2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methylthio-1H-benzimidazole

Product Name: 2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methylthio-1H-benzimidazole
CAS No.: 103577-40-8
Chemical Name: 2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methylthio-1H-benzimidazole
Synonyms: LANSOPRAZOLE SULFIDE;lansoprazole sulphide;K 1252;AG 1777;H 225/18;EC 600-451-9;Lansoprazole-3;2-[3-Methyl-4-(2;2-[3-Methyl-4-(2,2,2;Lansoprazole impurity C
CBNumber: CB3331554
Molecular Formula: C16H14F3N3OS
Formula Weight: 353.36
MOL File: 103577-40-8.mol

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2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methylthio-1H-benzimidazole Property

Melting point:: 149-150°C
Boiling point:: 494.9±55.0 °C(Predicted)
Density: 1.41
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 10.60±0.10(Predicted)
form: Crystalline Powder
color: White to Pale Orange
λmax: 292nm(EtOH)(lit.)
InChI: InChI=1S/C16H14F3N3OS/c1-10-13(20-7-6-14(10)23-9-16(17,18)19)8-24-15-21-11-4-2-3-5-12(11)22-15/h2-7H,8-9H2,1H3,(H,21,22)
InChIKey: CCHLMSUZHFPSFC-UHFFFAOYSA-N
SMILES: C1(SCC2=NC=CC(OCC(F)(F)F)=C2C)NC2=CC=CC=C2N=1
CAS DataBase Reference: 103577-40-8(CAS DataBase Reference)

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Safety

Safety Statements: 24/25
HS Code: 29309090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical

Product number: M2800
Product name: 2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridylmethylthio]benzimidazole
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $61
Updated: 2025/07/31

TCI Chemical

Product number: M2800
Product name: 2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridylmethylthio]benzimidazole
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $299
Updated: 2025/07/31

TRC

Product number: L175020
Product name: LansoprazoleSulfide
Packaging: 50mg
Price: $80
Updated: 2021/12/16

TRC

Product number: L175020
Product name: LansoprazoleSulfide
Packaging: 500mg
Price: $600
Updated: 2021/12/16

Usbiological

Product number: L1277-02
Product name: Lansoprazole Sulfide
Packaging: 100mg
Price: $403
Updated: 2021/12/16

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2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methylthio-1H-benzimidazole Chemical Properties,Usage,Production

Chemical Properties

Pale Yellow Solid

Uses

Lansoprazole Sulfide (Lansoprazole EP Impurity C; USP Impurity B) is a metabolite of Lansoprazole, as gastric pump inhibitor.

Synthesis

128430-66-0

134469-07-1

103577-40-8

2-Chloromethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine (91 g, 0.38 mol) and 1H-benzo[d]imidazole-2-thiol (57 g, 0.38 mol) were used as raw materials, suspended in methanol (1 L), and benzyltributylammonium bromide (2.15 g) was added as a phase transfer catalyst. A 30% NaOH solution (65 mL) was added slowly and dropwise over a period of 1 h, followed by stirring the reaction for 2 h at room temperature. Upon completion of the reaction, water (300 mL) was added to the reaction mixture and stirring was continued for 30 min. The mixture was cooled to 10 °C and the pH was adjusted to 9 with 35% HCl, at which point the target product 2-(((3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole precipitated as a precipitate. The precipitate was collected by filtration and washed sequentially with 50% methanol and water. Finally, the product was dried under vacuum at 50 °C to give 129 g in 96% yield.

References

[1] Organic Process Research and Development, 2013, vol. 17, # 10, p. 1272 - 1276
[2] Patent: CN106543146, 2017, A. Location in patent: Paragraph 0025; 0031; 0032; 0041; 0045; 0049; 0053-0069
[3] Synthetic Communications, 2002, vol. 32, # 8, p. 1211 - 1217

2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methylthio-1H-benzimidazole Preparation Products And Raw materials

Raw materials

Preparation Products

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2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methylthio-1H-benzimidazole Suppliers

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View Lastest Price from 2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methylthio-1H-benzimidazole manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methylthio-1H-benzimidazole 103577-40-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-20

Henan Fengda Chemical Co., Ltd

Product: 2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methylthio-1H-benzimidazole 103577-40-8
Price: US $8.00-1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-08

Qiuxian Baitai New Material Co., LTD

Product: Lansoprazole sulfide 103577-40-8
Price: US $70.00/KG
Min. Order: 100KG
Purity: 99%
Supply Ability: 5ton/Month
Release date: 2021-11-24

103577-40-8, 2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methylthio-1H-benzimidazoleRelated Search:

Kresoxim-methyl Methyl acetate Methyl salicylate METSULFURON METHYL 5-Amino-2-methylpyridine 4-Methylpyridine Ethoxymethylenemalononitrile Benzimidazole ISOMETHIOZIN 2-Chloro-5-chloromethylpyridine Azamethiphos Tribenuron methyl 2,6-Lutidine 2-Hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine hydrochloride Thiophanate-methyl Methyl 4-Nitro-2,3-lutidine-N-oxide 2-Chloromethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine hydrochloride

