ChemicalBook > CAS DataBase List > H-8 DIHYDROCHLORIDE

H-8 DIHYDROCHLORIDE

Product Name
H-8 DIHYDROCHLORIDE
CAS No.
113276-94-1
Chemical Name
H-8 DIHYDROCHLORIDE
Synonyms
H-8;H-8 HYDROCHLORIDE;H-8 DIHYDROCHLORIDE;H-8 dihydrochloride,98%;H8, dihydrochloride salt;H-8 dihydrochloride >98% (HPLC);H8 (hydrochloride),H 8 (hydrochloride);H-8 DIHYDROCHLORIDE POTENT INHIBITOR OF C;N-[2-(methylamino)ethyl]isoquinoline-5-sulfonamide;2-(5-isoquinolinylsulfonylamino)ethyl-methylammonium
CBNumber
CB3341825
Molecular Formula
C12H17Cl2N3O2S
Formula Weight
338.25
MOL File
113276-94-1.mol
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H-8 DIHYDROCHLORIDE Property

Melting point:
221-222℃ (methanol water )
storage temp. 
2-8°C
solubility 
ethanol: 25 mg/mL, clear, colorless
form 
Lyophilized
color 
White to Off-White
Water Solubility 
water: 10mg/mL
InChI
InChI=1S/C12H15N3O2S.2ClH/c1-13-7-8-15-18(16,17)12-4-2-3-10-9-14-6-5-11(10)12;;/h2-6,9,13,15H,7-8H2,1H3;2*1H
InChIKey
RJJLZYZEVNCZIW-UHFFFAOYSA-N
SMILES
C12=CC=NC=C1C=CC=C2S(=O)(=O)NCCNC.Cl.Cl
CAS DataBase Reference
113276-94-1(CAS DataBase Reference)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
HS Code 
29334990
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M9656
Product name
H-8 dihydrochloride
Purity
>98% (HPLC)
Packaging
5mg
Price
$160
Updated
2025/07/31
Sigma-Aldrich
Product number
371958
Product name
H-8 dihydrochloride
Packaging
1mg
Price
$167
Updated
2023/01/07
Cayman Chemical
Product number
10010249
Product name
H-8 (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
10010249
Product name
H-8 (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$59
Updated
2024/03/01
Cayman Chemical
Product number
10010249
Product name
H-8 (hydrochloride)
Purity
≥98%
Packaging
25mg
Price
$116
Updated
2024/03/01
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H-8 DIHYDROCHLORIDE Chemical Properties,Usage,Production

Description

The H series isoquinolinesulfonamide protein kinase (PK) inhibitors are widely used to block signaling pathways to elucidate mechanisms of cellular regulation and signal transduction. H-8, an isoquinolinesulfonamide protein kinase (PK) inhibitor, is a potent inhibitor of PKA and PKG and shows moderate inhibition for PKC and MLCK with Ki values of 1.2, 0.48, 15, and 68 μM, respectively. H-8 can disrupt transcriptional elongation by inhibiting cyclin C/Cdk8 and cyclin H/Cdk7/p36 CTD kinase activity with IC50 values of 47 and 6.2 μM, respectively.

Chemical Properties

white to off-white crystalline solid

Uses

Active inhibitor of cyclic-nucleotide-dependent protein kinases.

Biochem/physiol Actions

cAMP and cGMP-dependent protein kinase inhibitor.

References

[1] R A ENGH. Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity.[J]. The Journal of Biological Chemistry, 1996, 271 42: 26157-26164. DOI: 10.1074/jbc.271.42.26157
[2] HIROYOSHI HIDAKA. Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide-dependent protein kinase and protein kinase C[J]. Biochemistry Biochemistry, 1984, 23 21: 5036-5041. DOI: 10.1021/bi00316a032
[3] M HAGIWARA  H H  M Inagaki. Specific binding of a novel compound, N-[2-(methylamino)ethyl]-5-isoquinolinesulfonamide (H-8) to the active site of cAMP-dependent protein kinase.[J]. Molecular Pharmacology, 1987, 31 5: 523-528.
[4] P RICKERT  E L  J L Corden. Cyclin C/CDK8 and cyclin H/CDK7/p36 are biochemically distinct CTD kinases.[J]. Oncogene, 1999, 18 4: 1093-1102. DOI: 10.1038/sj.onc.1202399

H-8 DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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H-8 DIHYDROCHLORIDE Suppliers

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113276-94-1, H-8 DIHYDROCHLORIDERelated Search:

N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE 1-(5-ISOQUINOLINESULFONYL)PIPERAZINE, DIHYDROCHLORIDE FASUDIL 1,4-BIS[3-(3,4,5-TRIMETHOXYBENZOYLOXY)PROPYL]HOMOPIPERAZINE DIHYDROCHLORIDE 1,3-PHENYLENEDIAMINE DIHYDROCHLORIDE 1,4'-BIPIPERIDINE DIHYDROCHLORIDE,[1,4']BIPIPERIDINYL DIHYDROCHLORIDE 1-(3-TRIFLUOROMETHYL-PHENYL)-PIPERAZINE DIHYDROCHLORIDE 1-(4-Bromophenyl)piperazine 1,4-BUTANEDIAMINE DIHYDROCHLORIDE 1-(3-METHOXYPHENYL)PIPERAZINE DIHYDROCHLORIDE 1,3-PROPANEDIAMINE DIHYDROCHLORIDE 1-(3-METHYLPHENYL)PIPERAZINE DIHYDROCHLORIDE HYDRATE,1-(3-Methylphenyl)piperazine dihydrochloride 10-[3-(4-METHYL-1-PIPERAZINYL)PROPYL]-2-TRIFLUOROMETHYL-PHENOTHIAZINE DIHYDROCHLORIDE 1,4-BENZENEDIAMINE DIHYDROCHLORIDE [1,4']BIPIPERIDINYL DIHYDROCHLORIDE 1-(8-CHLORO-5-ISOQUINOLINESULFONYL)PIPERAZINE, DIHYDROCHLORIDE (S)-Isoquinoline-5-sulfonic acid pyrrolidin-3-ylamide dihydrochloride HA-1004 DIHYDROCHLORIDE

  • 5-IsoquinolinesulfonaMide,N-[2-(MethylaMino)ethyl]-, hydrochloride (1:2)
  • H-8 DIHYDROCHLORIDE
  • H-8 HYDROCHLORIDE
  • H-8
  • N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE 2HCL
  • N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE, DI-HCL SALT
  • N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE DIHYDROCHLORIDE
  • N-(2-[METHYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE
  • N-(2-(METHYLAMINO)ETHYL)ISOQUINOLINE-5-SULFONAMIDE DIHYDROCHLORIDE
  • H-8 DIHYDROCHLORIDE POTENT INHIBITOR OF C
  • H-8 dihydrochloride,98%
  • N-[2-(methylamino)ethyl]isoquinoline-5-sulfonamide
  • H8, dihydrochloride salt
  • 2-(5-isoquinolinylsulfonylamino)ethyl-methylammonium
  • H-8 dihydrochloride >98% (HPLC)
  • H8 (hydrochloride),H 8 (hydrochloride)
  • 113276-94-1
  • C12H15N3O2S2HCl