1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINE

Product Name: 1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINE
CAS No.: 103816-19-9
Chemical Name: 1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINE
Synonyms: Irinotecan Impurity 23;1-CHLOROCARBONYL-4-PIPERIDINOPERIDINE;1,4']Bipiperidinyl-1'-carbonyl chloride; 4-piperidylpiperidinecarbonyl chloride;1,4'-bipiperidine]-1'-carbonyl chloride;4-PIPERIDINOPIPERIDINE-1-CARBONYL CHLOR&;4-Piperidinopiperidine-1-carbonyl chloride;4-piperidin-1-ylpiperidine-1-carbonyl chloride;1,4'-Bipiperidine]-1'-carbonyl chloride (9CI, ACI);forMyl[4-(piperidin-1-yl)piperidin-1-yl]chloranuide
CBNumber: CB3346794
Molecular Formula: C11H19ClN2O
Formula Weight: 230.73
MOL File: 103816-19-9.mol

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1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINE Property

Melting point:: 60-64°C
Boiling point:: 344.5±31.0 °C(Predicted)
Density: 1.184±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Acetonitrile (Slightly), Chloroform (Slightly, Heated)
pka: 9.19±0.20(Predicted)
form: Solid
color: Off-White to Light Beige
Stability:: Moisture Sensitive
InChI: 1S/C11H19ClN2O/c12-11(15)14-8-4-10(5-9-14)13-6-2-1-3-7-13/h10H,1-9H2
InChIKey: YDNSNQRKIINKPV-UHFFFAOYSA-N
SMILES: ClC(=O)N1CCC(CC1)N2CCCCC2

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Safety

Hazard Codes: C
Risk Statements: 34
Safety Statements: 26-27-36/37/39-45
RIDADR: UN 3261 8 / PGIII
WGK Germany: 3
Storage Class: 8A - Combustible corrosive hazardous materials
Hazard Classifications: Acute Tox. 4 Oral
Skin Corr. 1B

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC

Product number: P482100
Product name: 4-Piperidinopiperidine-1-carbonyl chloride
Packaging: 5g
Price: $185
Updated: 2021/12/16

TRC

Product number: P482100
Product name: 4-Piperidinopiperidine-1-carbonyl chloride
Packaging: 25g
Price: $580
Updated: 2021/12/16

TRC

Product number: P482100
Product name: 4-Piperidinopiperidine-1-carbonyl chloride
Packaging: 100g
Price: $1550
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0093636
Product name: [1,4']BIPIPERIDINYL-1'-CARBONYL CHLORIDE
Purity: 95.00%
Packaging: 1G
Price: $688.23
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 48348
Product name: 4-Piperidinopiperidine-1-carbonyl chloride
Packaging: 25g
Price: $800
Updated: 2021/12/16

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1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINE Chemical Properties,Usage,Production

Uses

Reactant for synthesis of:

Macrocyclic ureas as selective Chk1 inhibitors
Etoposide prodrug for dual prodrug-enzyme antitumor therapy
Phosphodiesterase 4 inhibitors
Camptothecin analogs

Synthesis

4897-50-1

32315-10-9

103816-19-9

The general procedure for the synthesis of piperidinyl piperidine carbonyl chloride from 4-piperidinyl piperidine and triphosgene is as follows: Example 1 Synthesis of [1,4']bipiperidine-1'-carbonyl chloride (II): triphosgene (16.48 g) was dissolved in methylene chloride (200 ml), and methylene chloride solution of 4-piperidinyl piperidine (20 g) (200 ml) was slowly added, and the temperature of the reaction was maintained at 20 to 25 °C and the reaction time was 1-2 hours. During this process, dichloromethane was removed by distillation and acetonitrile was added subsequently. Distillation was continued to remove dichloromethane and acetonitrile until the reaction temperature was raised to 70°C. Fresh dichloromethane was added to the reaction mixture and after forming a homogeneous slurry, potassium carbonate (30-35 g) was added and the reaction mixture was stirred for 1-2 hours. After completion of the reaction, the reaction mixture was filtered and the filtrate was concentrated. Hexane was slowly added to the concentrate under stirring to precipitate a solid product. The solid was collected by filtration, washed with hexane and dried under reduced pressure at about 40 °C to give 27 g of product (98.5% yield). The product was analyzed by GC showing a purity of 99.80% and no dimer impurities were detected.

