ChemicalBook > CAS DataBase List > 1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINE

1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINE

Product Name
1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINE
CAS No.
103816-19-9
Chemical Name
1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINE
Synonyms
Irinotecan Impurity 23;1-CHLOROCARBONYL-4-PIPERIDINOPERIDINE;1,4']Bipiperidinyl-1'-carbonyl chloride; 4-piperidylpiperidinecarbonyl chloride;1,4'-bipiperidine]-1'-carbonyl chloride;4-PIPERIDINOPIPERIDINE-1-CARBONYL CHLOR&;4-Piperidinopiperidine-1-carbonyl chloride;4-piperidin-1-ylpiperidine-1-carbonyl chloride;1,4'-Bipiperidine]-1'-carbonyl chloride (9CI, ACI);forMyl[4-(piperidin-1-yl)piperidin-1-yl]chloranuide
CBNumber
CB3346794
Molecular Formula
C11H19ClN2O
Formula Weight
230.73
MOL File
103816-19-9.mol
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1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINE Property

Melting point:
60-64°C
Boiling point:
344.5±31.0 °C(Predicted)
Density 
1.184±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Acetonitrile (Slightly), Chloroform (Slightly, Heated)
form 
Solid
pka
9.19±0.20(Predicted)
color 
Off-White to Light Beige
Stability:
Moisture Sensitive
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Safety

Hazard Codes 
C
Risk Statements 
34
Safety Statements 
26-27-36/37/39-45
RIDADR 
UN 3261 8 / PGIII
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC
Product number
P482100
Product name
4-Piperidinopiperidine-1-carbonyl chloride
Packaging
5g
Price
$185
Updated
2021/12/16
TRC
Product number
P482100
Product name
4-Piperidinopiperidine-1-carbonyl chloride
Packaging
25g
Price
$580
Updated
2021/12/16
TRC
Product number
P482100
Product name
4-Piperidinopiperidine-1-carbonyl chloride
Packaging
100g
Price
$1550
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0093636
Product name
[1,4']BIPIPERIDINYL-1'-CARBONYL CHLORIDE
Purity
95.00%
Packaging
1G
Price
$688.23
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
48348
Product name
4-Piperidinopiperidine-1-carbonyl chloride
Packaging
25g
Price
$800
Updated
2021/12/16
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1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINE Chemical Properties,Usage,Production

Uses

Reactant for synthesis of:

  • Macrocyclic ureas as selective Chk1 inhibitors
  • Etoposide prodrug for dual prodrug-enzyme antitumor therapy
  • Phosphodiesterase 4 inhibitors
  • Camptothecin analogs

Synthesis

4897-50-1

32315-10-9

103816-19-9

The general procedure for the synthesis of piperidinyl piperidine carbonyl chloride from 4-piperidinyl piperidine and triphosgene is as follows: Example 1 Synthesis of [1,4']bipiperidine-1'-carbonyl chloride (II): triphosgene (16.48 g) was dissolved in methylene chloride (200 ml), and methylene chloride solution of 4-piperidinyl piperidine (20 g) (200 ml) was slowly added, and the temperature of the reaction was maintained at 20 to 25 °C and the reaction time was 1-2 hours. During this process, dichloromethane was removed by distillation and acetonitrile was added subsequently. Distillation was continued to remove dichloromethane and acetonitrile until the reaction temperature was raised to 70°C. Fresh dichloromethane was added to the reaction mixture and after forming a homogeneous slurry, potassium carbonate (30-35 g) was added and the reaction mixture was stirred for 1-2 hours. After completion of the reaction, the reaction mixture was filtered and the filtrate was concentrated. Hexane was slowly added to the concentrate under stirring to precipitate a solid product. The solid was collected by filtration, washed with hexane and dried under reduced pressure at about 40 °C to give 27 g of product (98.5% yield). The product was analyzed by GC showing a purity of 99.80% and no dimer impurities were detected.

References

[1] Patent: US2011/144342, 2011, A1. Location in patent: Page/Page column 7
[2] Patent: EP2341046, 2011, A2. Location in patent: Page/Page column 9
[3] Patent: US2007/208050, 2007, A1. Location in patent: Page/Page column 7
[4] Patent: WO2009/97695, 2009, A1. Location in patent: Page/Page column 114-115
[5] Patent: WO2006/16203, 2006, A1. Location in patent: Page/Page column 8-9

1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINE Suppliers

China 58 Germany 1 India 4 Switzerland 1 United Kingdom 3 United States 6 Global 73
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View Lastest Price from 1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINE 103816-19-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27
Hebei Miaobian Biotechnology Co., Ltd
Product
1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINE 103816-19-9
Price
US $10.00/KG
Min. Order
1KG
Purity
99.99
Supply Ability
10Ton
Release date
2021-04-28
Career Henan Chemical Co
Product
1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINE 103816-19-9
Price
US $1.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
100KG
Release date
2018-12-21

103816-19-9, 1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINERelated Search:

1-benzyl-4-(piperidin-1-yl)-1,2,3,6-tetrahydropyridine 12-ethyl-8-methyl-9-oxo-7-propionyl-9,11-dihydroindolizino[1,2-b]quinolin-2-yl [1,4'-bipiperidine]-1'-carboxylate [1,4'-Bipiperidine]-1'-carboxylic acid Irinotecan Hydroxyl Acid Irinotecan Lactone IMpurity Irinotecan Impurity 26 Irinotecan Impurity 18 Irinotecan IMpurity G 11-Desethyl Irinotecan Irinotecan Impurity 3 Irinotecan Impurity 8 Irinotecan Impurity 29 1-Chlorocarbonyl-4-piperidinopiperidine hydrochloride Dimethylcarbamoyl chloride Diethylcarbamyl chloride N-CHLOROMETHYL PIPERIDINE 1-PIPERIDINECARBONYL CHLORIDE 1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINE

  • 1-CHLOROCARBONYL-4-PIPERIDINOPERIDINE
  • forMyl[4-(piperidin-1-yl)piperidin-1-yl]chloranuide
  • 4-<WBR>Piperidinopiperidine-<WBR>1-<WBR>carbonyl chloride
  • 4-Piperidinopiperidine-1-carbonyl chloride
  • Irinotecan Impurity 23
  • 4-PIPERIDINOPIPERIDINE-1-CARBONYL CHLOR&
  • 1,4'-Bipiperidine]-1'-carbonyl chloride (9CI, ACI)
  • 4-piperidylpiperidinecarbonyl chloride
  • 1,4']Bipiperidinyl-1'-carbonyl chloride
  • 4-piperidin-1-ylpiperidine-1-carbonyl chloride
  • 1,4'-bipiperidine]-1'-carbonyl chloride
  • 103816-19-9
  • C11H19ClN2O