
- Density
- 0.833±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- 9.38±0.40(Predicted)
- form
- Solid
- color
- Pale Yellow Low Melting
- InChI
- InChI=1S/C6H14N2/c1-6(2)5-7-3-4-8-6/h7-8H,3-5H2,1-2H3
- InChIKey
- PIPWSBOFSUJCCO-UHFFFAOYSA-N
- SMILES
- N1CCNCC1(C)C
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D457210
- Product name
- 2,2-Dimethylpiperazine
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FD51184
- Product name
- 2,2-Dimethyl-piperazine
- Packaging
- 500mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- FD51184
- Product name
- 2,2-Dimethyl-piperazine
- Packaging
- 1g
- Price
- $150
- Updated
- 2021/12/16
- Product number
- FD51184
- Product name
- 2,2-Dimethyl-piperazine
- Packaging
- 2g
- Price
- $250
- Updated
- 2021/12/16
- Product number
- J53533
- Product name
- 2,2-Dimethylpiperazine
- Packaging
- 10g
- Price
- $295
- Updated
- 2021/12/16
2,2-DIMETHYL-PIPERAZINE Chemical Properties,Usage,Production
Uses
2,2-Dimethylpiperazine is a chemical reagent used in the preparation of non-covalent NAAA inhibitors used as a protective agent for the development of multiple sclerosis.
Synthesis
22476-74-0
84477-72-5
Example 4 Synthesis of 2,2-dimethylpiperazine: 3,3-dimethylpiperazin-2-one (8.28 kg, 64.6 mol) was mixed with tetrahydrofuran (THF, 60 kg) and heated to 50-60 °C to form a slightly turbid solution. LiAlH4 (250 g, encapsulated in a soluble plastic bag) was slowly added to the stirring THF (50 kg) under nitrogen protection and a slow gas release was observed. After the gas release ceased, the addition of LiAlH4 (total 3.0 kg, 79.1 mol) was continued and the reaction was exothermic causing the temperature to rise from 22°C to 50°C. Subsequently, a solution of 3,3-dimethylpiperazin-2-one was added slowly and dropwise over a period of 2 h at 41-59 °C. The solution was then added to the suspension over a period of 2 h. The solution was then added to the suspension over a period of 1 h at 41-59 °C. After addition, the suspension was continued to be stirred at 59 °C (jacket temperature 60 °C) for 1 hour. After the reaction mixture was cooled, water (3 L) was added slowly over a period of 2 h. The temperature was controlled to be lower than 25 °C (cooling by EPO, jacket temperature 0 °C). Next, 15% aqueous sodium hydroxide solution (3.50 kg) was added over 20 min at 23 °C and cooled if necessary. Subsequently, water (9 L) was added within half an hour, cooling was required to maintain the temperature, and the mixture was stirred overnight under nitrogen protection. Celite filter (4 kg) was added, the mixture was filtered and the filter cake was washed with THF (40 kg). The filtrates were combined and concentrated in a reactor until the temperature in the reactor reached 70 °C (distillation temperature 66 °C, pressure 800 mbar). The residue (12.8 kg) was further concentrated by rotary evaporator to about 10 L. Finally, the mixture was fractionated at atmospheric pressure and the 163-164 °C fraction was collected to give 5.3 kg of product (72% yield). The structure of the product was confirmed by NMR.
References
[1] Patent: WO2005/16900, 2005, A1. Location in patent: Page/Page column 27-28
[2] Patent: WO2006/86986, 2006, A1. Location in patent: Page/Page column 15
[3] Patent: WO2006/86985, 2006, A1. Location in patent: Page/Page column 14-15
[4] Patent: WO2006/86984, 2006, A1. Location in patent: Page/Page column 20
[5] Patent: WO2015/38417, 2015, A1. Location in patent: Page/Page column 113; 114
2,2-DIMETHYL-PIPERAZINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,2-DIMETHYL-PIPERAZINE manufacturers
- Product
- 2,2-Dimethylpiperazine 84477-72-5
- Price
- US $2.90/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 10KG
- Release date
- 2021-09-24
- Product
- 2,2-Dimethylpiperazine 84477-72-5
- Price
- US $2.90/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2021-11-26
- Product
- 2,2-DIMETHYL-PIPERAZINE 84477-72-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons
- Release date
- 2022-02-24