ChemicalBook > CAS DataBase List > LARIXYL ACETATE

LARIXYL ACETATE

Product Name: LARIXYL ACETATE
CAS No.: 4608-49-5
Chemical Name: LARIXYL ACETATE
Synonyms: 6-Acetyllarixol;LARIXYL ACETATE;Larixyl acetate-RM;Larixyl acetate, 10 mM in DMSO;Larixyl acetate (Larix-6-yl monoacetate);(13S)-6α-Acetoxylabda-8(17),14-diene-13-ol;[13S,(+)]-Labda-8(17),14-diene-6α,13-diol 6-acetate;(αS,1S,4S,4aS,8aR)-4-(Acetyloxy)-α-ethenyldecahydro-α,5,5,8a-tetramethyl-2-methylene-1-naphthalenepropanol;1-Naphthalenepropanol, 4-(acetyloxy)-α-ethenyldecahydro-α,5,5,8a-tetramethyl-2-methylene-, (αS,1S,4S,4aS,8aR)-;(1S,8aβ)-4α-[(S)-3-Methyl-3-hydroxy-4-pentenyl]decahydro-4aα,8,8-trimethyl-3-methylenenaphthalen-1β-ol 1-acetate
CBNumber: CB3344008
Molecular Formula: C22H36O3
Formula Weight: 348.52
MOL File: 4608-49-5.mol

Less

LARIXYL ACETATE Property

Melting point:: 82℃
Boiling point:: 419.3±28.0 °C(Predicted)
Density: 1.00±0.1 g/cm3 (20 ºC 760 Torr)
refractive index: 1.4826 (589.3 nm, 20℃)
storage temp.: -20°C
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
form: Solid
pka: 14.47±0.29(Predicted)
color: White to Off-White
Stability:: Hygroscopic

Less

Safety

WGK Germany: 3

Less

Hazard and Precautionary Statements (GHS)

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHL89240
Product name: Larixyl acetate
Purity: phyproof? Reference Substance
Packaging: 10mg
Price: $477
Updated: 2025/07/31

Sigma-Aldrich

Product number: 02730595
Product name: Larixyl acetate
Purity: primary pharmaceutical reference standard
Packaging: 50mg
Price: $378
Updated: 2023/06/20

TRC

Product number: L175955
Product name: Larixyl acetate
Packaging: 50mg
Price: $145
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FL65055
Product name: Larixol acetate
Packaging: 50mg
Price: $180
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FL65055
Product name: Larixol acetate
Packaging: 100mg
Price: $340
Updated: 2021/12/16

Less

LARIXYL ACETATE Chemical Properties,Usage,Production

Uses

Larixyl Acetate has pharmacological activity determined though in vitro anti-inflammatory activity of larch (Larix decidua L.) sawdust (Erratum).

in vivo

Larixyl acetate (5 mg/kg, i.p., once dailly for 7 days) significantly improves aortic endothelial dysfunction in TBI mice by inhibiting TRPC6 activity, particularly enhancing acetylcholine-induced dilation^[3]. Larixyl acetate (5 mg/kg, i.p., once daily for 4 weeks) improves cardiac function in pressure overload-induced heart failure model by inhibiting TRPC6, reducing cardiac hypertrophy, fibrosis, and apoptosis^[4].

Animal Model:	Closed-head mild traumatic brain injury (mTBI) model, C57BL/6, 129S, 129S-C57BL/6-F2 mice, TRPC6 knockout mice^[3]
Dosage:	5 mg/kg
Administration:	Intraperitoneal injection (i.p.), once daily for 7 days
Result:	Significantly improved aortic endothelial function 7 days after TBI. Caused that acetylcholine (10 μM) induced dilation was significantly enhanced in Larixyl acetate-treated mice (In C57BL/6 mice, the Larixyl acetate group showed 96.9 %; in 129S-C57BL/6-F2 mice, the Larixyl acetate group showed 89.2 %).

Animal Model:	Transverse aortic constriction (Tac) model for pressure overload-induced heart failure in mice^[5]
Dosage:	5 mg/kg
Administration:	Intraperitoneal injection (i.p.), once daily for 4 weeks
Result:	Significantly reduced cardiac hypertrophy, left ventricular pressure, and improved cardiac function (FS and EF increased). Improved TAC-induced cardiac fibrosis, cardiomyocyte apoptosis, and inhibited ER stress-related proteins (e.g., GRP78) expression.