2-[[3-Methyl-4-(2,2,2-trifluoroethoxy)pyridine-2-yl]methylthio]-1H-benzoimidazole

2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinylmethylthio]-1H-benzoimidazole

2-[3-Methyl-4-(2,2,2

Lansoprazole Related Compound B (25 mg) (2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-pyridin-2-yl]methyl]sulfanyl]-1H-benzimidazole)

2-{[3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]Methyl}-1H-1,3-benzodiazole-1-thiol

2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)Methyl)thio)-1H-benzo[d]iMidazole

2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]Methyl]thio]-

1H-BenziMidazole, 2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]Methyl]thio]-

2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]Methyl thio-1H-benziMidazole hydrate

2-(((3-METHYL-4(2,2,2-TRIFLUROETHOXY)-2-PYRIDINYL)METHYL)SULFANYL)-1H-BENZIMIDAZOLE

Lansoprazole IMpurity-Sulfide (EP-IMpurity C)

Lansoprazole EP IMpurity C

Lansoprazole Related CoMpound B

Lansoprazole related substance C

1-(methylthio)-2-[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]benzimidazole

Imp. B (EP):2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methyl]sulphonyl]-1Hbenzimidazole(Lansoprazole Sulphone)

Lansoprazole impurity 3/Lansoprazole EP Impurity C/Lansoprazole Sulfide/2-(((3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole

Lansoprazole-3

2-(((3-methyl-4-(2,2,2-trifluoroethoxy)

Lansoprazole impurity C

lansoprazole sulphide

2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridylmethylthio]benzimidazole

LANSOPRAZOLE SULFIDE

2-[3-METHYL-4-(2,2,2-TRIFLUOROETHOXY)-2-PYRIDINYL]METHYL THIO-1H-BENZIMIDAZOLE

2-[[3-METHYL-4-(2,2,2-TRIFLUOROETHOXY)PYRID-2YL]METHYLTHIO]BENZIMIDAZOLE

2-((METHYL-4-(2,2,2-TRIFLUOROETHOXY)PYRIDINYL)THIO)-1H-BINZIMIDAZOLE

2-[[[3 methyl-4-(2,2,2 trifluoroethoxy) 2-pyridyl]-methyl] thio]-1H-benzimidazole

2-[[(3-Methyl-4-(2,2,2-Trifluoroethoxy) Pyridinyl) Methyl] Thio]-1H-Benzimidazole

2-[[[3-Methyl-4-(2,2,2-Trifluoroethyoxy)-2-Pyridyl]-Methyl]Thio]-1H-Benzimidazole

2-[3-Methyl-4-(2,2,2-Trifluoroethoxy)Methylthio-1H-Benzimidazole

2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)pyridinyl)thio)-(1H)-binzimidazole

AG 1777

H 225/18

K 1252

Lansoprazole sulphide compound

2-[3-METHYL-4-(2,2,2-TRIFLUOROETHOXY)-2-PYRIDINYL ]METHYL THIO-1H-BENZIMIDAZOLE 98+%

2-[(1H-Benzoimidazole-2-yl)thiomethyl]-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine

Lansoprazole EP Impurity C/USP Impurity B

2-[3-Methyl-4-(2

2-trifluoroethoxy)-2-pyridinyl]methylthio-1H-benzimidazole

Lansoprazole EP Impurity C (Lansoprazole USP Related Compound B)

Lansoprazole Impurity 3(Lansoprazole EP Impurity C)

Lansoprazole EP Impurity C (Lansoprazole Sulfide)

lansoprazole Sulfur ether

Dexlansoprazole Impurity 9

2-[[[3-Methyl-4-(2,2,2-trifluoromethoxy)pyrid-2-yl]methyl]thio]benzimidazole

LANSOPRAZOLE INTERMEDIATES

Dex-Lansoprazole Sulfide/Lansoprazole EP Impurity C

Lansoprazole USP Impurity B

Lansoprazole EP Impurity C (Sulphide)

Lansoprazole EP Impurity C/ Lansoprazole Related Compound B (Lansoprazole Sulfide)

2-[[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methylsulfanyl]-1H-benzimidazole

2-[[[3 methyl-4-(2,2,2 trifluoroethoxy) 2-pyridyl]-methyl] t...

Lansoprazole Sulfide ImpurityQ: What is Lansoprazole Sulfide Impurity Q: What is the CAS Number of Lansoprazole Sulfide Impurity Q: What is the storage condition of Lansoprazole Sulfide Impurity

Lansoprazole Related Compound B (2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-pyridin-2-yl]methyl]sulfan (1356931)

Lansoprazole Impurity C（EP）

2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridiny]methylthio-1H- benzimidazole

EC 600-451-9