References

[1] Patent: US2011/144342, 2011, A1. Location in patent: Page/Page column 7
[2] Patent: EP2341046, 2011, A2. Location in patent: Page/Page column 9
[3] Patent: US2007/208050, 2007, A1. Location in patent: Page/Page column 7
[4] Patent: WO2009/97695, 2009, A1. Location in patent: Page/Page column 114-115
[5] Patent: WO2006/16203, 2006, A1. Location in patent: Page/Page column 8-9

1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINE Suppliers

China 58 Germany 1 India 4 Switzerland 1 United Kingdom 3 United States 6 Global 73

Shijiazhuang Sdyano Fine Chemical Co., Ltd.

Tel: 0311-89250318 031166536426
Fax: 4000311741
Email: master@sjzsdyn.com
Country: China
ProdList: 2760
Advantage: 65

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070 13913916777;
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 15778
Advantage: 64

Maya High Purity Chemicals

Tel: +86 (573) 82222445 (0)18006601000 452520369
Fax: +86 (573) 82222643
Email: sales@maya-r.com
Country: China
ProdList: 11707
Advantage: 57

S.Z. PhyStandard Bio-Tech. Co., Ltd.

Tel: 0755-4000505016 13380397412
Fax: 0755 28094224
Email: 3001272453@qq.com
Country: China
ProdList: 5157
Advantage: 50

Shanghai Balmxy Pharmaceutical Co., Ltd

Tel: 021-24206007 13764915196
Fax: 86-021-23027023
Email: sales@balmxy.com
Country: China
ProdList: 6887
Advantage: 55

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66028182 18626450290
Email: yftan@aikonchem.com
Country: China
ProdList: 16676
Advantage: 50

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51395
Advantage: 80

Shijiazhuang Sdyano Fine Chemical Co., Ltd.

Tel: 0311-89250318 031166536426
Fax: 4000311741
Email: master@sjzsdyn.com
Country: China
ProdList: 3495
Advantage: 58

Shanghai QianYan Bio-technology Co., Ltd

Tel: 02781293128
Email: orders@biochemsafebuy.com
Country: China
ProdList: 9923
Advantage: 55

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

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View Lastest Price from 1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINE 103816-19-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Hebei Miaobian Biotechnology Co., Ltd

Product: 1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINE 103816-19-9
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99.99
Supply Ability: 10Ton
Release date: 2021-04-28

Career Henan Chemical Co

Product: 1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINE 103816-19-9
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 100KG
Release date: 2018-12-21

103816-19-9, 1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINERelated Search:

1-benzyl-4-(piperidin-1-yl)-1,2,3,6-tetrahydropyridine 12-ethyl-8-methyl-9-oxo-7-propionyl-9,11-dihydroindolizino[1,2-b]quinolin-2-yl [1,4'-bipiperidine]-1'-carboxylate [1,4'-Bipiperidine]-1'-carboxylic acid Irinotecan Hydroxyl Acid Irinotecan Lactone IMpurity Irinotecan Impurity 26 Irinotecan Impurity 18 Irinotecan IMpurity G 11-Desethyl Irinotecan Irinotecan Impurity 3 Irinotecan Impurity 8 Irinotecan Impurity 29 1-Chlorocarbonyl-4-piperidinopiperidine hydrochloride Dimethylcarbamoyl chloride Diethylcarbamyl chloride N-CHLOROMETHYL PIPERIDINE 1-PIPERIDINECARBONYL CHLORIDE 1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINE

1-CHLOROCARBONYL-4-PIPERIDINOPERIDINE

forMyl[4-(piperidin-1-yl)piperidin-1-yl]chloranuide

4-<WBR>Piperidinopiperidine-<WBR>1-<WBR>carbonyl chloride

4-Piperidinopiperidine-1-carbonyl chloride

Irinotecan Impurity 23

4-PIPERIDINOPIPERIDINE-1-CARBONYL CHLOR&

1,4'-Bipiperidine]-1'-carbonyl chloride (9CI, ACI)

4-piperidylpiperidinecarbonyl chloride

1,4']Bipiperidinyl-1'-carbonyl chloride

4-piperidin-1-ylpiperidine-1-carbonyl chloride

1,4'-bipiperidine]-1'-carbonyl chloride

103816-19-9

C11H19ClN2O