IC 50

hTRPC6: 0.58 μM (IC₅₀); hTRPC3: 6.83 μM (IC₅₀)

LARIXYL ACETATE Preparation Products And Raw materials

Raw materials

Preparation Products

Less

LARIXYL ACETATE Suppliers

China 42 Germany 1 United Kingdom 1 United States 9 Global 53

Chengdu Biopurify Phytochemicals Ltd.

Tel: +86-028-82633397 18982077548
Fax: +86-28-82633165
Email: cwb1@biopurify.cn
Country: China
ProdList: 2376
Advantage: 60

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7778
Advantage: 56

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15178
Advantage: 58

Wuhan ChemFaces Biochemical Co., Ltd.

Tel: 18607101326 15172504745
Fax: +86-27-84254680
Email: aileen@chemfaces.com
Country: China
ProdList: 6905
Advantage: 55

Shanghai Haozhixiang Biotechnology Co., Ltd

Tel: 526763801 13301653310
Fax: +86-21-51619052
Email: 526763801@qq.com
Country: China
ProdList: 9287
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Nanjing Digger Medical Technology Co. Ltd.

Tel: 025-025-51191215 18013836722
Fax: 025-51191215
Email: 2399235533@qq.com
Country: China
ProdList: 4933
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57422
Advantage: 58

Aktin Chemicals, Inc.

Tel: 028-85159085
Fax: 86-28-85159085 Ex:604
Email: info@aktinchem.com
Country: CHINA
ProdList: 1025
Advantage: 58

Chengdu Jiuding Chemical Technology Co., Ltd. - Song Bo

Tel: 18584079237
Email: 312074905@qq.com
Country: China
ProdList: 2513
Advantage: 58

Wuxi Helen Biotechnology Co., Ltd.,

Tel: 0510-85629785 18013409632
Fax: 0510-85625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 14081
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-025-85560043 17301488900
Fax: 025-85563444
Email: info@synzest.com
Country: China
ProdList: 9286
Advantage: 58

Aktin Chemicals, Inc.

Tel: 028-85159085
Email: info@aktinchem.com
Country: China
ProdList: 1860
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

Foshan Treasure Biotechnology Co., Ltd

Tel: 0757-85921206 18520245316
Email: 2329783215@qq.com
Country: China
ProdList: 12661
Advantage: 58

Shanghai Universal Biotech Co.,Ltd

Tel: 15921930842 15921930842
Email: yh-wang@univ-bio.com
Country: China
ProdList: 25004
Advantage: 58

Jiangsu Yongjian Pharmaceutical Technology Co., Ltd

Tel: 17701422015
Email: 3582572959@qq.com
Country: China
ProdList: 980
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 18351873721
Email: helen.zhang@synzest.com
Country: China
ProdList: 8295
Advantage: 58

Shanghai Moqi Biological Technology Co., LTD

Tel: 021-38218169 13681877033
Email: 2702713455@qq.com
Country: China
ProdList: 9997
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Naturewill Biotechnology Co., Ltd.

Tel: 028-82632533 18113192475
Email: 3157321941@qq.com
Country: China
ProdList: 4993
Advantage: 58

Shanghai Aladdin Biochemical Technology Co.,Ltd.

Tel: 400-6206333 13167063860
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 48457
Advantage: 58

RD International Technology Co., Limited

Tel: 18024082417
Email: market@ubiochem.com
Country: China
ProdList: 9835
Advantage: 58

SHANGHAI ZZBIO CO., LTD.

Tel: 15102117276 19921389125
Email: tech@zzbioco.com
Country: China
ProdList: 12064
Advantage: 58

Mensura Group Limited

Tel: 17318633522
Fax: 028-87362290
Email: 18109034517@163.com
Country: China
ProdList: 2898
Advantage: 58

Tanmo Quality Inspection Technology Co., Ltd.

Tel: 4008-099-669
Email: 23419001name@qq.com
Country: CHINA
ProdList: 6043
Advantage: 58

BePure (Beijing) Biotechnology Co.

