ChemicalBook > CAS DataBase List > 2-Pyridinecarbothioamide, N-2-pyridinyl-

2-Pyridinecarbothioamide, N-2-pyridinyl-

Product Name: 2-Pyridinecarbothioamide, N-2-pyridinyl-
CAS No.: 39122-38-8
Chemical Name: 2-Pyridinecarbothioamide, N-2-pyridinyl-
Synonyms: NSC 185058;2-Pyridinecarbothioamide, N-2-pyridinyl-;N-(Pyridin-2-yl)pyridine-2-carbothioamide;Inhibitor,NSC-185058,Atg4,NSC 185058,Autophagy,Autophagy-related 4,inhibit
CBNumber: CB33207720
Molecular Formula: C11H9N3S
Formula Weight: 215.27
MOL File: 39122-38-8.mol

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2-Pyridinecarbothioamide, N-2-pyridinyl- Property

Melting point:: 82 °C(Solv: ethanol, 70% (64-17-5))
Boiling point:: 378.2±40.0 °C(Predicted)
Density: 1.323±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 2.5 mg/ml
form: A crystalline solid
pka: 8.76±0.70(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 23957
Product name: NSC 185058
Purity: ≥98%
Packaging: 1mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 23957
Product name: NSC 185058
Purity: ≥98%
Packaging: 5mg
Price: $249
Updated: 2024/03/01

TRC

Product number: B488988
Product name: N-(pyridin-2-yl)pyridine-2-carbothioamide
Packaging: 10mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B488988
Product name: N-(pyridin-2-yl)pyridine-2-carbothioamide
Packaging: 100mg
Price: $220
Updated: 2021/12/16

AK Scientific

Product number: 5078CD
Product name: 2-Pyridinecarbothioamide,N-2-pyridinyl-
Packaging: 100mg
Price: $290
Updated: 2021/12/16

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2-Pyridinecarbothioamide, N-2-pyridinyl- Chemical Properties,Usage,Production

Uses

NSC 185058 is an inhibitor of ATG4B, a major cysteine protease. Inhibition of ATG4B using NSC 185058 markedly attenuates autophagic activity[1].

in vivo

NSC185058 is an ATG4B antagonist. ATG4B stimulates autophagy by promoting autophagosome formation through reversible modification of ATG8. Inclusion of the ATG4B inhibitor NSC185058 enhances the anti-tumor activity of radiation therapy (RT). NSC185058 decreases glioblastoma (GBM) cell tumorigenicity, and enhances the anti-tumor activity of RT when applied to orthotopic GBM xenograft models^[1].

References

[1] Huang T, et al. MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma. Cancer Cell. 2017 Dec 11;32(6):840-855.e8. DOI:10.1016/j.ccell.2017.11.005

2-Pyridinecarbothioamide, N-2-pyridinyl- Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Pyridinecarbothioamide, N-2-pyridinyl-

NSC 185058

N-(Pyridin-2-yl)pyridine-2-carbothioamide

Inhibitor,NSC-185058,Atg4,NSC 185058,Autophagy,Autophagy-related 4,inhibit

39122-38-8