1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINE
- Product Name
- 1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINE
- CAS No.
- 103816-19-9
- Chemical Name
- 1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINE
- Synonyms
- Irinotecan Impurity 23;1-CHLOROCARBONYL-4-PIPERIDINOPERIDINE;1,4']Bipiperidinyl-1'-carbonyl chloride; 4-piperidylpiperidinecarbonyl chloride;1,4'-bipiperidine]-1'-carbonyl chloride;4-PIPERIDINOPIPERIDINE-1-CARBONYL CHLOR&;4-Piperidinopiperidine-1-carbonyl chloride;4-piperidin-1-ylpiperidine-1-carbonyl chloride;1,4'-Bipiperidine]-1'-carbonyl chloride (9CI, ACI);forMyl[4-(piperidin-1-yl)piperidin-1-yl]chloranuide
- CBNumber
- CB3346794
- Molecular Formula
- C11H19ClN2O
- Formula Weight
- 230.73
- MOL File
- 103816-19-9.mol
1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINE Property
- Melting point:
- 60-64°C
- Boiling point:
- 344.5±31.0 °C(Predicted)
- Density
- 1.184±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Acetonitrile (Slightly), Chloroform (Slightly, Heated)
- form
- Solid
- pka
- 9.19±0.20(Predicted)
- color
- Off-White to Light Beige
- Stability:
- Moisture Sensitive
Safety
- Hazard Codes
- C
- Risk Statements
- 34
- Safety Statements
- 26-27-36/37/39-45
- RIDADR
- UN 3261 8 / PGIII
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- P482100
- Product name
- 4-Piperidinopiperidine-1-carbonyl chloride
- Packaging
- 5g
- Price
- $185
- Updated
- 2021/12/16
- Product number
- P482100
- Product name
- 4-Piperidinopiperidine-1-carbonyl chloride
- Packaging
- 25g
- Price
- $580
- Updated
- 2021/12/16
- Product number
- P482100
- Product name
- 4-Piperidinopiperidine-1-carbonyl chloride
- Packaging
- 100g
- Price
- $1550
- Updated
- 2021/12/16
- Product number
- CHM0093636
- Product name
- [1,4']BIPIPERIDINYL-1'-CARBONYL CHLORIDE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $688.23
- Updated
- 2021/12/16
- Product number
- 48348
- Product name
- 4-Piperidinopiperidine-1-carbonyl chloride
- Packaging
- 25g
- Price
- $800
- Updated
- 2021/12/16
1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINE Chemical Properties,Usage,Production
Uses
Reactant for synthesis of:
- Macrocyclic ureas as selective Chk1 inhibitors
- Etoposide prodrug for dual prodrug-enzyme antitumor therapy
- Phosphodiesterase 4 inhibitors
- Camptothecin analogs
Synthesis
4897-50-1
32315-10-9
103816-19-9
The general procedure for the synthesis of piperidinyl piperidine carbonyl chloride from 4-piperidinyl piperidine and triphosgene is as follows: Example 1 Synthesis of [1,4']bipiperidine-1'-carbonyl chloride (II): triphosgene (16.48 g) was dissolved in methylene chloride (200 ml), and methylene chloride solution of 4-piperidinyl piperidine (20 g) (200 ml) was slowly added, and the temperature of the reaction was maintained at 20 to 25 °C and the reaction time was 1-2 hours. During this process, dichloromethane was removed by distillation and acetonitrile was added subsequently. Distillation was continued to remove dichloromethane and acetonitrile until the reaction temperature was raised to 70°C. Fresh dichloromethane was added to the reaction mixture and after forming a homogeneous slurry, potassium carbonate (30-35 g) was added and the reaction mixture was stirred for 1-2 hours. After completion of the reaction, the reaction mixture was filtered and the filtrate was concentrated. Hexane was slowly added to the concentrate under stirring to precipitate a solid product. The solid was collected by filtration, washed with hexane and dried under reduced pressure at about 40 °C to give 27 g of product (98.5% yield). The product was analyzed by GC showing a purity of 99.80% and no dimer impurities were detected.
References
[1] Patent: US2011/144342, 2011, A1. Location in patent: Page/Page column 7
[2] Patent: EP2341046, 2011, A2. Location in patent: Page/Page column 9
[3] Patent: US2007/208050, 2007, A1. Location in patent: Page/Page column 7
[4] Patent: WO2009/97695, 2009, A1. Location in patent: Page/Page column 114-115
[5] Patent: WO2006/16203, 2006, A1. Location in patent: Page/Page column 8-9
1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINE Suppliers
- Tel
- --
- Fax
- --
- info@paragos.com
- Country
- Germany
- ProdList
- 6371
- Advantage
- 39
View Lastest Price from 1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINE manufacturers
- Product
- 1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINE 103816-19-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- 1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINE 103816-19-9
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99.99
- Supply Ability
- 10Ton
- Release date
- 2021-04-28
- Product
- 1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINE 103816-19-9
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-12-21