Tel: 58896805
Email: 7993601name@qq.com
Country: CHINA
ProdList: 6620
Advantage: 58

Hubei Danding Pharmaceutical Technology Co., Ltd

Tel: 17701422019
Email: 1559451077@qq.com
Country: China
ProdList: 8165
Advantage: 58

Sangon Biotech (Shanghai) Co.,Ltd.

Tel: 400-821-026
Email: Sales@sangon.com
Country: China
ProdList: 6710
Advantage: 58

Chengdu DeSiTe Biological Technology Co., Ltd

Tel: 17308096051
Email: 3001048290@qq.com
Country: China
ProdList: 6219
Advantage: 58

Cayman Chemical Company

Tel: 800-364-9897
Email: sales@caymanchem.com
Country: China
ProdList: 6838
Advantage: 58

Merck KGaA

Tel: 21-20338288
Email: ordercn@merckgroup.com
Country: China
ProdList: 6394
Advantage: 58

Biosynth Biological Technology (Suzhou) Co Ltd

Tel: 51288865780
Email: sales@biosynth.com
Country: China
ProdList: 6051
Advantage: 58

Santa Cruz Biotechnology Inc

Tel: 021-60936350
Email: scbt@scbt.com
Country: China
ProdList: 6594
Advantage: 58

Chengdu Biopurify Ltd.

Tel: 28-82633860 18982077548
Email: cwb1@biopurify.cn
Country: China
ProdList: 3842
Advantage: 58

Chengdu Biopurify Phytochemicals Ltd.

Tel: +86-28-82633860; +8618080483897
Email: sales@biopurify.com
Country: China
ProdList: 3751
Advantage: 58

DAYANG CHEM (HANGZHOU) CO.,LTD

Tel: +86-88938639 +86-17705817739
Email: info@dycnchem.com
Country: China
ProdList: 53899
Advantage: 58

Mensura Group Limited

Tel: 18780014153
Fax: 028-87362290
Email: 1058503172@qq.com
Country: China
ProdList: 2900
Advantage: 58

Neobioscience Co., Ltd.

Tel: --
Fax: --
Email: info@neobioscience.com
Country: CHINA
ProdList: 6207
Advantage: 58

Proteintech China

Tel: --
Fax: --
Email: Proteintech-CN@ptglab.com
Country: CHINA
ProdList: 6290
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

4608-49-5, LARIXYL ACETATERelated Search:

alpha-Terpineol alpha-Cyperone beta-Sitosterol MOSLOFLAVONE Hydroxyecdysone 2-(3,4-Dihydroxyphenyl)-8-(2-O-beta-L-galactopyranosyl-beta-D-glucopyranosyl)-5,7-dihydroxy-4H-1-Benzopyran-4-one Artemether beta-Eudesmol hydroxygenkwanin (4E,6E)-1,7-Diphenyl-4,6-heptadien-3-one LARIXYL ACETATE DIHYDROMYRCENYL ACETATE LARIXOL ACETATE

LARIXYL ACETATE

(13S)-6α-Acetoxylabda-8(17),14-diene-13-ol

(1S,8aβ)-4α-[(S)-3-Methyl-3-hydroxy-4-pentenyl]decahydro-4aα,8,8-trimethyl-3-methylenenaphthalen-1β-ol 1-acetate

(1S,8aβ)-4α-[(S)-3-Methyl-3-hydroxy-4-pentenyl]decahydro-4aα,8,8-trimethyl-3-methylenenaphthalene-1β-ol 1-acetate

[13S,(+)]-Labda-8(17),14-diene-6α,13-diol 6-acetate

6-Acetyllarixol

(αS,1S,4S,4aS,8aR)-4-(Acetyloxy)-α-ethenyldecahydro-α,5,5,8a-tetramethyl-2-methylene-1-naphthalenepropanol

Larixyl acetate (Larix-6-yl monoacetate)

1-Naphthalenepropanol, 4-(acetyloxy)-α-ethenyldecahydro-α,5,5,8a-tetramethyl-2-methylene-, (αS,1S,4S,4aS,8aR)-

Larixyl acetate,TRP Channel,inhibit,Transient receptor potential channels,Inhibitor,systemic endothelial dysfunction,Human papillomavirus,HPV,HEK 293,Larixyl

Larixyl acetate-RM

Larixyl acetate, 10 mM in DMSO

4608-49-5