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LARIXYL ACETATE

Product Name
LARIXYL ACETATE
CAS No.
4608-49-5
Chemical Name
LARIXYL ACETATE
Synonyms
6-Acetyllarixol;LARIXYL ACETATE;Larixyl acetate-RM;Larixyl acetate, 10 mM in DMSO;Larixyl acetate (Larix-6-yl monoacetate);(13S)-6α-Acetoxylabda-8(17),14-diene-13-ol;[13S,(+)]-Labda-8(17),14-diene-6α,13-diol 6-acetate;(αS,1S,4S,4aS,8aR)-4-(Acetyloxy)-α-ethenyldecahydro-α,5,5,8a-tetramethyl-2-methylene-1-naphthalenepropanol;1-Naphthalenepropanol, 4-(acetyloxy)-α-ethenyldecahydro-α,5,5,8a-tetramethyl-2-methylene-, (αS,1S,4S,4aS,8aR)-;(1S,8aβ)-4α-[(S)-3-Methyl-3-hydroxy-4-pentenyl]decahydro-4aα,8,8-trimethyl-3-methylenenaphthalen-1β-ol 1-acetate
CBNumber
CB3344008
Molecular Formula
C22H36O3
Formula Weight
348.52
MOL File
4608-49-5.mol
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LARIXYL ACETATE Property

Melting point:
82℃
Boiling point:
419.3±28.0 °C(Predicted)
Density 
1.00±0.1 g/cm3 (20 ºC 760 Torr)
refractive index 
1.4826 (589.3 nm, 20℃)
storage temp. 
-20°C
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly)
form 
Solid
pka
14.47±0.29(Predicted)
color 
White to Off-White
Stability:
Hygroscopic
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHL89240
Product name
Larixyl acetate
Purity
phyproof? Reference Substance
Packaging
10mg
Price
$477
Updated
2025/07/31
Sigma-Aldrich
Product number
02730595
Product name
Larixyl acetate
Purity
primary pharmaceutical reference standard
Packaging
50mg
Price
$378
Updated
2023/06/20
TRC
Product number
L175955
Product name
Larixyl acetate
Packaging
50mg
Price
$145
Updated
2021/12/16
Biosynth Carbosynth
Product number
FL65055
Product name
Larixol acetate
Packaging
50mg
Price
$180
Updated
2021/12/16
Biosynth Carbosynth
Product number
FL65055
Product name
Larixol acetate
Packaging
100mg
Price
$340
Updated
2021/12/16
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LARIXYL ACETATE Chemical Properties,Usage,Production

Uses

Larixyl Acetate has pharmacological activity determined though in vitro anti-inflammatory activity of larch (Larix decidua L.) sawdust (Erratum).

in vivo

Larixyl acetate (5 mg/kg, i.p., once dailly for 7 days) significantly improves aortic endothelial dysfunction in TBI mice by inhibiting TRPC6 activity, particularly enhancing acetylcholine-induced dilation[3]. Larixyl acetate (5 mg/kg, i.p., once daily for 4 weeks) improves cardiac function in pressure overload-induced heart failure model by inhibiting TRPC6, reducing cardiac hypertrophy, fibrosis, and apoptosis[4].

Animal Model:Closed-head mild traumatic brain injury (mTBI) model, C57BL/6, 129S, 129S-C57BL/6-F2 mice, TRPC6 knockout mice[3]
Dosage:5 mg/kg
Administration:Intraperitoneal injection (i.p.), once daily for 7 days
Result:Significantly improved aortic endothelial function 7 days after TBI. Caused that acetylcholine (10 μM) induced dilation was significantly enhanced in Larixyl acetate-treated mice (In C57BL/6 mice, the Larixyl acetate group showed 96.9 %; in 129S-C57BL/6-F2 mice, the Larixyl acetate group showed 89.2 %).
Animal Model:Transverse aortic constriction (Tac) model for pressure overload-induced heart failure in mice[5]
Dosage:5 mg/kg
Administration:Intraperitoneal injection (i.p.), once daily for 4 weeks
Result:Significantly reduced cardiac hypertrophy, left ventricular pressure, and improved cardiac function (FS and EF increased). Improved TAC-induced cardiac fibrosis, cardiomyocyte apoptosis, and inhibited ER stress-related proteins (e.g., GRP78) expression.

