Methyl 4-oxotetrahydrothiophene-3-carboxylate
- Product Name
- Methyl 4-oxotetrahydrothiophene-3-carboxylate
- CAS No.
- 2689-68-1
- Chemical Name
- Methyl 4-oxotetrahydrothiophene-3-carboxylate
- Synonyms
- AKOS 92615;methyl tetrahydro-4-oxo-3-thenoate;4-CARBOMETHOXYTETRAHYDRO-3-THIOPHENE;4-CARBOMETHOXYTETRAHYDRO-3-THIOPHENONE;3-Carbomethoxytetrahydrothiophene-4-one;METHYL 3-OXOTETRAHYDROTHIOPHENE4-CARBOXYLATE;METHYL 4-OXOTETRAHYDROTHIOPHENE-3-CARBOXYLATE;Methyl 4-oxotetrahydrothiophene-3-carboxylate ,97%;Methyl 4-oxotetrahydrothiophene-3-carboxylate, 95+%;tetrahydro-4-oxo-3-thiophenecarboxylicacimethylester
- CBNumber
- CB3354748
- Molecular Formula
- C6H8O3S
- Formula Weight
- 160.19
- MOL File
- 2689-68-1.mol
Methyl 4-oxotetrahydrothiophene-3-carboxylate Property
- Melting point:
- 37-38 °C
- Boiling point:
- 95 °C
- Density
- 1.309±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- solubility
- Chloroform
- form
- Solid
- pka
- 10.52±0.20(Predicted)
- color
- Light Yellow
- InChI
- InChI=1S/C6H8O3S/c1-9-6(8)4-2-10-3-5(4)7/h4H,2-3H2,1H3
- InChIKey
- LEAKUJFYXNILRB-UHFFFAOYSA-N
- SMILES
- C1SCC(=O)C1C(OC)=O
- EPA Substance Registry System
- 3-Thiophenecarboxylic acid, tetrahydro-4-oxo-, methyl ester (2689-68-1)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- T294170
- Product name
- Tetrahydro-4-oxo-3-thiophenecarboxylicAcidMethylEster
- Packaging
- 5G
- Price
- $440
- Updated
- 2021/12/16
- Product number
- T294170
- Product name
- Tetrahydro-4-oxo-3-thiophenecarboxylicAcidMethylEster
- Packaging
- 25g
- Price
- $1650
- Updated
- 2021/12/16
- Product number
- CHM0030710
- Product name
- METHYL 4-OXOTETRAHYDROTHIOPHENE-3-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 10G
- Price
- $1320.38
- Updated
- 2021/12/16
- Product number
- CHM0030710
- Product name
- METHYL 4-OXOTETRAHYDROTHIOPHENE-3-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $631.34
- Updated
- 2021/12/16
- Product number
- 67223
- Product name
- Tetrahydro-4-oxo-3-thiophenecarboxylicAcidMethylEster
- Packaging
- 500mg
- Price
- $650
- Updated
- 2021/12/16
Methyl 4-oxotetrahydrothiophene-3-carboxylate Chemical Properties,Usage,Production
Chemical Properties
White solid
Uses
Methyl 4-oxotetrahydrothiophene-3-carboxylate is used in the preparation of a new class of neuroleptic agents.
Synthesis
2,3,4,5-Tetrahydro-4-oxo-3-thiophene carboxylic acid, methyl ester (L75a): 25.3 g (1.1 mol) of sodium were implemented in 190 mL abs. methanol to methylate. To methylate solution 70 g (0.360 mol) (L74) was added dropwise at the boiling point and the reaction mixture was heated for 45 min under reflux. The cooling mixture was poured onto a mixture of 500 mL ice and 300 mL water, acidified with 100 mL conc. HCl and the oily precipitating product was brought to crystallize under cooling with ice/sodium chloride bath. The crystals were sucked off, resumed in 100 mL methylene chloride and dried over sodium sulfate and evaporated. There were obtained 16.7 g of pale beige crystals. The aqueous phase was extracted three times with 100 mL of methylene chloride, the organic phase dried over sodium sulfate and evaporated. 30 g of crystalline product Methyl 4-oxotetrahydrothiophene-3-carboxylate was obtained. Yield: 46.7 g of light beige crystals (81 % of theory). mp 29-31 degC. TLC: Bz:MeOH:AcOH = 45:8:4, Rf = 0.75.
Methyl 4-oxotetrahydrothiophene-3-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
Methyl 4-oxotetrahydrothiophene-3-carboxylate Suppliers
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- Country
- Belgium
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View Lastest Price from Methyl 4-oxotetrahydrothiophene-3-carboxylate manufacturers
- Product
- Methyl 4-oxotetrahydrothiophene-3-carboxylate 2689-68-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-22
- Product
- METHYL 4-OXOTETRAHYDROTHIOPHENE-3-CARBOXYLATE 2689-68-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 85.0-99.8%
- Supply Ability
- 20ton
- Release date
- 2019-12-20