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2'-(Trifluoromethyl)acetophenone

Product Name
2'-(Trifluoromethyl)acetophenone
CAS No.
17408-14-9
Chemical Name
2'-(Trifluoromethyl)acetophenone
Synonyms
2-ACETYLBENZOFLUORIDE;2-ACETYLBENZOTRIFLUORIDE;2-(trifluoromethyl) hypnone;O-TRIFLUOROMETHYLACETOPHENONE;2-(TRIFLUOROMETHYL)ACETOPHENONE;2'-(trifluoromethyl)acetophenone;Acetophenone, 2'-trifluoromethyl-;2'-(Trifluoromethyl)acetophenone98%;2'-(Trifluoromethyl)acetophenone 98%;2'-(Trifluoromethyl)acetophenone,99%
CBNumber
CB3341401
Molecular Formula
C9H7F3O
Formula Weight
188.15
MOL File
17408-14-9.mol
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2'-(Trifluoromethyl)acetophenone Property

Melting point:
15-17°C
Boiling point:
163 °C
Density 
1.255 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.4584(lit.)
Flash point:
184 °F
storage temp. 
2-8°C
form 
Liquid
Specific Gravity
1.255
color 
Clear colorless to very slightly yellow
BRN 
2259035
CAS DataBase Reference
17408-14-9(CAS DataBase Reference)
NIST Chemistry Reference
2'-(Trifluoromethyl)acetophenone(17408-14-9)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37/39-24/25-36
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29143990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
233153
Product name
2′-(Trifluoromethyl)acetophenone
Purity
99%
Packaging
5g
Price
$20.44
Updated
2025/07/31
TCI Chemical
Product number
T1899
Product name
2'-(Trifluoromethyl)acetophenone
Purity
>98.0%(GC)
Packaging
5g
Price
$58
Updated
2025/07/31
TRC
Product number
T797173
Product name
2''-(Trifluoromethyl)acetophenone
Packaging
50mg
Price
$45
Updated
2021/12/16
Apolloscientific
Product number
PC7470
Product name
2'-(Trifluoromethyl)acetophenone
Purity
98%
Packaging
25g
Price
$50
Updated
2021/12/16
Matrix Scientific
Product number
006491
Product name
2'-(Trifluoromethyl)acetophenone
Purity
99%
Packaging
25g
Price
$50
Updated
2021/12/16
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2'-(Trifluoromethyl)acetophenone Chemical Properties,Usage,Production

Chemical Properties

clear colorless to very slightly yellow liqui

Uses

2′-(Trifluoromethyl)acetophenone has been used to investigate the use of in situ generated CuCF3 for the direct substitution of chlorine by CF3 in various aromatic substrates.

Synthesis

79756-81-3

17408-14-9

The general procedure for the synthesis of o-trifluoromethylacetophenone using 1-(2-trifluoromethylphenyl)ethanol as starting material was as follows: in a round-bottomed flask, which was pre-dried in an oven, eosin Y (5 mmol), 1-(2-trifluoromethylphenyl)ethanol (1 mmol), and 3 equiv. of TBHP (5.5 M solution in decane, with the solvent being dry acetonitrile (ACN) were added. The resulting mixture was degassed for 15 min and subsequently backfilled with nitrogen. Next, the mixture was irradiated at room temperature (25 °C) using a blue LED lamp (12 W, 455 nm). The progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the mixture was diluted with 15 mL of 10% NaHCO3 solution and extracted with ethyl acetate (EtOAc, 3 × 20 mL). The organic extracts were combined, washed with brine (20 mL), dried over anhydrous sodium sulfate (Na2SO4) and subsequently concentrated under vacuum. Finally, the crude product was purified by silica gel column chromatography using ethyl acetate:hexane as eluent to obtain the target product o-trifluoromethyl acetophenone.

References

[1] ChemCatChem, 2015, vol. 7, # 12, p. 1865 - 1870
[2] Tetrahedron Letters, 2016, vol. 57, # 30, p. 3294 - 3297
[3] Green Chemistry, 2017, vol. 19, # 2, p. 474 - 480

2'-(Trifluoromethyl)acetophenone Preparation Products And Raw materials

Raw materials

Preparation Products

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2'-(Trifluoromethyl)acetophenone Suppliers

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View Lastest Price from 2'-(Trifluoromethyl)acetophenone manufacturers

Hebei Yanxi Chemical Co., Ltd.
Product
2'-(Trifluoromethyl)acetophenone 17408-14-9
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20tons
Release date
2023-10-09
Zhuozhou Wenxi import and Export Co., Ltd
Product
2"-(Trifluoromethyl)acetophenone 17408-14-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27
Career Henan Chemical Co
Product
2'-(Trifluoromethyl)acetophenone 17408-14-9
Price
US $1.00/KG
Min. Order
1KG
Purity
98%-100%
Supply Ability
1
Release date
2018-08-12

17408-14-9, 2'-(Trifluoromethyl)acetophenoneRelated Search:

4'-Methylacetophenone 2'-Hydroxyacetophenone Benzotrifluoride Trifluoroacetophenone 2-Aminoacetophenone 3'-Methylacetophenone 4-Aminobenzotrifluoride (Trifluoromethyl)trimethylsilane Lithium trifluoromethanesulfonate 4-Fluoroacetophenone Trifluoromethanesulfonic acid Acetophenone 2-(TRIFLUOROMETHOXY)BENZALDEHYDE alpha,alpha,alpha-Trifluoro-o-cresol 2-Trifluoromethylphenylboronic acid METHYL 2-(TRIFLUOROMETHOXY)BENZOATE 2-Trifluoromethoxyphenol 2-(Trifluoromethyl)benzoic acid

  • 2-ACETYLBENZOFLUORIDE
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  • 2′-(Trifluoromethyl)acetophenone, CAS 17408-14-9
  • 17408-14-9
  • C9H7OF3
  • C9H7F3O
  • C9H7F30
  • Ketones
  • Organic Building Blocks
  • KETONE
  • Building Blocks
  • Carbonyl Compounds
  • C9
  • Fluorine series
  • Benzenes
  • C9
  • Carbonyl Compounds
  • Ketones
  • Aromatic Acetophenones & Derivatives (substituted)
  • Boronic Acid series
  • Fluorobenzene
  • Carbonyl Compounds