IC 50

hTRPC6: 0.58 μM (IC50); hTRPC3: 6.83 μM (IC50)

LARIXYL ACETATE Preparation Products And Raw materials

Raw materials

Preparation Products

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LARIXYL ACETATE Suppliers

China 42 Germany 1 United Kingdom 1 United States 9 Global 53
Chengdu Biopurify Phytochemicals Ltd.
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+86-028-82633397 18982077548
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+86-28-82633165
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cwb1@biopurify.cn
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China
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Sichuan Wei Keqi Biological Technology Co., Ltd.
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028-81700200 18116577057
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028-81705658
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3003855609@qq.com
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China
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Wuxi Zhongkun Biochemical Technology Co., Ltd.
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0510-85629785 18013409632
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051085625359
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sales@reading-chemicals.com
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China
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Wuhan ChemFaces Biochemical Co., Ltd.
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18607101326 15172504745
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+86-27-84254680
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aileen@chemfaces.com
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China
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EMMX Biotechnology LLC
Tel
888-539-0666
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888-539-0666
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info@emmx.com
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United States
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Shanghai Haozhixiang Biotechnology Co., Ltd
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526763801 13301653310
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+86-21-51619052
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526763801@qq.com
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China
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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021-65675885
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info@efebio.com
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China
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Shanghai YuanYe Biotechnology Co., Ltd.
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021-61312847; 18021002903
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QQ:3008007432
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3008007409@qq.com
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China
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71826
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Nanjing Digger Medical Technology Co. Ltd.
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025-025-51191215 18013836722
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025-51191215
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2399235533@qq.com
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China
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Shenzhen Polymeri Biochemical Technology Co., Ltd.
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+86-400-002-6226 +86-13028896684;
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sales@rrkchem.com
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China
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4608-49-5, LARIXYL ACETATERelated Search:

alpha-Terpineol alpha-Cyperone beta-Sitosterol MOSLOFLAVONE Hydroxyecdysone 2-(3,4-Dihydroxyphenyl)-8-(2-O-beta-L-galactopyranosyl-beta-D-glucopyranosyl)-5,7-dihydroxy-4H-1-Benzopyran-4-one Artemether beta-Eudesmol hydroxygenkwanin (4E,6E)-1,7-Diphenyl-4,6-heptadien-3-one LARIXYL ACETATE DIHYDROMYRCENYL ACETATE LARIXOL ACETATE

  • LARIXYL ACETATE
  • (13S)-6α-Acetoxylabda-8(17),14-diene-13-ol
  • (1S,8aβ)-4α-[(S)-3-Methyl-3-hydroxy-4-pentenyl]decahydro-4aα,8,8-trimethyl-3-methylenenaphthalen-1β-ol 1-acetate
  • (1S,8aβ)-4α-[(S)-3-Methyl-3-hydroxy-4-pentenyl]decahydro-4aα,8,8-trimethyl-3-methylenenaphthalene-1β-ol 1-acetate
  • [13S,(+)]-Labda-8(17),14-diene-6α,13-diol 6-acetate
  • 6-Acetyllarixol
  • (αS,1S,4S,4aS,8aR)-4-(Acetyloxy)-α-ethenyldecahydro-α,5,5,8a-tetramethyl-2-methylene-1-naphthalenepropanol
  • Larixyl acetate (Larix-6-yl monoacetate)
  • 1-Naphthalenepropanol, 4-(acetyloxy)-α-ethenyldecahydro-α,5,5,8a-tetramethyl-2-methylene-, (αS,1S,4S,4aS,8aR)-
  • Larixyl acetate,TRP Channel,inhibit,Transient receptor potential channels,Inhibitor,systemic endothelial dysfunction,Human papillomavirus,HPV,HEK 293,Larixyl
  • Larixyl acetate-RM
  • Larixyl acetate, 10 mM in DMSO
  • 4608-49-5